Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials.

Hdl Handle:
http://hdl.handle.net/10147/200331
Title:
Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials.
Authors:
Sattar, Naveed; Preiss, David; Murray, Heather M; Welsh, Paul; Buckley, Brendan M; de Craen, Anton J M; Seshasai, Sreenivasa Rao Kondapally; McMurray, John J; Freeman, Dilys J; Jukema, J Wouter; Macfarlane, Peter W; Packard, Chris J; Stott, David J; Westendorp, Rudi G; Shepherd, James; Davis, Barry R; Pressel, Sara L; Marchioli, Roberto; Marfisi, Rosa Maria; Maggioni, Aldo P; Tavazzi, Luigi; Tognoni, Gianni; Kjekshus, John; Pedersen, Terje R; Cook, Thomas J; Gotto, Antonio M; Clearfield, Michael B; Downs, John R; Nakamura, Haruo; Ohashi, Yasuo; Mizuno, Kyoichi; Ray, Kausik K; Ford, Ian
Affiliation:
British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. nsattar@clinmed.gla.ac.uk
Citation:
Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. 2010, 375 (9716):735-42 Lancet
Publisher:
Elsevier
Journal:
Lancet
Issue Date:
27-Feb-2010
URI:
http://hdl.handle.net/10147/200331
DOI:
10.1016/S0140-6736(09)61965-6
PubMed ID:
20167359
Abstract:
Trials of statin therapy have had conflicting findings on the risk of development of diabetes mellitus in patients given statins. We aimed to establish by a meta-analysis of published and unpublished data whether any relation exists between statin use and development of diabetes.; We searched Medline, Embase, and the Cochrane Central Register of Controlled Trials from 1994 to 2009, for randomised controlled endpoint trials of statins. We included only trials with more than 1000 patients, with identical follow-up in both groups and duration of more than 1 year. We excluded trials of patients with organ transplants or who needed haemodialysis. We used the I(2) statistic to measure heterogeneity between trials and calculated risk estimates for incident diabetes with random-effect meta-analysis.; We identified 13 statin trials with 91 140 participants, of whom 4278 (2226 assigned statins and 2052 assigned control treatment) developed diabetes during a mean of 4 years. Statin therapy was associated with a 9% increased risk for incident diabetes (odds ratio [OR] 1.09; 95% CI 1.02-1.17), with little heterogeneity (I(2)=11%) between trials. Meta-regression showed that risk of development of diabetes with statins was highest in trials with older participants, but neither baseline body-mass index nor change in LDL-cholesterol concentrations accounted for residual variation in risk. Treatment of 255 (95% CI 150-852) patients with statins for 4 years resulted in one extra case of diabetes.; Statin therapy is associated with a slightly increased risk of development of diabetes, but the risk is low both in absolute terms and when compared with the reduction in coronary events. Clinical practice in patients with moderate or high cardiovascular risk or existing cardiovascular disease should not change.; None.
Item Type:
Article
Language:
en
MeSH:
Age Distribution; Age Factors; Aged; Anticholesteremic Agents; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Randomized Controlled Trials as Topic; Risk Factors; Treatment Outcome
ISSN:
1474-547X

Full metadata record

DC FieldValue Language
dc.contributor.authorSattar, Naveeden
dc.contributor.authorPreiss, Daviden
dc.contributor.authorMurray, Heather Men
dc.contributor.authorWelsh, Paulen
dc.contributor.authorBuckley, Brendan Men
dc.contributor.authorde Craen, Anton J Men
dc.contributor.authorSeshasai, Sreenivasa Rao Kondapallyen
dc.contributor.authorMcMurray, John Jen
dc.contributor.authorFreeman, Dilys Jen
dc.contributor.authorJukema, J Wouteren
dc.contributor.authorMacfarlane, Peter Wen
dc.contributor.authorPackard, Chris Jen
dc.contributor.authorStott, David Jen
dc.contributor.authorWestendorp, Rudi Gen
dc.contributor.authorShepherd, Jamesen
dc.contributor.authorDavis, Barry Ren
dc.contributor.authorPressel, Sara Len
dc.contributor.authorMarchioli, Robertoen
dc.contributor.authorMarfisi, Rosa Mariaen
dc.contributor.authorMaggioni, Aldo Pen
dc.contributor.authorTavazzi, Luigien
dc.contributor.authorTognoni, Giannien
dc.contributor.authorKjekshus, Johnen
dc.contributor.authorPedersen, Terje Ren
dc.contributor.authorCook, Thomas Jen
dc.contributor.authorGotto, Antonio Men
dc.contributor.authorClearfield, Michael Ben
dc.contributor.authorDowns, John Ren
dc.contributor.authorNakamura, Haruoen
dc.contributor.authorOhashi, Yasuoen
dc.contributor.authorMizuno, Kyoichien
dc.contributor.authorRay, Kausik Ken
dc.contributor.authorFord, Ianen
dc.date.accessioned2012-01-05T15:14:21Z-
dc.date.available2012-01-05T15:14:21Z-
dc.date.issued2010-02-27-
dc.identifier.citationStatins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. 2010, 375 (9716):735-42 Lanceten
dc.identifier.issn1474-547X-
dc.identifier.pmid20167359-
dc.identifier.doi10.1016/S0140-6736(09)61965-6-
dc.identifier.urihttp://hdl.handle.net/10147/200331-
dc.description.abstractTrials of statin therapy have had conflicting findings on the risk of development of diabetes mellitus in patients given statins. We aimed to establish by a meta-analysis of published and unpublished data whether any relation exists between statin use and development of diabetes.-
dc.description.abstractWe searched Medline, Embase, and the Cochrane Central Register of Controlled Trials from 1994 to 2009, for randomised controlled endpoint trials of statins. We included only trials with more than 1000 patients, with identical follow-up in both groups and duration of more than 1 year. We excluded trials of patients with organ transplants or who needed haemodialysis. We used the I(2) statistic to measure heterogeneity between trials and calculated risk estimates for incident diabetes with random-effect meta-analysis.-
dc.description.abstractWe identified 13 statin trials with 91 140 participants, of whom 4278 (2226 assigned statins and 2052 assigned control treatment) developed diabetes during a mean of 4 years. Statin therapy was associated with a 9% increased risk for incident diabetes (odds ratio [OR] 1.09; 95% CI 1.02-1.17), with little heterogeneity (I(2)=11%) between trials. Meta-regression showed that risk of development of diabetes with statins was highest in trials with older participants, but neither baseline body-mass index nor change in LDL-cholesterol concentrations accounted for residual variation in risk. Treatment of 255 (95% CI 150-852) patients with statins for 4 years resulted in one extra case of diabetes.-
dc.description.abstractStatin therapy is associated with a slightly increased risk of development of diabetes, but the risk is low both in absolute terms and when compared with the reduction in coronary events. Clinical practice in patients with moderate or high cardiovascular risk or existing cardiovascular disease should not change.-
dc.description.abstractNone.-
dc.language.isoenen
dc.publisherElsevieren
dc.subject.meshAge Distribution-
dc.subject.meshAge Factors-
dc.subject.meshAged-
dc.subject.meshAnticholesteremic Agents-
dc.subject.meshCardiovascular Diseases-
dc.subject.meshDiabetes Mellitus, Type 2-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshHydroxymethylglutaryl-CoA Reductase Inhibitors-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshRandomized Controlled Trials as Topic-
dc.subject.meshRisk Factors-
dc.subject.meshTreatment Outcome-
dc.titleStatins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials.en
dc.typeArticleen
dc.contributor.departmentBritish Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. nsattar@clinmed.gla.ac.uken
dc.identifier.journalLanceten
dc.description.provinceMunster-

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