Moderate chronic kidney disease in women is associated with fracture occurrence independently of osteoporosis.

Hdl Handle:
http://hdl.handle.net/10147/200234
Title:
Moderate chronic kidney disease in women is associated with fracture occurrence independently of osteoporosis.
Authors:
Kinsella, Sinead; Chavrimootoo, Shawn; Molloy, Michael G; Eustace, Joseph A
Affiliation:
Department of Nephrology, Cork University Hospital, Cork, Ireland.
Citation:
Moderate chronic kidney disease in women is associated with fracture occurrence independently of osteoporosis. 2010, 116 (3):c256-62 Nephron Clin Pract
Publisher:
Karger
Journal:
Nephron. Clinical practice
Issue Date:
2010
URI:
http://hdl.handle.net/10147/200234
DOI:
10.1159/000317207
PubMed ID:
20606487
Abstract:
Chronic kidney disease (CKD) is associated with increased risk of fragility fracture but whether this is independent of osteoporosis is unclear.; We conducted a retrospective cross-sectional study of 1,702 female patients referred for dual-energy X-ray absorptiometry (DXA) scanning (Lunar IDXA) between September 2006 and April 2007. Estimated glomerular filtration rate (eGFR; ml/min/1.73 m(2)) by Modification of Diet in Renal Disease was calculated within 1 year (median interval 4 weeks) of the DXA scan. The independent association of self-reported fracture occurrence with eGFR category was assessed using multivariate logistic regression.; Mean age (SD) was 61.7 (10.8) years; mean eGFR (SD) was 68.8 (12.2). The percentages of subjects with an eGFR of 75-89, 60-74, 30-59 and <30 was 34, 45, 20 and 0.8%, respectively. Forty-seven percent had osteoporosis. Mean T scores for the above eGFR categories were -2.2, -2.3, -2.5 and -3.0, respectively (p trend <0.001). Osteoporosis was significantly associated with eGFR on univariate analysis but not following adjustment for age. The percentage of patients with a fracture (29%) and with multiple prior fractures (3.5%) was higher at lower eGFR (p < 0.001, χ(2) test). The adjusted odds ratios (95% confidence interval) of any prior fracture for eGFR 75-89, 60-74 and 30-59 were 1.0 (reference), 1.2 (0.9-1.6) and 1.4 (1.0-1.9), respectively, adjusting simultaneously for age, T score, risk factors and treatment for osteoporosis.; Moderate CKD is a significant independent predictor of fracture occurrence.
Item Type:
Article
Language:
en
MeSH:
Absorptiometry, Photon; Adult; Aged; Aged, 80 and over; Bone Density; Chronic Disease; Cross-Sectional Studies; Female; Fractures, Bone; Fractures, Spontaneous; Glomerular Filtration Rate; Humans; Ireland; Kidney Diseases; Middle Aged; Minerals; Osteoporosis; Retrospective Studies; Risk; Young Adult
ISSN:
1660-2110

Full metadata record

DC FieldValue Language
dc.contributor.authorKinsella, Sineaden
dc.contributor.authorChavrimootoo, Shawnen
dc.contributor.authorMolloy, Michael Gen
dc.contributor.authorEustace, Joseph Aen
dc.date.accessioned2012-01-05T12:02:30Z-
dc.date.available2012-01-05T12:02:30Z-
dc.date.issued2010-
dc.identifier.citationModerate chronic kidney disease in women is associated with fracture occurrence independently of osteoporosis. 2010, 116 (3):c256-62 Nephron Clin Practen
dc.identifier.issn1660-2110-
dc.identifier.pmid20606487-
dc.identifier.doi10.1159/000317207-
dc.identifier.urihttp://hdl.handle.net/10147/200234-
dc.description.abstractChronic kidney disease (CKD) is associated with increased risk of fragility fracture but whether this is independent of osteoporosis is unclear.-
dc.description.abstractWe conducted a retrospective cross-sectional study of 1,702 female patients referred for dual-energy X-ray absorptiometry (DXA) scanning (Lunar IDXA) between September 2006 and April 2007. Estimated glomerular filtration rate (eGFR; ml/min/1.73 m(2)) by Modification of Diet in Renal Disease was calculated within 1 year (median interval 4 weeks) of the DXA scan. The independent association of self-reported fracture occurrence with eGFR category was assessed using multivariate logistic regression.-
dc.description.abstractMean age (SD) was 61.7 (10.8) years; mean eGFR (SD) was 68.8 (12.2). The percentages of subjects with an eGFR of 75-89, 60-74, 30-59 and <30 was 34, 45, 20 and 0.8%, respectively. Forty-seven percent had osteoporosis. Mean T scores for the above eGFR categories were -2.2, -2.3, -2.5 and -3.0, respectively (p trend <0.001). Osteoporosis was significantly associated with eGFR on univariate analysis but not following adjustment for age. The percentage of patients with a fracture (29%) and with multiple prior fractures (3.5%) was higher at lower eGFR (p < 0.001, χ(2) test). The adjusted odds ratios (95% confidence interval) of any prior fracture for eGFR 75-89, 60-74 and 30-59 were 1.0 (reference), 1.2 (0.9-1.6) and 1.4 (1.0-1.9), respectively, adjusting simultaneously for age, T score, risk factors and treatment for osteoporosis.-
dc.description.abstractModerate CKD is a significant independent predictor of fracture occurrence.-
dc.language.isoenen
dc.publisherKargeren
dc.subject.meshAbsorptiometry, Photon-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshBone Density-
dc.subject.meshChronic Disease-
dc.subject.meshCross-Sectional Studies-
dc.subject.meshFemale-
dc.subject.meshFractures, Bone-
dc.subject.meshFractures, Spontaneous-
dc.subject.meshGlomerular Filtration Rate-
dc.subject.meshHumans-
dc.subject.meshIreland-
dc.subject.meshKidney Diseases-
dc.subject.meshMiddle Aged-
dc.subject.meshMinerals-
dc.subject.meshOsteoporosis-
dc.subject.meshRetrospective Studies-
dc.subject.meshRisk-
dc.subject.meshYoung Adult-
dc.titleModerate chronic kidney disease in women is associated with fracture occurrence independently of osteoporosis.en
dc.typeArticleen
dc.contributor.departmentDepartment of Nephrology, Cork University Hospital, Cork, Ireland.en
dc.identifier.journalNephron. Clinical practiceen
dc.description.provinceMunster-

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