Association of collagen type I alpha1 (COLIA1) Sp1 polymorphism with osteoporotic fracture in Caucasian post-menopausal women: a meta-analysis.

Hdl Handle:
http://hdl.handle.net/10147/200772
Title:
Association of collagen type I alpha1 (COLIA1) Sp1 polymorphism with osteoporotic fracture in Caucasian post-menopausal women: a meta-analysis.
Authors:
Ji, G-R; Yao, M; Sun, C-Y; Zhang, L; Han, Z
Affiliation:
Department of Orthopaedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China. guangrongji2009@hotmail.com
Citation:
Association of collagen type I alpha1 (COLIA1) Sp1 polymorphism with osteoporotic fracture in Caucasian post-menopausal women: a meta-analysis., 37 (6):1725-32 J. Int. Med. Res.
Journal:
The Journal of international medical research
Issue Date:
6-Jan-2012
URI:
http://hdl.handle.net/10147/200772
PubMed ID:
20146870
Abstract:
This study was designed to summarize quantitatively the evidence for a relationship between collagen type I alpha1 (COLIA1) Sp1 polymorphism and osteoporotic fracture risk in Caucasian post-menopausal women. This meta-analysis included 16 studies, which analysed 2294 patients with fractures and 10 285 controls. The combined results showed that there was a significant difference in genotype distribution (SS odds ratio [OR] 0.72; Ss OR 1.18; ss OR 1.97) between patients with fractures and controls. When stratifying by the fracture site, it was found that: (i) patients with vertebral fractures had a significantly higher frequency of the Ss genotype and a lower frequency of the SS genotype than controls; and (ii) patients with non-vertebral fractures had a significantly higher frequency of the ss genotype and a lower frequency of the SS genotype than controls. This meta-analysis suggests that the COLIA1 Sp1 polymorphism may be associated with osteoporotic fracture in Caucasian post-menopausal women.
Item Type:
Article
Language:
en
Description:
This study was designed to summarize quantitatively the evidence for a relationship between collagen type I alpha1 (COLIA1) Sp1 polymorphism and osteoporotic fracture risk in Caucasian post-menopausal women. This meta-analysis included 16 studies, which analysed 2294 patients with fractures and 10 285 controls. The combined results showed that there was a significant difference in genotype distribution (SS odds ratio [OR] 0.72; Ss OR 1.18; ss OR 1.97) between patients with fractures and controls. When stratifying by the fracture site, it was found that: (i) patients with vertebral fractures had a significantly higher frequency of the Ss genotype and a lower frequency of the SS genotype than controls; and (ii) patients with non-vertebral fractures had a significantly higher frequency of the ss genotype and a lower frequency of the SS genotype than controls. This meta-analysis suggests that the COLIA1 Sp1 polymorphism may be associated with osteoporotic fracture in Caucasian post-menopausal women.
MeSH:
Aged; Aged, 80 and over; Binding Sites; Collagen Type I; European Continental Ancestry Group; Female; Fractures, Bone; Genetic Predisposition to Disease; Humans; Middle Aged; Osteoporosis; Polymorphism, Genetic; Postmenopause; Sp1 Transcription Factor
ISSN:
0300-0605

Full metadata record

DC FieldValue Language
dc.contributor.authorJi, G-Ren
dc.contributor.authorYao, Men
dc.contributor.authorSun, C-Yen
dc.contributor.authorZhang, Len
dc.contributor.authorHan, Zen
dc.date.accessioned2012-01-06T15:44:39Z-
dc.date.available2012-01-06T15:44:39Z-
dc.date.issued2012-01-06T15:44:39Z-
dc.identifier.citationAssociation of collagen type I alpha1 (COLIA1) Sp1 polymorphism with osteoporotic fracture in Caucasian post-menopausal women: a meta-analysis., 37 (6):1725-32 J. Int. Med. Res.en
dc.identifier.issn0300-0605-
dc.identifier.pmid20146870-
dc.identifier.urihttp://hdl.handle.net/10147/200772-
dc.descriptionThis study was designed to summarize quantitatively the evidence for a relationship between collagen type I alpha1 (COLIA1) Sp1 polymorphism and osteoporotic fracture risk in Caucasian post-menopausal women. This meta-analysis included 16 studies, which analysed 2294 patients with fractures and 10 285 controls. The combined results showed that there was a significant difference in genotype distribution (SS odds ratio [OR] 0.72; Ss OR 1.18; ss OR 1.97) between patients with fractures and controls. When stratifying by the fracture site, it was found that: (i) patients with vertebral fractures had a significantly higher frequency of the Ss genotype and a lower frequency of the SS genotype than controls; and (ii) patients with non-vertebral fractures had a significantly higher frequency of the ss genotype and a lower frequency of the SS genotype than controls. This meta-analysis suggests that the COLIA1 Sp1 polymorphism may be associated with osteoporotic fracture in Caucasian post-menopausal women.en
dc.description.abstractThis study was designed to summarize quantitatively the evidence for a relationship between collagen type I alpha1 (COLIA1) Sp1 polymorphism and osteoporotic fracture risk in Caucasian post-menopausal women. This meta-analysis included 16 studies, which analysed 2294 patients with fractures and 10 285 controls. The combined results showed that there was a significant difference in genotype distribution (SS odds ratio [OR] 0.72; Ss OR 1.18; ss OR 1.97) between patients with fractures and controls. When stratifying by the fracture site, it was found that: (i) patients with vertebral fractures had a significantly higher frequency of the Ss genotype and a lower frequency of the SS genotype than controls; and (ii) patients with non-vertebral fractures had a significantly higher frequency of the ss genotype and a lower frequency of the SS genotype than controls. This meta-analysis suggests that the COLIA1 Sp1 polymorphism may be associated with osteoporotic fracture in Caucasian post-menopausal women.-
dc.language.isoenen
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshBinding Sites-
dc.subject.meshCollagen Type I-
dc.subject.meshEuropean Continental Ancestry Group-
dc.subject.meshFemale-
dc.subject.meshFractures, Bone-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshHumans-
dc.subject.meshMiddle Aged-
dc.subject.meshOsteoporosis-
dc.subject.meshPolymorphism, Genetic-
dc.subject.meshPostmenopause-
dc.subject.meshSp1 Transcription Factor-
dc.titleAssociation of collagen type I alpha1 (COLIA1) Sp1 polymorphism with osteoporotic fracture in Caucasian post-menopausal women: a meta-analysis.en
dc.typeArticleen
dc.contributor.departmentDepartment of Orthopaedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China. guangrongji2009@hotmail.comen
dc.identifier.journalThe Journal of international medical researchen
dc.description.provinceMunster-

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