Nitric oxide index is not a predictor of cognitive dysfunction following laparotomy.

Hdl Handle:
http://hdl.handle.net/10147/201313
Title:
Nitric oxide index is not a predictor of cognitive dysfunction following laparotomy.
Authors:
Twomey, Ciaran; Corrigan, Mark; Burlacu, Crina; Butler, Mark; Iohom, Gabriella; Shorten, George
Affiliation:
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital and University College Cork, Ireland. ctwomey@ualberta.ca <ctwomey@ualberta.ca>
Citation:
Nitric oxide index is not a predictor of cognitive dysfunction following laparotomy. 2010, 22 (1):22-8 J Clin Anesth
Journal:
Journal of clinical anesthesia
Issue Date:
Feb-2010
URI:
http://hdl.handle.net/10147/201313
DOI:
10.1016/j.jclinane.2009.02.011
PubMed ID:
20206847
Abstract:
To determine the associations between postoperative cognitive dysfunction (POCD) and plasma concentrations of stable nitric oxide products [nitric oxide index (NOi)].; Prospective study.; Academic hospital.; 28 ASA physical status I, II, and III physical status patients undergoing major non-cardiac surgery.; Cognitive assessment was performed preoperatively and postoperatively at 4 days (early) and 6 weeks (late).; Serial measurements of plasma NOi were recorded.; Early POCD with a deficit in one cognitive domain was present in 18 patients (64%), and in 8 patients (28%) with deficits in two or more cognitive domains. Late POCD was evident in three patients (20%) who had a deficit in one domain. Eight patients were lost to late follow-up. There was no difference in baseline or subsequent serum concentrations of NOi between those who showed early and late POCD and those who showed no POCD.; Factors other than nitric oxide-mediated injury is responsible for POCD following major non-cardiac surgery.
Item Type:
Article
Language:
en
Description:
STUDY OBJECTIVE: To determine the associations between postoperative cognitive dysfunction (POCD) and plasma concentrations of stable nitric oxide products [nitric oxide index (NOi)]. DESIGN: Prospective study. SETTING: Academic hospital. PATIENTS: 28 ASA physical status I, II, and III physical status patients undergoing major non-cardiac surgery. INTERVENTIONS: Cognitive assessment was performed preoperatively and postoperatively at 4 days (early) and 6 weeks (late). MEASUREMENTS: Serial measurements of plasma NOi were recorded. MAIN RESULTS: Early POCD with a deficit in one cognitive domain was present in 18 patients (64%), and in 8 patients (28%) with deficits in two or more cognitive domains. Late POCD was evident in three patients (20%) who had a deficit in one domain. Eight patients were lost to late follow-up. There was no difference in baseline or subsequent serum concentrations of NOi between those who showed early and late POCD and those who showed no POCD. CONCLUSION: Factors other than nitric oxide-mediated injury is responsible for POCD following major non-cardiac surgery.
MeSH:
Biological Markers; Cognition Disorders; Female; Humans; Laparotomy; Male; Middle Aged; Nitric Oxide; Postoperative Complications; Predictive Value of Tests; Prospective Studies
ISSN:
1873-4529

Full metadata record

DC FieldValue Language
dc.contributor.authorTwomey, Ciaranen
dc.contributor.authorCorrigan, Marken
dc.contributor.authorBurlacu, Crinaen
dc.contributor.authorButler, Marken
dc.contributor.authorIohom, Gabriellaen
dc.contributor.authorShorten, Georgeen
dc.date.accessioned2012-01-10T14:55:52Z-
dc.date.available2012-01-10T14:55:52Z-
dc.date.issued2010-02-
dc.identifier.citationNitric oxide index is not a predictor of cognitive dysfunction following laparotomy. 2010, 22 (1):22-8 J Clin Anesthen
dc.identifier.issn1873-4529-
dc.identifier.pmid20206847-
dc.identifier.doi10.1016/j.jclinane.2009.02.011-
dc.identifier.urihttp://hdl.handle.net/10147/201313-
dc.descriptionSTUDY OBJECTIVE: To determine the associations between postoperative cognitive dysfunction (POCD) and plasma concentrations of stable nitric oxide products [nitric oxide index (NOi)]. DESIGN: Prospective study. SETTING: Academic hospital. PATIENTS: 28 ASA physical status I, II, and III physical status patients undergoing major non-cardiac surgery. INTERVENTIONS: Cognitive assessment was performed preoperatively and postoperatively at 4 days (early) and 6 weeks (late). MEASUREMENTS: Serial measurements of plasma NOi were recorded. MAIN RESULTS: Early POCD with a deficit in one cognitive domain was present in 18 patients (64%), and in 8 patients (28%) with deficits in two or more cognitive domains. Late POCD was evident in three patients (20%) who had a deficit in one domain. Eight patients were lost to late follow-up. There was no difference in baseline or subsequent serum concentrations of NOi between those who showed early and late POCD and those who showed no POCD. CONCLUSION: Factors other than nitric oxide-mediated injury is responsible for POCD following major non-cardiac surgery.en
dc.description.abstractTo determine the associations between postoperative cognitive dysfunction (POCD) and plasma concentrations of stable nitric oxide products [nitric oxide index (NOi)].-
dc.description.abstractProspective study.-
dc.description.abstractAcademic hospital.-
dc.description.abstract28 ASA physical status I, II, and III physical status patients undergoing major non-cardiac surgery.-
dc.description.abstractCognitive assessment was performed preoperatively and postoperatively at 4 days (early) and 6 weeks (late).-
dc.description.abstractSerial measurements of plasma NOi were recorded.-
dc.description.abstractEarly POCD with a deficit in one cognitive domain was present in 18 patients (64%), and in 8 patients (28%) with deficits in two or more cognitive domains. Late POCD was evident in three patients (20%) who had a deficit in one domain. Eight patients were lost to late follow-up. There was no difference in baseline or subsequent serum concentrations of NOi between those who showed early and late POCD and those who showed no POCD.-
dc.description.abstractFactors other than nitric oxide-mediated injury is responsible for POCD following major non-cardiac surgery.-
dc.language.isoenen
dc.subject.meshBiological Markers-
dc.subject.meshCognition Disorders-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLaparotomy-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNitric Oxide-
dc.subject.meshPostoperative Complications-
dc.subject.meshPredictive Value of Tests-
dc.subject.meshProspective Studies-
dc.titleNitric oxide index is not a predictor of cognitive dysfunction following laparotomy.en
dc.typeArticleen
dc.contributor.departmentDepartment of Anaesthesia and Intensive Care Medicine, Cork University Hospital and University College Cork, Ireland. ctwomey@ualberta.ca <ctwomey@ualberta.ca>en
dc.identifier.journalJournal of clinical anesthesiaen
dc.description.provinceMunster-

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