Hyponatremia independent of osteoporosis is associated with fracture occurrence.

Hdl Handle:
http://hdl.handle.net/10147/200312
Title:
Hyponatremia independent of osteoporosis is associated with fracture occurrence.
Authors:
Kinsella, Sinead; Moran, Sarah; Sullivan, Miriam O; Molloy, Michael G M; Eustace, Joseph A
Affiliation:
Department of Nephrology, Cork University Hospital, Cork, Ireland.
Citation:
Hyponatremia independent of osteoporosis is associated with fracture occurrence. 2010, 5 (2):275-80 Clin J Am Soc Nephrol
Journal:
Clinical journal of the American Society of Nephrology : CJASN
Issue Date:
Feb-2010
URI:
http://hdl.handle.net/10147/200312
DOI:
10.2215/CJN.06120809
PubMed ID:
20056759
Additional Links:
http://cjasn.asnjournals.org/content/5/2/275.full.pdf+html; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827601/?report=printable
Abstract:
Mild hyponatremia has traditionally been considered benign, but it may be associated with gait and attention deficits and an increased risk of falls that may result in fracture. A retrospective study was conducted to quantify the association of hyponatremia with fracture occurrence and to examine whether this relationship is independent of osteoporosis.; This study analyzed 1408 consecutive female patients who underwent bone mineral density measurement (Lunar IDXA) between September 1, 2006 and April 11, 2007 and who had available laboratory data. Self reported fracture occurrence was confirmed by radiology report or attendance at a fracture clinic. The significance and independence of the association of hyponatremia with fracture was quantified using logistic regression.; The mean (SD) serum sodium ([Na(+)]) was 140.6 (3.0) mmol/L; 59 (4.2%) had [Na(+)] < 135 mmol/L. Forty-five percent of subjects were osteoporotic and 18% had a prior fracture. Hyponatremia was present in 8.7% of those with versus 3.2% of those without a confirmed fracture (P < 0.001). On multivariate logistic regression analysis controlling for age, T-score, chronic kidney disease stage, osteoporotic risk factors (amenorrhea, family history, regular steroid use, smoking history, alcohol use, history of liver disease, and low-calcium diet), and osteoporosis treatments (calcium and vitamin D supplements, antiresorptives, and hormonal replacement therapy), [Na(+)] < 135 versus [Na(+)] >or= 135 mmol/L remained significantly and independently associated with fracture occurrence (P < 0.01).; Mild hyponatremia may be a readily identifiable and potentially modifiable risk factor for fracture.
Item Type:
Article
Language:
en
Description:
BACKGROUND AND OBJECTIVES: Mild hyponatremia has traditionally been considered benign, but it may be associated with gait and attention deficits and an increased risk of falls that may result in fracture. A retrospective study was conducted to quantify the association of hyponatremia with fracture occurrence and to examine whether this relationship is independent of osteoporosis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study analyzed 1408 consecutive female patients who underwent bone mineral density measurement (Lunar IDXA) between September 1, 2006 and April 11, 2007 and who had available laboratory data. Self reported fracture occurrence was confirmed by radiology report or attendance at a fracture clinic. The significance and independence of the association of hyponatremia with fracture was quantified using logistic regression. RESULTS: The mean (SD) serum sodium ([Na(+)]) was 140.6 (3.0) mmol/L; 59 (4.2%) had [Na(+)] < 135 mmol/L. Forty-five percent of subjects were osteoporotic and 18% had a prior fracture. Hyponatremia was present in 8.7% of those with versus 3.2% of those without a confirmed fracture (P < 0.001). On multivariate logistic regression analysis controlling for age, T-score, chronic kidney disease stage, osteoporotic risk factors (amenorrhea, family history, regular steroid use, smoking history, alcohol use, history of liver disease, and low-calcium diet), and osteoporosis treatments (calcium and vitamin D supplements, antiresorptives, and hormonal replacement therapy), [Na(+)] < 135 versus [Na(+)] >or= 135 mmol/L remained significantly and independently associated with fracture occurrence (P < 0.01). CONCLUSIONS: Mild hyponatremia may be a readily identifiable and potentially modifiable risk factor for fracture.
MeSH:
Absorptiometry, Photon; Accidental Falls; Adult; Aged; Aged, 80 and over; Biological Markers; Bone Density; Chi-Square Distribution; Female; Fractures, Bone; Gait Disorders, Neurologic; Humans; Hyponatremia; Logistic Models; Middle Aged; Odds Ratio; Osteoporosis; Retrospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; Sodium; Young Adult
ISSN:
1555-905X

Full metadata record

DC FieldValue Language
dc.contributor.authorKinsella, Sineaden
dc.contributor.authorMoran, Sarahen
dc.contributor.authorSullivan, Miriam Oen
dc.contributor.authorMolloy, Michael G Men
dc.contributor.authorEustace, Joseph Aen
dc.date.accessioned2012-01-05T14:28:56Z-
dc.date.available2012-01-05T14:28:56Z-
dc.date.issued2010-02-
dc.identifier.citationHyponatremia independent of osteoporosis is associated with fracture occurrence. 2010, 5 (2):275-80 Clin J Am Soc Nephrolen
dc.identifier.issn1555-905X-
dc.identifier.pmid20056759-
dc.identifier.doi10.2215/CJN.06120809-
dc.identifier.urihttp://hdl.handle.net/10147/200312-
dc.descriptionBACKGROUND AND OBJECTIVES: Mild hyponatremia has traditionally been considered benign, but it may be associated with gait and attention deficits and an increased risk of falls that may result in fracture. A retrospective study was conducted to quantify the association of hyponatremia with fracture occurrence and to examine whether this relationship is independent of osteoporosis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study analyzed 1408 consecutive female patients who underwent bone mineral density measurement (Lunar IDXA) between September 1, 2006 and April 11, 2007 and who had available laboratory data. Self reported fracture occurrence was confirmed by radiology report or attendance at a fracture clinic. The significance and independence of the association of hyponatremia with fracture was quantified using logistic regression. RESULTS: The mean (SD) serum sodium ([Na(+)]) was 140.6 (3.0) mmol/L; 59 (4.2%) had [Na(+)] < 135 mmol/L. Forty-five percent of subjects were osteoporotic and 18% had a prior fracture. Hyponatremia was present in 8.7% of those with versus 3.2% of those without a confirmed fracture (P < 0.001). On multivariate logistic regression analysis controlling for age, T-score, chronic kidney disease stage, osteoporotic risk factors (amenorrhea, family history, regular steroid use, smoking history, alcohol use, history of liver disease, and low-calcium diet), and osteoporosis treatments (calcium and vitamin D supplements, antiresorptives, and hormonal replacement therapy), [Na(+)] < 135 versus [Na(+)] >or= 135 mmol/L remained significantly and independently associated with fracture occurrence (P < 0.01). CONCLUSIONS: Mild hyponatremia may be a readily identifiable and potentially modifiable risk factor for fracture.en
dc.description.abstractMild hyponatremia has traditionally been considered benign, but it may be associated with gait and attention deficits and an increased risk of falls that may result in fracture. A retrospective study was conducted to quantify the association of hyponatremia with fracture occurrence and to examine whether this relationship is independent of osteoporosis.-
dc.description.abstractThis study analyzed 1408 consecutive female patients who underwent bone mineral density measurement (Lunar IDXA) between September 1, 2006 and April 11, 2007 and who had available laboratory data. Self reported fracture occurrence was confirmed by radiology report or attendance at a fracture clinic. The significance and independence of the association of hyponatremia with fracture was quantified using logistic regression.-
dc.description.abstractThe mean (SD) serum sodium ([Na(+)]) was 140.6 (3.0) mmol/L; 59 (4.2%) had [Na(+)] < 135 mmol/L. Forty-five percent of subjects were osteoporotic and 18% had a prior fracture. Hyponatremia was present in 8.7% of those with versus 3.2% of those without a confirmed fracture (P < 0.001). On multivariate logistic regression analysis controlling for age, T-score, chronic kidney disease stage, osteoporotic risk factors (amenorrhea, family history, regular steroid use, smoking history, alcohol use, history of liver disease, and low-calcium diet), and osteoporosis treatments (calcium and vitamin D supplements, antiresorptives, and hormonal replacement therapy), [Na(+)] < 135 versus [Na(+)] >or= 135 mmol/L remained significantly and independently associated with fracture occurrence (P < 0.01).-
dc.description.abstractMild hyponatremia may be a readily identifiable and potentially modifiable risk factor for fracture.-
dc.language.isoenen
dc.relation.urlhttp://cjasn.asnjournals.org/content/5/2/275.full.pdf+htmlen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827601/?report=printableen
dc.subject.meshAbsorptiometry, Photon-
dc.subject.meshAccidental Falls-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshBiological Markers-
dc.subject.meshBone Density-
dc.subject.meshChi-Square Distribution-
dc.subject.meshFemale-
dc.subject.meshFractures, Bone-
dc.subject.meshGait Disorders, Neurologic-
dc.subject.meshHumans-
dc.subject.meshHyponatremia-
dc.subject.meshLogistic Models-
dc.subject.meshMiddle Aged-
dc.subject.meshOdds Ratio-
dc.subject.meshOsteoporosis-
dc.subject.meshRetrospective Studies-
dc.subject.meshRisk Assessment-
dc.subject.meshRisk Factors-
dc.subject.meshSeverity of Illness Index-
dc.subject.meshSodium-
dc.subject.meshYoung Adult-
dc.titleHyponatremia independent of osteoporosis is associated with fracture occurrence.en
dc.typeArticleen
dc.contributor.departmentDepartment of Nephrology, Cork University Hospital, Cork, Ireland.en
dc.identifier.journalClinical journal of the American Society of Nephrology : CJASNen
dc.description.provinceMunster-

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