The antiendotoxin agent taurolidine potentially reduces ischemia/reperfusion injury through its metabolite taurine.

Hdl Handle:
http://hdl.handle.net/10147/200243
Title:
The antiendotoxin agent taurolidine potentially reduces ischemia/reperfusion injury through its metabolite taurine.
Authors:
Doddakula, Kishore K; Neary, Peter M; Wang, Jiang H; Sookhai, Shastri; O'Donnell, Aongus; Aherne, Tom; Bouchier-Hayes, David J; Redmond, Henry P
Affiliation:
Department of Cardiac Surgery, University College Cork, Cork University Hospital, Cork, Ireland.
Citation:
The antiendotoxin agent taurolidine potentially reduces ischemia/reperfusion injury through its metabolite taurine. 2010, 148 (3):567-72 Surgery
Publisher:
Mosby Inc.
Journal:
Surgery
Issue Date:
Sep-2010
URI:
http://hdl.handle.net/10147/200243
DOI:
10.1016/j.surg.2010.01.006
PubMed ID:
20223497
Abstract:
Cardiopulmonary bypass results in ischemia/reperfusion (I/R)-induced endotoxemia. We conducted a prospective randomized trial to investigate the effect of taurolidine, an antiendotoxin agent with antioxidant and membrane-stabilizing properties, on patients undergoing coronary artery bypass grafting (CABG).; A total of 60 patients undergoing CABG were randomized into 4 groups. St Thomas' Hospital cold crystalloid cardioplegia was used in groups A and B, and cold blood cardioplegia in groups C and D. Groups A and C received a placebo infusion of normal saline, whereas groups B and D were administered intravenous taurolidine. Arrhythmias induced by pro- and anti-inflammatory cytokines (interleukin [IL]-6 and IL-10), and I/R were assessed perioperatively.; Administration of taurolidine in crystalloid cardioplegia patients resulted in a significant decrease in serum IL-6 and an increase in serum IL-10 at 24 hours postaortic unclamping compared to placebo (P < .0001). Although not statistically significant, this trend in serum IL-6 decrease was mirrored in the blood cardioplegia patients (P = .068). Taurolidine treatment also significantly decreased I/R-induced arrhythmias compared to placebo in the crystalloid cardioplegia patients (P < .003). There were fewer I/R-induced arrhythmias compared to placebo in the blood cardioplegia patients; the difference, however, was marginal and not statistically significant (P = .583).; This study demonstrates that administration of taurolidine in CABG patients induces a potent anti-inflammatory response that is associated with a significant decrease in arrhythmias.
Item Type:
Article
Language:
en
MeSH:
Aged; Antioxidants; Cardiopulmonary Bypass; Constriction; Coronary Artery Bypass; Endotoxins; Female; Heart Arrest, Induced; Humans; Interleukin-10; Interleukin-6; Length of Stay; Male; Middle Aged; Phagocytosis; Placebos; Reperfusion Injury; Respiratory Burst; Taurine
ISSN:
1532-7361

Full metadata record

DC FieldValue Language
dc.contributor.authorDoddakula, Kishore Ken
dc.contributor.authorNeary, Peter Men
dc.contributor.authorWang, Jiang Hen
dc.contributor.authorSookhai, Shastrien
dc.contributor.authorO'Donnell, Aongusen
dc.contributor.authorAherne, Tomen
dc.contributor.authorBouchier-Hayes, David Jen
dc.contributor.authorRedmond, Henry Pen
dc.date.accessioned2012-01-05T12:24:13Z-
dc.date.available2012-01-05T12:24:13Z-
dc.date.issued2010-09-
dc.identifier.citationThe antiendotoxin agent taurolidine potentially reduces ischemia/reperfusion injury through its metabolite taurine. 2010, 148 (3):567-72 Surgeryen
dc.identifier.issn1532-7361-
dc.identifier.pmid20223497-
dc.identifier.doi10.1016/j.surg.2010.01.006-
dc.identifier.urihttp://hdl.handle.net/10147/200243-
dc.description.abstractCardiopulmonary bypass results in ischemia/reperfusion (I/R)-induced endotoxemia. We conducted a prospective randomized trial to investigate the effect of taurolidine, an antiendotoxin agent with antioxidant and membrane-stabilizing properties, on patients undergoing coronary artery bypass grafting (CABG).-
dc.description.abstractA total of 60 patients undergoing CABG were randomized into 4 groups. St Thomas' Hospital cold crystalloid cardioplegia was used in groups A and B, and cold blood cardioplegia in groups C and D. Groups A and C received a placebo infusion of normal saline, whereas groups B and D were administered intravenous taurolidine. Arrhythmias induced by pro- and anti-inflammatory cytokines (interleukin [IL]-6 and IL-10), and I/R were assessed perioperatively.-
dc.description.abstractAdministration of taurolidine in crystalloid cardioplegia patients resulted in a significant decrease in serum IL-6 and an increase in serum IL-10 at 24 hours postaortic unclamping compared to placebo (P < .0001). Although not statistically significant, this trend in serum IL-6 decrease was mirrored in the blood cardioplegia patients (P = .068). Taurolidine treatment also significantly decreased I/R-induced arrhythmias compared to placebo in the crystalloid cardioplegia patients (P < .003). There were fewer I/R-induced arrhythmias compared to placebo in the blood cardioplegia patients; the difference, however, was marginal and not statistically significant (P = .583).-
dc.description.abstractThis study demonstrates that administration of taurolidine in CABG patients induces a potent anti-inflammatory response that is associated with a significant decrease in arrhythmias.-
dc.language.isoenen
dc.publisherMosby Inc.en
dc.subject.meshAged-
dc.subject.meshAntioxidants-
dc.subject.meshCardiopulmonary Bypass-
dc.subject.meshConstriction-
dc.subject.meshCoronary Artery Bypass-
dc.subject.meshEndotoxins-
dc.subject.meshFemale-
dc.subject.meshHeart Arrest, Induced-
dc.subject.meshHumans-
dc.subject.meshInterleukin-10-
dc.subject.meshInterleukin-6-
dc.subject.meshLength of Stay-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshPhagocytosis-
dc.subject.meshPlacebos-
dc.subject.meshReperfusion Injury-
dc.subject.meshRespiratory Burst-
dc.subject.meshTaurine-
dc.titleThe antiendotoxin agent taurolidine potentially reduces ischemia/reperfusion injury through its metabolite taurine.en
dc.typeArticleen
dc.contributor.departmentDepartment of Cardiac Surgery, University College Cork, Cork University Hospital, Cork, Ireland.en
dc.identifier.journalSurgeryen
dc.description.provinceMunster-

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