Hdl Handle:
http://hdl.handle.net/10147/201291
Title:
Inflammatory markers in depression.
Authors:
Dinan, Timothy G
Affiliation:
Department of Psychiatry and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. t.dinan@ucc.ie
Citation:
Inflammatory markers in depression. 2009, 22 (1):32-6 Curr Opin Psychiatry
Journal:
Current opinion in psychiatry
Issue Date:
Jan-2009
URI:
http://hdl.handle.net/10147/201291
DOI:
10.1097/YCO.0b013e328315a561
PubMed ID:
19122532
Abstract:
To provide a critical update of the literature linking depression and inflammation, together with possible underlying mechanisms and longer term risk of cardiovascular disease.; The current literature lends further support to the view that major depression is associated with a proinflammatory response, as indexed by elevation in C-reactive protein and cytokines such as interleukin 6 and tumour necrosis factor-alpha. Antidepressants suppress the inflammatory response, whereas electroconvulsive therapy acutely increases proinflammatory cytokine levels. Most, though not all, studies support a link between depression, inflammation and cardiovascular events.; Depression is an inflammatory state that may increase the risk of cardiac disease. Whether or not the immune system is an appropriate target for antidepressant development has yet to be established.
Item Type:
Article
Language:
en
Description:
PURPOSE OF REVIEW: To provide a critical update of the literature linking depression and inflammation, together with possible underlying mechanisms and longer term risk of cardiovascular disease. RECENT FINDINGS: The current literature lends further support to the view that major depression is associated with a proinflammatory response, as indexed by elevation in C-reactive protein and cytokines such as interleukin 6 and tumour necrosis factor-alpha. Antidepressants suppress the inflammatory response, whereas electroconvulsive therapy acutely increases proinflammatory cytokine levels. Most, though not all, studies support a link between depression, inflammation and cardiovascular events. SUMMARY: Depression is an inflammatory state that may increase the risk of cardiac disease. Whether or not the immune system is an appropriate target for antidepressant development has yet to be established.
MeSH:
Acute-Phase Proteins; Biological Markers; C-Reactive Protein; Coronary Disease; Cytokines; Depressive Disorder, Major; Humans; Inflammation; Serotonin
ISSN:
1473-6578

Full metadata record

DC FieldValue Language
dc.contributor.authorDinan, Timothy Gen
dc.date.accessioned2012-01-10T13:04:45Z-
dc.date.available2012-01-10T13:04:45Z-
dc.date.issued2009-01-
dc.identifier.citationInflammatory markers in depression. 2009, 22 (1):32-6 Curr Opin Psychiatryen
dc.identifier.issn1473-6578-
dc.identifier.pmid19122532-
dc.identifier.doi10.1097/YCO.0b013e328315a561-
dc.identifier.urihttp://hdl.handle.net/10147/201291-
dc.descriptionPURPOSE OF REVIEW: To provide a critical update of the literature linking depression and inflammation, together with possible underlying mechanisms and longer term risk of cardiovascular disease. RECENT FINDINGS: The current literature lends further support to the view that major depression is associated with a proinflammatory response, as indexed by elevation in C-reactive protein and cytokines such as interleukin 6 and tumour necrosis factor-alpha. Antidepressants suppress the inflammatory response, whereas electroconvulsive therapy acutely increases proinflammatory cytokine levels. Most, though not all, studies support a link between depression, inflammation and cardiovascular events. SUMMARY: Depression is an inflammatory state that may increase the risk of cardiac disease. Whether or not the immune system is an appropriate target for antidepressant development has yet to be established.en
dc.description.abstractTo provide a critical update of the literature linking depression and inflammation, together with possible underlying mechanisms and longer term risk of cardiovascular disease.-
dc.description.abstractThe current literature lends further support to the view that major depression is associated with a proinflammatory response, as indexed by elevation in C-reactive protein and cytokines such as interleukin 6 and tumour necrosis factor-alpha. Antidepressants suppress the inflammatory response, whereas electroconvulsive therapy acutely increases proinflammatory cytokine levels. Most, though not all, studies support a link between depression, inflammation and cardiovascular events.-
dc.description.abstractDepression is an inflammatory state that may increase the risk of cardiac disease. Whether or not the immune system is an appropriate target for antidepressant development has yet to be established.-
dc.language.isoenen
dc.subject.meshAcute-Phase Proteins-
dc.subject.meshBiological Markers-
dc.subject.meshC-Reactive Protein-
dc.subject.meshCoronary Disease-
dc.subject.meshCytokines-
dc.subject.meshDepressive Disorder, Major-
dc.subject.meshHumans-
dc.subject.meshInflammation-
dc.subject.meshSerotonin-
dc.titleInflammatory markers in depression.en
dc.typeArticleen
dc.contributor.departmentDepartment of Psychiatry and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. t.dinan@ucc.ieen
dc.identifier.journalCurrent opinion in psychiatryen
dc.description.provinceMunster-

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