Can mean platelet component be used as an index of platelet activity in stable coronary artery disease?

Hdl Handle:
http://hdl.handle.net/10147/201000
Title:
Can mean platelet component be used as an index of platelet activity in stable coronary artery disease?
Authors:
Cooke, John; Murphy, Tracy; McFadden, Eugene; O'Reilly, Mairead; Cahill, Mary R
Affiliation:
Mid-Western Regional Hospital, Dooradoyle, Limerick, Ireland.
Citation:
Can mean platelet component be used as an index of platelet activity in stable coronary artery disease? 2009, 14 (2):111-4 Hematology
Journal:
Hematology (Amsterdam, Netherlands)
Issue Date:
Apr-2009
URI:
http://hdl.handle.net/10147/201000
DOI:
10.1179/102453309X385160
PubMed ID:
19298724
Abstract:
Acute coronary syndrome is associated with intracoronary thrombosis secondary to platelet activation. Previous groups have investigated platelet activation in both stable and unstable vascular disease. Most measures of platelet activation are not routinely available or easily adaptable to large scale clinical use. Recently, measurement of the mean platelet component (MPC) has become part of the routine data provided by an automated full blood count analyser, the Advia 120. MPC measures platelet density which changes on platelet activation. Our objectives were to determine if platelet activation, as measured by MPC, is increased in patients with stable coronary artery disease (CAD) and to determine if MPC could be useful in differentiating people with stable CAD from controls on an everyday clinical basis. Three hundred and forty-five consecutive patients attending for elective coronary angiography had full blood count analysis and MPC measurement performed using an ADVIA-120 analyser. Three hundred and twenty-four were analysed in our final dataset. Two hundred and fifty-three (78%) had CAD. Patients with CAD were significantly (p<0.001) older than those without (63.8 versus 56.0 years). Results failed to demonstrate a difference (p=0.467) in MPC between patients with CAD and those with normal coronary arteries (25.8 versus 26.0). Likewise, there was no correlation between MPC and the severity of CAD (Kendall's tau b=-0.086, p=0.04). MPC is not a useful index of platelet activity in stable CAD when used in everyday clinical practice.
Item Type:
Article
Language:
en
Description:
Acute coronary syndrome is associated with intracoronary thrombosis secondary to platelet activation. Previous groups have investigated platelet activation in both stable and unstable vascular disease. Most measures of platelet activation are not routinely available or easily adaptable to large scale clinical use. Recently, measurement of the mean platelet component (MPC) has become part of the routine data provided by an automated full blood count analyser, the Advia 120. MPC measures platelet density which changes on platelet activation. Our objectives were to determine if platelet activation, as measured by MPC, is increased in patients with stable coronary artery disease (CAD) and to determine if MPC could be useful in differentiating people with stable CAD from controls on an everyday clinical basis. Three hundred and forty-five consecutive patients attending for elective coronary angiography had full blood count analysis and MPC measurement performed using an ADVIA-120 analyser. Three hundred and twenty-four were analysed in our final dataset. Two hundred and fifty-three (78%) had CAD. Patients with CAD were significantly (p<0.001) older than those without (63.8 versus 56.0 years). Results failed to demonstrate a difference (p=0.467) in MPC between patients with CAD and those with normal coronary arteries (25.8 versus 26.0). Likewise, there was no correlation between MPC and the severity of CAD (Kendall's tau b=-0.086, p=0.04). MPC is not a useful index of platelet activity in stable CAD when used in everyday clinical practice.
MeSH:
Blood Platelets; Case-Control Studies; Coronary Angiography; Coronary Artery Disease; Female; Flow Cytometry; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Count; Prospective Studies
ISSN:
1607-8454

Full metadata record

DC FieldValue Language
dc.contributor.authorCooke, Johnen
dc.contributor.authorMurphy, Tracyen
dc.contributor.authorMcFadden, Eugeneen
dc.contributor.authorO'Reilly, Maireaden
dc.contributor.authorCahill, Mary Ren
dc.date.accessioned2012-01-09T16:49:44Z-
dc.date.available2012-01-09T16:49:44Z-
dc.date.issued2009-04-
dc.identifier.citationCan mean platelet component be used as an index of platelet activity in stable coronary artery disease? 2009, 14 (2):111-4 Hematologyen
dc.identifier.issn1607-8454-
dc.identifier.pmid19298724-
dc.identifier.doi10.1179/102453309X385160-
dc.identifier.urihttp://hdl.handle.net/10147/201000-
dc.descriptionAcute coronary syndrome is associated with intracoronary thrombosis secondary to platelet activation. Previous groups have investigated platelet activation in both stable and unstable vascular disease. Most measures of platelet activation are not routinely available or easily adaptable to large scale clinical use. Recently, measurement of the mean platelet component (MPC) has become part of the routine data provided by an automated full blood count analyser, the Advia 120. MPC measures platelet density which changes on platelet activation. Our objectives were to determine if platelet activation, as measured by MPC, is increased in patients with stable coronary artery disease (CAD) and to determine if MPC could be useful in differentiating people with stable CAD from controls on an everyday clinical basis. Three hundred and forty-five consecutive patients attending for elective coronary angiography had full blood count analysis and MPC measurement performed using an ADVIA-120 analyser. Three hundred and twenty-four were analysed in our final dataset. Two hundred and fifty-three (78%) had CAD. Patients with CAD were significantly (p<0.001) older than those without (63.8 versus 56.0 years). Results failed to demonstrate a difference (p=0.467) in MPC between patients with CAD and those with normal coronary arteries (25.8 versus 26.0). Likewise, there was no correlation between MPC and the severity of CAD (Kendall's tau b=-0.086, p=0.04). MPC is not a useful index of platelet activity in stable CAD when used in everyday clinical practice.en
dc.description.abstractAcute coronary syndrome is associated with intracoronary thrombosis secondary to platelet activation. Previous groups have investigated platelet activation in both stable and unstable vascular disease. Most measures of platelet activation are not routinely available or easily adaptable to large scale clinical use. Recently, measurement of the mean platelet component (MPC) has become part of the routine data provided by an automated full blood count analyser, the Advia 120. MPC measures platelet density which changes on platelet activation. Our objectives were to determine if platelet activation, as measured by MPC, is increased in patients with stable coronary artery disease (CAD) and to determine if MPC could be useful in differentiating people with stable CAD from controls on an everyday clinical basis. Three hundred and forty-five consecutive patients attending for elective coronary angiography had full blood count analysis and MPC measurement performed using an ADVIA-120 analyser. Three hundred and twenty-four were analysed in our final dataset. Two hundred and fifty-three (78%) had CAD. Patients with CAD were significantly (p<0.001) older than those without (63.8 versus 56.0 years). Results failed to demonstrate a difference (p=0.467) in MPC between patients with CAD and those with normal coronary arteries (25.8 versus 26.0). Likewise, there was no correlation between MPC and the severity of CAD (Kendall's tau b=-0.086, p=0.04). MPC is not a useful index of platelet activity in stable CAD when used in everyday clinical practice.-
dc.language.isoenen
dc.subject.meshBlood Platelets-
dc.subject.meshCase-Control Studies-
dc.subject.meshCoronary Angiography-
dc.subject.meshCoronary Artery Disease-
dc.subject.meshFemale-
dc.subject.meshFlow Cytometry-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshP-Selectin-
dc.subject.meshPlatelet Activation-
dc.subject.meshPlatelet Count-
dc.subject.meshProspective Studies-
dc.titleCan mean platelet component be used as an index of platelet activity in stable coronary artery disease?en
dc.typeArticleen
dc.contributor.departmentMid-Western Regional Hospital, Dooradoyle, Limerick, Ireland.en
dc.identifier.journalHematology (Amsterdam, Netherlands)en
dc.description.provinceMunster-

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