Perioperative pregabalin improves pain and functional outcomes 3 months after lumbar discectomy.

Hdl Handle:
http://hdl.handle.net/10147/200311
Title:
Perioperative pregabalin improves pain and functional outcomes 3 months after lumbar discectomy.
Authors:
Burke, Siun M; Shorten, George D
Affiliation:
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, Wilton, Cork, Ireland. siunburke@hotmail.com
Citation:
Perioperative pregabalin improves pain and functional outcomes 3 months after lumbar discectomy. 2010, 110 (4):1180-5 Anesth. Analg.
Journal:
Anesthesia and analgesia
Issue Date:
1-Apr-2010
URI:
http://hdl.handle.net/10147/200311
DOI:
10.1213/ANE.0b013e3181cf949a
PubMed ID:
20103545
Additional Links:
http://www.anesthesia-analgesia.org/content/110/4/1180.full.pdf+html
Abstract:
Patient outcome after lumbar discectomy for radicular low back pain is variable and the benefit is inconsistent. Many patients continue to experience pain 3 months after surgery. Pregabalin, a membrane stabilizer, may decrease perioperative central sensitization and subsequent persistent pain.; Forty patients undergoing lumbar discectomy were randomly allocated to receive either pregabalin (300 mg at 90 minutes preoperatively and 150 mg at 12 and 24 hours postoperatively) or placebo at corresponding times in a double-blinded manner. Our primary outcome was the change in the present pain intensity (PPI) (visual analog scale [VAS], 0-100 mm [PPI-VAS, McGill Pain Questionnaire]) from preoperatively to 3 months postoperatively.; The decrease in PPI-VAS score at 3 months was greater in patients who received pregabalin (37.6 +/- 19.6 mm) (mean +/- sd) than those who received placebo (25.3 +/- 21.9 mm) (P = 0.08). The Roland Morris disability score at 3 months was less in patients who received pregabalin (2.7 +/- 2.4) than in those who received placebo (5.6 +/- 4.8) (P = 0.032). Pregabalin administration was associated with greater pain tolerance thresholds in both lower limbs compared with placebo at 24 hours postoperatively.; Perioperative pregabalin administration is associated with less pain intensity and improved functional outcomes 3 months after lumbar discectomy.
Item Type:
Article
Language:
en
Description:
BACKGROUND: Patient outcome after lumbar discectomy for radicular low back pain is variable and the benefit is inconsistent. Many patients continue to experience pain 3 months after surgery. Pregabalin, a membrane stabilizer, may decrease perioperative central sensitization and subsequent persistent pain. METHODS: Forty patients undergoing lumbar discectomy were randomly allocated to receive either pregabalin (300 mg at 90 minutes preoperatively and 150 mg at 12 and 24 hours postoperatively) or placebo at corresponding times in a double-blinded manner. Our primary outcome was the change in the present pain intensity (PPI) (visual analog scale [VAS], 0-100 mm [PPI-VAS, McGill Pain Questionnaire]) from preoperatively to 3 months postoperatively. RESULTS: The decrease in PPI-VAS score at 3 months was greater in patients who received pregabalin (37.6 +/- 19.6 mm) (mean +/- sd) than those who received placebo (25.3 +/- 21.9 mm) (P = 0.08). The Roland Morris disability score at 3 months was less in patients who received pregabalin (2.7 +/- 2.4) than in those who received placebo (5.6 +/- 4.8) (P = 0.032). Pregabalin administration was associated with greater pain tolerance thresholds in both lower limbs compared with placebo at 24 hours postoperatively. CONCLUSION: Perioperative pregabalin administration is associated with less pain intensity and improved functional outcomes 3 months after lumbar discectomy.
MeSH:
Adolescent; Adult; Analgesics; Anesthesia; DNA; Diskectomy; Double-Blind Method; Electric Stimulation; Female; Hemodynamics; Humans; Male; Middle Aged; Pain Measurement; Pain Threshold; Pain, Postoperative; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; Treatment Outcome; Young Adult; gamma-Aminobutyric Acid
ISSN:
1526-7598

Full metadata record

DC FieldValue Language
dc.contributor.authorBurke, Siun Men
dc.contributor.authorShorten, George Den
dc.date.accessioned2012-01-05T14:16:54Z-
dc.date.available2012-01-05T14:16:54Z-
dc.date.issued2010-04-01-
dc.identifier.citationPerioperative pregabalin improves pain and functional outcomes 3 months after lumbar discectomy. 2010, 110 (4):1180-5 Anesth. Analg.en
dc.identifier.issn1526-7598-
dc.identifier.pmid20103545-
dc.identifier.doi10.1213/ANE.0b013e3181cf949a-
dc.identifier.urihttp://hdl.handle.net/10147/200311-
dc.descriptionBACKGROUND: Patient outcome after lumbar discectomy for radicular low back pain is variable and the benefit is inconsistent. Many patients continue to experience pain 3 months after surgery. Pregabalin, a membrane stabilizer, may decrease perioperative central sensitization and subsequent persistent pain. METHODS: Forty patients undergoing lumbar discectomy were randomly allocated to receive either pregabalin (300 mg at 90 minutes preoperatively and 150 mg at 12 and 24 hours postoperatively) or placebo at corresponding times in a double-blinded manner. Our primary outcome was the change in the present pain intensity (PPI) (visual analog scale [VAS], 0-100 mm [PPI-VAS, McGill Pain Questionnaire]) from preoperatively to 3 months postoperatively. RESULTS: The decrease in PPI-VAS score at 3 months was greater in patients who received pregabalin (37.6 +/- 19.6 mm) (mean +/- sd) than those who received placebo (25.3 +/- 21.9 mm) (P = 0.08). The Roland Morris disability score at 3 months was less in patients who received pregabalin (2.7 +/- 2.4) than in those who received placebo (5.6 +/- 4.8) (P = 0.032). Pregabalin administration was associated with greater pain tolerance thresholds in both lower limbs compared with placebo at 24 hours postoperatively. CONCLUSION: Perioperative pregabalin administration is associated with less pain intensity and improved functional outcomes 3 months after lumbar discectomy.en
dc.description.abstractPatient outcome after lumbar discectomy for radicular low back pain is variable and the benefit is inconsistent. Many patients continue to experience pain 3 months after surgery. Pregabalin, a membrane stabilizer, may decrease perioperative central sensitization and subsequent persistent pain.-
dc.description.abstractForty patients undergoing lumbar discectomy were randomly allocated to receive either pregabalin (300 mg at 90 minutes preoperatively and 150 mg at 12 and 24 hours postoperatively) or placebo at corresponding times in a double-blinded manner. Our primary outcome was the change in the present pain intensity (PPI) (visual analog scale [VAS], 0-100 mm [PPI-VAS, McGill Pain Questionnaire]) from preoperatively to 3 months postoperatively.-
dc.description.abstractThe decrease in PPI-VAS score at 3 months was greater in patients who received pregabalin (37.6 +/- 19.6 mm) (mean +/- sd) than those who received placebo (25.3 +/- 21.9 mm) (P = 0.08). The Roland Morris disability score at 3 months was less in patients who received pregabalin (2.7 +/- 2.4) than in those who received placebo (5.6 +/- 4.8) (P = 0.032). Pregabalin administration was associated with greater pain tolerance thresholds in both lower limbs compared with placebo at 24 hours postoperatively.-
dc.description.abstractPerioperative pregabalin administration is associated with less pain intensity and improved functional outcomes 3 months after lumbar discectomy.-
dc.language.isoenen
dc.relation.urlhttp://www.anesthesia-analgesia.org/content/110/4/1180.full.pdf+htmlen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAnalgesics-
dc.subject.meshAnesthesia-
dc.subject.meshDNA-
dc.subject.meshDiskectomy-
dc.subject.meshDouble-Blind Method-
dc.subject.meshElectric Stimulation-
dc.subject.meshFemale-
dc.subject.meshHemodynamics-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshPain Measurement-
dc.subject.meshPain Threshold-
dc.subject.meshPain, Postoperative-
dc.subject.meshReceptors, Opioid, mu-
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction-
dc.subject.meshTreatment Outcome-
dc.subject.meshYoung Adult-
dc.subject.meshgamma-Aminobutyric Acid-
dc.titlePerioperative pregabalin improves pain and functional outcomes 3 months after lumbar discectomy.en
dc.typeArticleen
dc.contributor.departmentDepartment of Anaesthesia and Intensive Care Medicine, Cork University Hospital, Wilton, Cork, Ireland. siunburke@hotmail.comen
dc.identifier.journalAnesthesia and analgesiaen
dc.description.provinceMunster-
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