Emergence of MRSA clone ST22 in healthy young adults in the community in the absence of risk factors.

Hdl Handle:
http://hdl.handle.net/10147/200273
Title:
Emergence of MRSA clone ST22 in healthy young adults in the community in the absence of risk factors.
Authors:
Mollaghan, A M; Lucey, B; Coffey, A; Cotter, L
Affiliation:
Department of Biological Sciences, Cork Institute of Technology, Bishopstown, Cork, Ireland.
Citation:
Emergence of MRSA clone ST22 in healthy young adults in the community in the absence of risk factors. 2010, 138 (5):673-6 Epidemiol. Infect.
Journal:
Epidemiology and infection
Issue Date:
May-2010
URI:
http://hdl.handle.net/10147/200273
DOI:
10.1017/S0950268810000191
PubMed ID:
20144250
Abstract:
One thousand adults aged between 18 and 35 years were investigated for nasal colonization with community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). Each volunteer completed a questionnaire to assess the presence or absence of risk factors for hospital-acquired MRSA (HA-MRSA) carriage. All MRSA isolated were characterized by microbiological and molecular methods. A S. aureus carriage rate of 22% and a MRSA carriage rate of 0.7% were observed. Analysis of the questionnaires revealed 121 individuals with HA-MRSA risk factors. Subsequently two MRSA infections with associated risk factors were excluded from calculation of the true carriage rate and an adjusted rate of 0.57% (5/879) was established. All seven MRSA isolates expressed the genotypic profile ST22-MRSA-IV, were PVL negative, agr type 1, and differed only by their antimicrobial susceptibility patterns. ST22-MRSA-IV (EMRSA-15) has shown worldwide spread in the hospital setting but has not been previously documented in isolation in the community.
Item Type:
Article
Language:
en
Description:
One thousand adults aged between 18 and 35 years were investigated for nasal colonization with community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). Each volunteer completed a questionnaire to assess the presence or absence of risk factors for hospital-acquired MRSA (HA-MRSA) carriage. All MRSA isolated were characterized by microbiological and molecular methods. A S. aureus carriage rate of 22% and a MRSA carriage rate of 0.7% were observed. Analysis of the questionnaires revealed 121 individuals with HA-MRSA risk factors. Subsequently two MRSA infections with associated risk factors were excluded from calculation of the true carriage rate and an adjusted rate of 0.57% (5/879) was established. All seven MRSA isolates expressed the genotypic profile ST22-MRSA-IV, were PVL negative, agr type 1, and differed only by their antimicrobial susceptibility patterns. ST22-MRSA-IV (EMRSA-15) has shown worldwide spread in the hospital setting but has not been previously documented in isolation in the community.
MeSH:
Adolescent; Adult; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Carrier State; Community-Acquired Infections; DNA Fingerprinting; DNA, Bacterial; Exotoxins; Female; Genotype; Human Experimentation; Humans; Leukocidins; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Nose; Prevalence; Questionnaires; Risk Factors; Staphylococcal Infections; Trans-Activators; Virulence Factors; Young Adult
ISSN:
1469-4409

Full metadata record

DC FieldValue Language
dc.contributor.authorMollaghan, A Men
dc.contributor.authorLucey, Ben
dc.contributor.authorCoffey, Aen
dc.contributor.authorCotter, Len
dc.date.accessioned2012-01-05T14:06:40Z-
dc.date.available2012-01-05T14:06:40Z-
dc.date.issued2010-05-
dc.identifier.citationEmergence of MRSA clone ST22 in healthy young adults in the community in the absence of risk factors. 2010, 138 (5):673-6 Epidemiol. Infect.en
dc.identifier.issn1469-4409-
dc.identifier.pmid20144250-
dc.identifier.doi10.1017/S0950268810000191-
dc.identifier.urihttp://hdl.handle.net/10147/200273-
dc.descriptionOne thousand adults aged between 18 and 35 years were investigated for nasal colonization with community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). Each volunteer completed a questionnaire to assess the presence or absence of risk factors for hospital-acquired MRSA (HA-MRSA) carriage. All MRSA isolated were characterized by microbiological and molecular methods. A S. aureus carriage rate of 22% and a MRSA carriage rate of 0.7% were observed. Analysis of the questionnaires revealed 121 individuals with HA-MRSA risk factors. Subsequently two MRSA infections with associated risk factors were excluded from calculation of the true carriage rate and an adjusted rate of 0.57% (5/879) was established. All seven MRSA isolates expressed the genotypic profile ST22-MRSA-IV, were PVL negative, agr type 1, and differed only by their antimicrobial susceptibility patterns. ST22-MRSA-IV (EMRSA-15) has shown worldwide spread in the hospital setting but has not been previously documented in isolation in the community.en
dc.description.abstractOne thousand adults aged between 18 and 35 years were investigated for nasal colonization with community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). Each volunteer completed a questionnaire to assess the presence or absence of risk factors for hospital-acquired MRSA (HA-MRSA) carriage. All MRSA isolated were characterized by microbiological and molecular methods. A S. aureus carriage rate of 22% and a MRSA carriage rate of 0.7% were observed. Analysis of the questionnaires revealed 121 individuals with HA-MRSA risk factors. Subsequently two MRSA infections with associated risk factors were excluded from calculation of the true carriage rate and an adjusted rate of 0.57% (5/879) was established. All seven MRSA isolates expressed the genotypic profile ST22-MRSA-IV, were PVL negative, agr type 1, and differed only by their antimicrobial susceptibility patterns. ST22-MRSA-IV (EMRSA-15) has shown worldwide spread in the hospital setting but has not been previously documented in isolation in the community.-
dc.language.isoenen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshBacterial Proteins-
dc.subject.meshBacterial Toxins-
dc.subject.meshBacterial Typing Techniques-
dc.subject.meshCarrier State-
dc.subject.meshCommunity-Acquired Infections-
dc.subject.meshDNA Fingerprinting-
dc.subject.meshDNA, Bacterial-
dc.subject.meshExotoxins-
dc.subject.meshFemale-
dc.subject.meshGenotype-
dc.subject.meshHuman Experimentation-
dc.subject.meshHumans-
dc.subject.meshLeukocidins-
dc.subject.meshMale-
dc.subject.meshMethicillin-Resistant Staphylococcus aureus-
dc.subject.meshMicrobial Sensitivity Tests-
dc.subject.meshNose-
dc.subject.meshPrevalence-
dc.subject.meshQuestionnaires-
dc.subject.meshRisk Factors-
dc.subject.meshStaphylococcal Infections-
dc.subject.meshTrans-Activators-
dc.subject.meshVirulence Factors-
dc.subject.meshYoung Adult-
dc.titleEmergence of MRSA clone ST22 in healthy young adults in the community in the absence of risk factors.en
dc.typeArticleen
dc.contributor.departmentDepartment of Biological Sciences, Cork Institute of Technology, Bishopstown, Cork, Ireland.en
dc.identifier.journalEpidemiology and infectionen
dc.description.provinceMunster-
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