Mesenteric venous thrombosis secondary to an unsuspected JAK2 V617F-positive myeloproliferative disorder.

Hdl Handle:
http://hdl.handle.net/10147/203230
Title:
Mesenteric venous thrombosis secondary to an unsuspected JAK2 V617F-positive myeloproliferative disorder.
Affiliation:
Department of Surgery, Mayo General Hospital, Mayo, Ireland,, mikebourkecork@yahoo.co.uk.
Citation:
Ir J Med Sci. 2009 Aug 20.
Journal:
Irish journal of medical science
Issue Date:
31-Jan-2012
URI:
http://hdl.handle.net/10147/203230
DOI:
10.1007/s11845-009-0331-7
PubMed ID:
19693645
Abstract:
BACKGROUND: Mesenteric venous thrombosis (MVT) is a rare but potentially fatal cause of mesenteric ischaemia. It presents insidiously and often diagnosis is made at emergency surgery. In half of the cases MVT develops without a causative factor, while in cases in which a pro-thrombotic state is found to exist MVT may be the first clinically detected consequence of that state. The myeloproliferative disorders (MPD) are known to contribute to the development of pro-thrombotic states. Recently, the JAK2 V617F mutation has been associated with the MPDs. CONCLUSION: We describe a case of MVT occurring secondary to an unsuspected MPD, in which the patient was subsequently found to carry this mutation. We highlight the necessity to screen for this mutation in cases of intra-abdominal thromboses so that appropriate systemic anticoagulation may be instituted, and the patient may be followed so as to detect the development of an overt MPD.
Language:
ENG
ISSN:
1863-4362 (Electronic); 0021-1265 (Linking)

Full metadata record

DC FieldValue Language
dc.date.accessioned2012-01-31T15:55:19Z-
dc.date.available2012-01-31T15:55:19Z-
dc.date.issued2012-01-31T15:55:19Z-
dc.identifier.citationIr J Med Sci. 2009 Aug 20.en_GB
dc.identifier.issn1863-4362 (Electronic)en_GB
dc.identifier.issn0021-1265 (Linking)en_GB
dc.identifier.pmid19693645en_GB
dc.identifier.doi10.1007/s11845-009-0331-7en_GB
dc.identifier.urihttp://hdl.handle.net/10147/203230-
dc.description.abstractBACKGROUND: Mesenteric venous thrombosis (MVT) is a rare but potentially fatal cause of mesenteric ischaemia. It presents insidiously and often diagnosis is made at emergency surgery. In half of the cases MVT develops without a causative factor, while in cases in which a pro-thrombotic state is found to exist MVT may be the first clinically detected consequence of that state. The myeloproliferative disorders (MPD) are known to contribute to the development of pro-thrombotic states. Recently, the JAK2 V617F mutation has been associated with the MPDs. CONCLUSION: We describe a case of MVT occurring secondary to an unsuspected MPD, in which the patient was subsequently found to carry this mutation. We highlight the necessity to screen for this mutation in cases of intra-abdominal thromboses so that appropriate systemic anticoagulation may be instituted, and the patient may be followed so as to detect the development of an overt MPD.en_GB
dc.language.isoENGen_GB
dc.titleMesenteric venous thrombosis secondary to an unsuspected JAK2 V617F-positive myeloproliferative disorder.en_GB
dc.contributor.departmentDepartment of Surgery, Mayo General Hospital, Mayo, Ireland,, mikebourkecork@yahoo.co.uk.en_GB
dc.identifier.journalIrish journal of medical scienceen_GB
dc.description.provinceConnacht-

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