BCG protects toddlers during a tuberculosis outbreak.

Hdl Handle:
http://hdl.handle.net/10147/201211
Title:
BCG protects toddlers during a tuberculosis outbreak.
Authors:
Gaensbauer, J T; Vandaleur, M; O'Neil, M; Altaf, A; Ní Chróinín, M
Affiliation:
Division of Paediatrics, Cork University Hospital, Wilton Road, Wilton, Cork, Ireland. jgaens@u.washington.edu
Citation:
BCG protects toddlers during a tuberculosis outbreak. 2009, 94 (5):392-3 Arch. Dis. Child.
Journal:
Archives of disease in childhood
Issue Date:
May-2009
URI:
http://hdl.handle.net/10147/201211
DOI:
10.1136/adc.2008.145755
PubMed ID:
19190006
Abstract:
In 2007, an outbreak of tuberculosis occurred in a toddler population attending two child care centres in Cork, Ireland. Of 268 children exposed, 18 were eventually diagnosed with active tuberculosis. We present the initial clinical and radiographic characteristics of the active disease group. Mantoux testing was positive in only 66% of cases. All cases were either pulmonary or involved hilar adenopathy on chest radiograph; there were no cases of disseminated disease or meningitis. 24% of the exposed children had been previously vaccinated with BCG, and no case of active disease was found in this group (p = 0.016), suggesting a profound protective effect of BCG in this population. Our experience provides evidence supporting a protective effect of BCG against pulmonary disease in young children.
Item Type:
Article
Language:
en
Description:
In 2007, an outbreak of tuberculosis occurred in a toddler population attending two child care centres in Cork, Ireland. Of 268 children exposed, 18 were eventually diagnosed with active tuberculosis. We present the initial clinical and radiographic characteristics of the active disease group. Mantoux testing was positive in only 66% of cases. All cases were either pulmonary or involved hilar adenopathy on chest radiograph; there were no cases of disseminated disease or meningitis. 24% of the exposed children had been previously vaccinated with BCG, and no case of active disease was found in this group (p = 0.016), suggesting a profound protective effect of BCG in this population. Our experience provides evidence supporting a protective effect of BCG against pulmonary disease in young children.
MeSH:
Adjuvants, Immunologic; BCG Vaccine; Child, Preschool; Disease Outbreaks; Female; Humans; Immunization Programs; Ireland; Male; Tuberculosis, Pulmonary
ISSN:
1468-2044

Full metadata record

DC FieldValue Language
dc.contributor.authorGaensbauer, J Ten
dc.contributor.authorVandaleur, Men
dc.contributor.authorO'Neil, Men
dc.contributor.authorAltaf, Aen
dc.contributor.authorNí Chróinín, Men
dc.date.accessioned2012-01-10T11:46:09Z-
dc.date.available2012-01-10T11:46:09Z-
dc.date.issued2009-05-
dc.identifier.citationBCG protects toddlers during a tuberculosis outbreak. 2009, 94 (5):392-3 Arch. Dis. Child.en
dc.identifier.issn1468-2044-
dc.identifier.pmid19190006-
dc.identifier.doi10.1136/adc.2008.145755-
dc.identifier.urihttp://hdl.handle.net/10147/201211-
dc.descriptionIn 2007, an outbreak of tuberculosis occurred in a toddler population attending two child care centres in Cork, Ireland. Of 268 children exposed, 18 were eventually diagnosed with active tuberculosis. We present the initial clinical and radiographic characteristics of the active disease group. Mantoux testing was positive in only 66% of cases. All cases were either pulmonary or involved hilar adenopathy on chest radiograph; there were no cases of disseminated disease or meningitis. 24% of the exposed children had been previously vaccinated with BCG, and no case of active disease was found in this group (p = 0.016), suggesting a profound protective effect of BCG in this population. Our experience provides evidence supporting a protective effect of BCG against pulmonary disease in young children.en
dc.description.abstractIn 2007, an outbreak of tuberculosis occurred in a toddler population attending two child care centres in Cork, Ireland. Of 268 children exposed, 18 were eventually diagnosed with active tuberculosis. We present the initial clinical and radiographic characteristics of the active disease group. Mantoux testing was positive in only 66% of cases. All cases were either pulmonary or involved hilar adenopathy on chest radiograph; there were no cases of disseminated disease or meningitis. 24% of the exposed children had been previously vaccinated with BCG, and no case of active disease was found in this group (p = 0.016), suggesting a profound protective effect of BCG in this population. Our experience provides evidence supporting a protective effect of BCG against pulmonary disease in young children.-
dc.language.isoenen
dc.subject.meshAdjuvants, Immunologic-
dc.subject.meshBCG Vaccine-
dc.subject.meshChild, Preschool-
dc.subject.meshDisease Outbreaks-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunization Programs-
dc.subject.meshIreland-
dc.subject.meshMale-
dc.subject.meshTuberculosis, Pulmonary-
dc.titleBCG protects toddlers during a tuberculosis outbreak.en
dc.typeArticleen
dc.contributor.departmentDivision of Paediatrics, Cork University Hospital, Wilton Road, Wilton, Cork, Ireland. jgaens@u.washington.eduen
dc.identifier.journalArchives of disease in childhooden
dc.description.provinceMunster-

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