Are elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly.

Hdl Handle:
http://hdl.handle.net/10147/201250
Title:
Are elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly.
Authors:
Sattar, N; Murray, H M; Welsh, P; Blauw, G J; Buckley, B M; de Craen, A J; Ford, I; Forouhi, N G; Freeman, D J; Jukema, J W; Macfarlane, P W; Murphy, M B; Packard, C J; Stott, D J; Westendorp, R G J; Shepherd, J
Affiliation:
Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, University Place, Glasgow G12 8TA, UK. nsattar@clinmed.gla.ac.uk
Citation:
Are elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly. 2009, 52 (2):235-9 Diabetologia
Journal:
Diabetologia
Issue Date:
Feb-2009
URI:
http://hdl.handle.net/10147/201250
DOI:
10.1007/s00125-008-1217-3
PubMed ID:
19030842
Abstract:
The aim of this prospective study was to determine whether circulating intercellular adhesion molecule (ICAM) 1, as a potential surrogate of 'endothelial activation', is more strongly associated with risk of vascular events than with incident diabetes.; We related baseline ICAM-1 levels to vascular events (866 CHD and stroke events in 5,685 participants) and incident diabetes (292 in 4,945 without baseline diabetes) in the elderly over 3.2 years of follow-up.; ICAM-1 levels correlated positively with triacylglycerol but negatively with LDL- and HDL-cholesterol. ICAM-1 levels were higher in those who developed diabetes (388.6 +/- 1.42 vs 369.4 +/- 1.39 ng/ml [mean+/-SD], p = 0.011) and remained independently associated with new-onset diabetes (HR 1.84, 95% CI 1.26-2.69, p = 0.0015 per unit increase in log[ICAM-1] after adjusting for classical risk factors and C-reactive protein). By contrast, ICAM-1 levels were not significantly (p = 0.40) elevated in those who had an incident vascular event compared with those who remained event-free, and corresponding adjusted risk associations were null (HR 0.98, 95% CI 0.80-1.22, p = 0.89) in analyses adjusted for other risk factors.; We show that elevated ICAM-1 levels are associated with risk of incident diabetes in the elderly at risk, despite no association with incident cardiovascular disease risk. We suggest that perturbations in circulating ICAM-1 levels are aligned more towards diabetes risk.
Item Type:
Article
Language:
en
Description:
AIMS/HYPOTHESIS: The aim of this prospective study was to determine whether circulating intercellular adhesion molecule (ICAM) 1, as a potential surrogate of 'endothelial activation', is more strongly associated with risk of vascular events than with incident diabetes. METHODS: We related baseline ICAM-1 levels to vascular events (866 CHD and stroke events in 5,685 participants) and incident diabetes (292 in 4,945 without baseline diabetes) in the elderly over 3.2 years of follow-up. RESULTS: ICAM-1 levels correlated positively with triacylglycerol but negatively with LDL- and HDL-cholesterol. ICAM-1 levels were higher in those who developed diabetes (388.6 +/- 1.42 vs 369.4 +/- 1.39 ng/ml [mean+/-SD], p = 0.011) and remained independently associated with new-onset diabetes (HR 1.84, 95% CI 1.26-2.69, p = 0.0015 per unit increase in log[ICAM-1] after adjusting for classical risk factors and C-reactive protein). By contrast, ICAM-1 levels were not significantly (p = 0.40) elevated in those who had an incident vascular event compared with those who remained event-free, and corresponding adjusted risk associations were null (HR 0.98, 95% CI 0.80-1.22, p = 0.89) in analyses adjusted for other risk factors. CONCLUSIONS/INTERPRETATION: We show that elevated ICAM-1 levels are associated with risk of incident diabetes in the elderly at risk, despite no association with incident cardiovascular disease risk. We suggest that perturbations in circulating ICAM-1 levels are aligned more towards diabetes risk.
MeSH:
Aged; Aged, 80 and over; Blood Pressure; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Intercellular Adhesion Molecule-1; Male; Myocardial Infarction; Pravastatin; Predictive Value of Tests; Prospective Studies; Risk Factors; Stroke; Time Factors
ISSN:
1432-0428

Full metadata record

DC FieldValue Language
dc.contributor.authorSattar, Nen
dc.contributor.authorMurray, H Men
dc.contributor.authorWelsh, Pen
dc.contributor.authorBlauw, G Jen
dc.contributor.authorBuckley, B Men
dc.contributor.authorde Craen, A Jen
dc.contributor.authorFord, Ien
dc.contributor.authorForouhi, N Gen
dc.contributor.authorFreeman, D Jen
dc.contributor.authorJukema, J Wen
dc.contributor.authorMacfarlane, P Wen
dc.contributor.authorMurphy, M Ben
dc.contributor.authorPackard, C Jen
dc.contributor.authorStott, D Jen
dc.contributor.authorWestendorp, R G Jen
dc.contributor.authorShepherd, Jen
dc.date.accessioned2012-01-10T12:53:08Z-
dc.date.available2012-01-10T12:53:08Z-
dc.date.issued2009-02-
dc.identifier.citationAre elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly. 2009, 52 (2):235-9 Diabetologiaen
dc.identifier.issn1432-0428-
dc.identifier.pmid19030842-
dc.identifier.doi10.1007/s00125-008-1217-3-
dc.identifier.urihttp://hdl.handle.net/10147/201250-
dc.descriptionAIMS/HYPOTHESIS: The aim of this prospective study was to determine whether circulating intercellular adhesion molecule (ICAM) 1, as a potential surrogate of 'endothelial activation', is more strongly associated with risk of vascular events than with incident diabetes. METHODS: We related baseline ICAM-1 levels to vascular events (866 CHD and stroke events in 5,685 participants) and incident diabetes (292 in 4,945 without baseline diabetes) in the elderly over 3.2 years of follow-up. RESULTS: ICAM-1 levels correlated positively with triacylglycerol but negatively with LDL- and HDL-cholesterol. ICAM-1 levels were higher in those who developed diabetes (388.6 +/- 1.42 vs 369.4 +/- 1.39 ng/ml [mean+/-SD], p = 0.011) and remained independently associated with new-onset diabetes (HR 1.84, 95% CI 1.26-2.69, p = 0.0015 per unit increase in log[ICAM-1] after adjusting for classical risk factors and C-reactive protein). By contrast, ICAM-1 levels were not significantly (p = 0.40) elevated in those who had an incident vascular event compared with those who remained event-free, and corresponding adjusted risk associations were null (HR 0.98, 95% CI 0.80-1.22, p = 0.89) in analyses adjusted for other risk factors. CONCLUSIONS/INTERPRETATION: We show that elevated ICAM-1 levels are associated with risk of incident diabetes in the elderly at risk, despite no association with incident cardiovascular disease risk. We suggest that perturbations in circulating ICAM-1 levels are aligned more towards diabetes risk.en
dc.description.abstractThe aim of this prospective study was to determine whether circulating intercellular adhesion molecule (ICAM) 1, as a potential surrogate of 'endothelial activation', is more strongly associated with risk of vascular events than with incident diabetes.-
dc.description.abstractWe related baseline ICAM-1 levels to vascular events (866 CHD and stroke events in 5,685 participants) and incident diabetes (292 in 4,945 without baseline diabetes) in the elderly over 3.2 years of follow-up.-
dc.description.abstractICAM-1 levels correlated positively with triacylglycerol but negatively with LDL- and HDL-cholesterol. ICAM-1 levels were higher in those who developed diabetes (388.6 +/- 1.42 vs 369.4 +/- 1.39 ng/ml [mean+/-SD], p = 0.011) and remained independently associated with new-onset diabetes (HR 1.84, 95% CI 1.26-2.69, p = 0.0015 per unit increase in log[ICAM-1] after adjusting for classical risk factors and C-reactive protein). By contrast, ICAM-1 levels were not significantly (p = 0.40) elevated in those who had an incident vascular event compared with those who remained event-free, and corresponding adjusted risk associations were null (HR 0.98, 95% CI 0.80-1.22, p = 0.89) in analyses adjusted for other risk factors.-
dc.description.abstractWe show that elevated ICAM-1 levels are associated with risk of incident diabetes in the elderly at risk, despite no association with incident cardiovascular disease risk. We suggest that perturbations in circulating ICAM-1 levels are aligned more towards diabetes risk.-
dc.language.isoenen
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshBlood Pressure-
dc.subject.meshCholesterol-
dc.subject.meshCholesterol, HDL-
dc.subject.meshCholesterol, LDL-
dc.subject.meshDiabetes Mellitus-
dc.subject.meshEndothelium, Vascular-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHumans-
dc.subject.meshHydroxymethylglutaryl-CoA Reductase Inhibitors-
dc.subject.meshIncidence-
dc.subject.meshIntercellular Adhesion Molecule-1-
dc.subject.meshMale-
dc.subject.meshMyocardial Infarction-
dc.subject.meshPravastatin-
dc.subject.meshPredictive Value of Tests-
dc.subject.meshProspective Studies-
dc.subject.meshRisk Factors-
dc.subject.meshStroke-
dc.subject.meshTime Factors-
dc.titleAre elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly.en
dc.typeArticleen
dc.contributor.departmentFaculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, University Place, Glasgow G12 8TA, UK. nsattar@clinmed.gla.ac.uken
dc.identifier.journalDiabetologiaen
dc.description.provinceMunster-

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.