Development of low-dose protocols for thin-section CT assessment of cystic fibrosis in pediatric patients.
Authors
O'Connor, Owen JVandeleur, Moya
McGarrigle, Anne Marie
Moore, Niamh
McWilliams, Sebastian R
McSweeney, Sean E
O'Neill, Michael
Ni Chroinin, Muireann
Maher, Michael M
Affiliation
Department of Radiology, University College Cork and Cork University Hospital, Wilton, Cork 1111, Ireland.Issue Date
2010-12MeSH
AdolescentChild
Child, Preschool
Cystic Fibrosis
Female
Humans
Male
Prospective Studies
Radiation Dosage
Radiography, Thoracic
Statistics, Nonparametric
Tomography, X-Ray Computed
Young Adult
Metadata
Show full item recordCitation
Development of low-dose protocols for thin-section CT assessment of cystic fibrosis in pediatric patients. 2010, 257 (3):820-9 RadiologyJournal
RadiologyDOI
10.1148/radiol.10100278PubMed ID
20876388Additional Links
http://radiology.rsna.org/content/257/3/820.full.pdf+htmlAbstract
To develop low-dose thin-section computed tomographic (CT) protocols for assessment of cystic fibrosis (CF) in pediatric patients and determine the clinical usefulness thereof compared with chest radiography.After institutional review board approval and informed consent from patients or guardians were obtained, 14 patients with CF and 11 patients without CF (16 male, nine female; mean age, 12.6 years ± 5.4 [standard deviation]; range, 3.5-25 years) who underwent imaging for clinical reasons underwent low-dose thin-section CT. Sections 1 mm thick (protocol A) were used in 10 patients, and sections 0.5 mm thick (protocol B) were used in 15 patients at six levels at 120 kVp and 30-50 mA. Image quality and diagnostic acceptability were scored qualitatively and quantitatively by two radiologists who also quantified disease severity at thin-section CT and chest radiography. Effective doses were calculated by using a CT dosimetry calculator.
Low-dose thin-section CT was performed with mean effective doses of 0.19 mSv ± 0.03 for protocol A and 0.14 mSv ± 0.04 for protocol B (P < .005). Diagnostic acceptability and depiction of bronchovascular structures at lung window settings were graded as almost excellent for both protocols, but protocol B was inferior to protocol A for mediastinal assessment (P < .02). Patients with CF had moderate lung disease with a mean Bhalla score of 9.2 ± 5.3 (range, 0-19), compared with that of patients without CF (1.1 ± 1.4; P < .001). There was excellent correlation between thin-section CT and chest radiography (r = 0.88-0.92; P < .001).
Low-dose thin-section CT can be performed at lower effective doses than can standard CT, approaching those of chest radiography. Low-dose thin-section CT could be appropriate for evaluating bronchiectasis in pediatric patients, yielding appropriate information about lung parenchyma and bronchovascular structures.
Item Type
ArticleLanguage
enISSN
1527-1315ae974a485f413a2113503eed53cd6c53
10.1148/radiol.10100278