A CF patient with progressive proteinuric renal disease: a CF-specific nodular glomerulosclerosis?

Hdl Handle:
http://hdl.handle.net/10147/203615
Title:
A CF patient with progressive proteinuric renal disease: a CF-specific nodular glomerulosclerosis?
Authors:
O'Connell, O.; Magee, C. N.; Fitzgerald, B.; Burke, L.; Plant, W. D.; Plant, B. J.
Citation:
A CF patient with progressive proteinuric renal disease: a CF-specific nodular glomerulosclerosis? 2010, 3 (4):354 NDT Plus
Journal:
NDT Plus
Issue Date:
2010
URI:
http://hdl.handle.net/10147/203615
DOI:
10.1093/ndtplus/sfq054
Additional Links:
http://ndtplus.oxfordjournals.org/cgi/doi/10.1093/ndtplus/sfq054
Item Type:
Article
Language:
en
Description:
Cystic fibrosis (CF) is a multisystemic disease but without a classical disease-specific renal phenotype. A 32-year-old male patient with CF (ΔF508/ΔF508) presented with a nephrotic syndrome. Renal biopsy revealed nodular glomerulosclerosis (NGS) occurring in the absence of diabetes mellitus, amyloidosis and any other known common cause of NGS. He had a progressive decline in estimated glomerular filtration rate (eGFR) to chronic kidney disease stage V (eGFR <15 mL/min/1.73 m2) over a 3-year period despite optimal medical management. This is the fourth reported case of NGS in a patient with CF without diabetes and is the first to originate from a European country. This case supports the concept of a CF-related NGS.
ISSN:
1753-0784; 1753-0792

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Connell, O.en
dc.contributor.authorMagee, C. N.en
dc.contributor.authorFitzgerald, B.en
dc.contributor.authorBurke, L.en
dc.contributor.authorPlant, W. D.en
dc.contributor.authorPlant, B. J.en
dc.date.accessioned2012-01-18T16:18:38Z-
dc.date.available2012-01-18T16:18:38Z-
dc.date.issued2010-
dc.identifier.citationA CF patient with progressive proteinuric renal disease: a CF-specific nodular glomerulosclerosis? 2010, 3 (4):354 NDT Plusen
dc.identifier.issn1753-0784-
dc.identifier.issn1753-0792-
dc.identifier.doi10.1093/ndtplus/sfq054-
dc.identifier.urihttp://hdl.handle.net/10147/203615-
dc.descriptionCystic fibrosis (CF) is a multisystemic disease but without a classical disease-specific renal phenotype. A 32-year-old male patient with CF (ΔF508/ΔF508) presented with a nephrotic syndrome. Renal biopsy revealed nodular glomerulosclerosis (NGS) occurring in the absence of diabetes mellitus, amyloidosis and any other known common cause of NGS. He had a progressive decline in estimated glomerular filtration rate (eGFR) to chronic kidney disease stage V (eGFR <15 mL/min/1.73 m2) over a 3-year period despite optimal medical management. This is the fourth reported case of NGS in a patient with CF without diabetes and is the first to originate from a European country. This case supports the concept of a CF-related NGS.en
dc.language.isoenen
dc.relation.urlhttp://ndtplus.oxfordjournals.org/cgi/doi/10.1093/ndtplus/sfq054en
dc.titleA CF patient with progressive proteinuric renal disease: a CF-specific nodular glomerulosclerosis?en
dc.typeArticleen
dc.identifier.journalNDT Plusen
dc.description.provinceMunster-
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