Bowel preparation in CT colonography: electrolyte and renal function disturbances in the frail and elderly patient.

Hdl Handle:
http://hdl.handle.net/10147/200314
Title:
Bowel preparation in CT colonography: electrolyte and renal function disturbances in the frail and elderly patient.
Authors:
Mc Laughlin, Patrick; Eustace, Joseph; Mc Sweeney, Sean; Mc Williams, Sebastian; O'Regan, Kevin; O'Connor, Michael; Kelly, Denis; Maher, Michael M
Affiliation:
Department of Radiology, Cork University Hospital, Wilton, Cork, Ireland. mclaughlin.paddy@gmail.com
Citation:
Bowel preparation in CT colonography: electrolyte and renal function disturbances in the frail and elderly patient. 2010, 20 (3):604-12 Eur Radiol
Journal:
European radiology
Issue Date:
Mar-2010
URI:
http://hdl.handle.net/10147/200314
DOI:
10.1007/s00330-009-1575-3
PubMed ID:
19727749
Abstract:
Elderly patients are at increased risk of biochemical disturbances secondary to cathartic medications. This study investigates the renal function, electrolyte and clinical disturbances associated with CT colonography (CTC) with sodium picosulphate-magnesium citrate (SPS-MC) in a subgroup of frail, elderly patients.; Patients aged over 70 years considered at risk of complication during SPS-MC administration by a physician specialised in care of the elderly were included in this retrospective study. Biochemical parameters pre- and post-CTC and the presence of co-morbidities were recorded. Imaging findings and quality of bowel preparation at CTC were graded by consensus by two radiologists.; Of the 72 patients 56% had co-morbidities that caution the use of SPS-MC. No significant changes in serum urea, sodium, potassium or estimated glomerular filtration rate (eGFR) occurred post-CTC (p > 0.10). Serum magnesium increased by 0.11 mmol/L in 14 patients (p = 0.03) without clinical sequelae. Good overall preparation was achieved in 88% of patients, allowing confident identification of signs of colonic neoplasia in 20 patients (27%). A mild increase in serum magnesium but no other significant biochemical disturbance was observed.; In our group CTC with SPS-MC was safe and effective; however, we advise an alternate preparation be considered in patients with decreased renal function due to decreased magnesium clearance.
Item Type:
Article
Language:
en
Description:
PURPOSE: Elderly patients are at increased risk of biochemical disturbances secondary to cathartic medications. This study investigates the renal function, electrolyte and clinical disturbances associated with CT colonography (CTC) with sodium picosulphate-magnesium citrate (SPS-MC) in a subgroup of frail, elderly patients. METHODS: Patients aged over 70 years considered at risk of complication during SPS-MC administration by a physician specialised in care of the elderly were included in this retrospective study. Biochemical parameters pre- and post-CTC and the presence of co-morbidities were recorded. Imaging findings and quality of bowel preparation at CTC were graded by consensus by two radiologists. RESULTS: Of the 72 patients 56% had co-morbidities that caution the use of SPS-MC. No significant changes in serum urea, sodium, potassium or estimated glomerular filtration rate (eGFR) occurred post-CTC (p > 0.10). Serum magnesium increased by 0.11 mmol/L in 14 patients (p = 0.03) without clinical sequelae. Good overall preparation was achieved in 88% of patients, allowing confident identification of signs of colonic neoplasia in 20 patients (27%). A mild increase in serum magnesium but no other significant biochemical disturbance was observed. CONCLUSION: In our group CTC with SPS-MC was safe and effective; however, we advise an alternate preparation be considered in patients with decreased renal function due to decreased magnesium clearance.
MeSH:
Aged; Aged, 80 and over; Cathartics; Colonography, Computed Tomographic; Contrast Media; Female; Humans; Image Enhancement; Kidney Diseases; Male; Water-Electrolyte Imbalance
ISSN:
1432-1084

Full metadata record

DC FieldValue Language
dc.contributor.authorMc Laughlin, Patricken
dc.contributor.authorEustace, Josephen
dc.contributor.authorMc Sweeney, Seanen
dc.contributor.authorMc Williams, Sebastianen
dc.contributor.authorO'Regan, Kevinen
dc.contributor.authorO'Connor, Michaelen
dc.contributor.authorKelly, Denisen
dc.contributor.authorMaher, Michael Men
dc.date.accessioned2012-01-05T14:44:07Z-
dc.date.available2012-01-05T14:44:07Z-
dc.date.issued2010-03-
dc.identifier.citationBowel preparation in CT colonography: electrolyte and renal function disturbances in the frail and elderly patient. 2010, 20 (3):604-12 Eur Radiolen
dc.identifier.issn1432-1084-
dc.identifier.pmid19727749-
dc.identifier.doi10.1007/s00330-009-1575-3-
dc.identifier.urihttp://hdl.handle.net/10147/200314-
dc.descriptionPURPOSE: Elderly patients are at increased risk of biochemical disturbances secondary to cathartic medications. This study investigates the renal function, electrolyte and clinical disturbances associated with CT colonography (CTC) with sodium picosulphate-magnesium citrate (SPS-MC) in a subgroup of frail, elderly patients. METHODS: Patients aged over 70 years considered at risk of complication during SPS-MC administration by a physician specialised in care of the elderly were included in this retrospective study. Biochemical parameters pre- and post-CTC and the presence of co-morbidities were recorded. Imaging findings and quality of bowel preparation at CTC were graded by consensus by two radiologists. RESULTS: Of the 72 patients 56% had co-morbidities that caution the use of SPS-MC. No significant changes in serum urea, sodium, potassium or estimated glomerular filtration rate (eGFR) occurred post-CTC (p > 0.10). Serum magnesium increased by 0.11 mmol/L in 14 patients (p = 0.03) without clinical sequelae. Good overall preparation was achieved in 88% of patients, allowing confident identification of signs of colonic neoplasia in 20 patients (27%). A mild increase in serum magnesium but no other significant biochemical disturbance was observed. CONCLUSION: In our group CTC with SPS-MC was safe and effective; however, we advise an alternate preparation be considered in patients with decreased renal function due to decreased magnesium clearance.en
dc.description.abstractElderly patients are at increased risk of biochemical disturbances secondary to cathartic medications. This study investigates the renal function, electrolyte and clinical disturbances associated with CT colonography (CTC) with sodium picosulphate-magnesium citrate (SPS-MC) in a subgroup of frail, elderly patients.-
dc.description.abstractPatients aged over 70 years considered at risk of complication during SPS-MC administration by a physician specialised in care of the elderly were included in this retrospective study. Biochemical parameters pre- and post-CTC and the presence of co-morbidities were recorded. Imaging findings and quality of bowel preparation at CTC were graded by consensus by two radiologists.-
dc.description.abstractOf the 72 patients 56% had co-morbidities that caution the use of SPS-MC. No significant changes in serum urea, sodium, potassium or estimated glomerular filtration rate (eGFR) occurred post-CTC (p > 0.10). Serum magnesium increased by 0.11 mmol/L in 14 patients (p = 0.03) without clinical sequelae. Good overall preparation was achieved in 88% of patients, allowing confident identification of signs of colonic neoplasia in 20 patients (27%). A mild increase in serum magnesium but no other significant biochemical disturbance was observed.-
dc.description.abstractIn our group CTC with SPS-MC was safe and effective; however, we advise an alternate preparation be considered in patients with decreased renal function due to decreased magnesium clearance.-
dc.language.isoenen
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshCathartics-
dc.subject.meshColonography, Computed Tomographic-
dc.subject.meshContrast Media-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImage Enhancement-
dc.subject.meshKidney Diseases-
dc.subject.meshMale-
dc.subject.meshWater-Electrolyte Imbalance-
dc.titleBowel preparation in CT colonography: electrolyte and renal function disturbances in the frail and elderly patient.en
dc.typeArticleen
dc.contributor.departmentDepartment of Radiology, Cork University Hospital, Wilton, Cork, Ireland. mclaughlin.paddy@gmail.comen
dc.identifier.journalEuropean radiologyen
dc.description.provinceMunster-

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