Mesenteric venous thrombosis secondary to an unsuspected JAK2 V617F-positive myeloproliferative disorder.
Affiliation
Department of Surgery, Mayo General Hospital, Mayo, Ireland,, mikebourkecork@yahoo.co.uk.Issue Date
2012-01-31T15:55:19Z
Metadata
Show full item recordCitation
Ir J Med Sci. 2009 Aug 20.Journal
Irish journal of medical scienceDOI
10.1007/s11845-009-0331-7PubMed ID
19693645Abstract
BACKGROUND: Mesenteric venous thrombosis (MVT) is a rare but potentially fatal cause of mesenteric ischaemia. It presents insidiously and often diagnosis is made at emergency surgery. In half of the cases MVT develops without a causative factor, while in cases in which a pro-thrombotic state is found to exist MVT may be the first clinically detected consequence of that state. The myeloproliferative disorders (MPD) are known to contribute to the development of pro-thrombotic states. Recently, the JAK2 V617F mutation has been associated with the MPDs. CONCLUSION: We describe a case of MVT occurring secondary to an unsuspected MPD, in which the patient was subsequently found to carry this mutation. We highlight the necessity to screen for this mutation in cases of intra-abdominal thromboses so that appropriate systemic anticoagulation may be instituted, and the patient may be followed so as to detect the development of an overt MPD.Language
ENGISSN
1863-4362 (Electronic)0021-1265 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1007/s11845-009-0331-7
Scopus Count
Collections
Related articles
- The JAK2 V617F mutation frequently occurs in patients with portal and mesenteric venous thrombosis.
- Authors: Colaizzo D, Amitrano L, Tiscia GL, Scenna G, Grandone E, Guardascione MA, Brancaccio V, Margaglione M
- Issue date: 2007 Jan
- Incidence of the JAK2 V617F mutation among patients with splanchnic or cerebral venous thrombosis and without overt chronic myeloproliferative disorders.
- Authors: De Stefano V, Fiorini A, Rossi E, Za T, Farina G, Chiusolo P, Sica S, Leone G
- Issue date: 2007 Apr
- The JAK2 V617F mutation and thrombosis.
- Authors: Austin SK, Lambert JR
- Issue date: 2008 Nov
- Prevalence of JAK29V617F) mutation in intra-abdominal venous thrombosis.
- Authors: Deepak A, Punamiya S, Patel N, Parekh S, Mehta S, Shah N
- Issue date: 2011 Oct-Dec
- JAK2V617F mutation in patients with thrombosis: to screen or not to screen?
- Authors: Xavier SG, Gadelha T, Rezende SM, Zalcberg IR, Spector N
- Issue date: 2011 Apr