EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy.

Hdl Handle:
http://hdl.handle.net/10147/200037
Title:
EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy.
Authors:
Galvin, R; Bråthen, G; Ivashynka, A; Hillbom, M; Tanasescu, R; Leone, M A
Affiliation:
Department of Neurology, Cork University Hospital, Wilton, Cork, Ireland.
Citation:
EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy. 2010, 17 (12):1408-18 Eur. J. Neurol.
Journal:
European journal of neurology : the official journal of the European Federation of Neurological Societies
Issue Date:
Dec-2010
URI:
http://hdl.handle.net/10147/200037
DOI:
10.1111/j.1468-1331.2010.03153.x
PubMed ID:
20642790
Abstract:
Although Wernicke encephalopathy (WE) is a preventable and treatable disease it still often remains undiagnosed during life.; To create practical guidelines for diagnosis, management and prevention of the disease.; We searched MEDLINE, EMBASE, LILACS, Cochrane Library.; 1 The clinical diagnosis of WE should take into account the different presentations of clinical signs between alcoholics and non alcoholics (Recommendation Level C); although prevalence is higher in alcoholics, WE should be suspected in all clinical conditions which could lead to thiamine deficiency (good practice point - GPP). 2 The clinical diagnosis of WE in alcoholics requires two of the following four signs; (i) dietary deficiencies (ii) eye signs, (iii) cerebellar dysfunction, and (iv) either an altered mental state or mild memory impairment (Level B). 3 Total thiamine in blood sample should be measured immediately before its administration (GPP). 4 MRI should be used to support the diagnosis of acute WE both in alcoholics and non alcoholics (Level B). 5 Thiamine is indicated for the treatment of suspected or manifest WE. It should be given, before any carbohydrate, 200 mg thrice daily, preferably intravenously (Level C). 6 The overall safety of thiamine is very good (Level B). 7 After bariatric surgery we recommend follow-up of thiamine status for at least 6 months (Level B) and parenteral thiamine supplementation (GPP). 8 Parenteral thiamine should be given to all at-risk subjects admitted to the Emergency Room (GPP). 9 Patients dying from symptoms suggesting WE should have an autopsy (GPP).
Item Type:
Article
Language:
en
MeSH:
Diagnosis, Differential; Humans; Thiamine; Wernicke Encephalopathy
ISSN:
1468-1331

Full metadata record

DC FieldValue Language
dc.contributor.authorGalvin, Ren
dc.contributor.authorBråthen, Gen
dc.contributor.authorIvashynka, Aen
dc.contributor.authorHillbom, Men
dc.contributor.authorTanasescu, Ren
dc.contributor.authorLeone, M Aen
dc.date.accessioned2012-01-04T15:48:33Z-
dc.date.available2012-01-04T15:48:33Z-
dc.date.issued2010-12-
dc.identifier.citationEFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy. 2010, 17 (12):1408-18 Eur. J. Neurol.en
dc.identifier.issn1468-1331-
dc.identifier.pmid20642790-
dc.identifier.doi10.1111/j.1468-1331.2010.03153.x-
dc.identifier.urihttp://hdl.handle.net/10147/200037-
dc.description.abstractAlthough Wernicke encephalopathy (WE) is a preventable and treatable disease it still often remains undiagnosed during life.-
dc.description.abstractTo create practical guidelines for diagnosis, management and prevention of the disease.-
dc.description.abstractWe searched MEDLINE, EMBASE, LILACS, Cochrane Library.-
dc.description.abstract1 The clinical diagnosis of WE should take into account the different presentations of clinical signs between alcoholics and non alcoholics (Recommendation Level C); although prevalence is higher in alcoholics, WE should be suspected in all clinical conditions which could lead to thiamine deficiency (good practice point - GPP). 2 The clinical diagnosis of WE in alcoholics requires two of the following four signs; (i) dietary deficiencies (ii) eye signs, (iii) cerebellar dysfunction, and (iv) either an altered mental state or mild memory impairment (Level B). 3 Total thiamine in blood sample should be measured immediately before its administration (GPP). 4 MRI should be used to support the diagnosis of acute WE both in alcoholics and non alcoholics (Level B). 5 Thiamine is indicated for the treatment of suspected or manifest WE. It should be given, before any carbohydrate, 200 mg thrice daily, preferably intravenously (Level C). 6 The overall safety of thiamine is very good (Level B). 7 After bariatric surgery we recommend follow-up of thiamine status for at least 6 months (Level B) and parenteral thiamine supplementation (GPP). 8 Parenteral thiamine should be given to all at-risk subjects admitted to the Emergency Room (GPP). 9 Patients dying from symptoms suggesting WE should have an autopsy (GPP).-
dc.language.isoenen
dc.subject.meshDiagnosis, Differential-
dc.subject.meshHumans-
dc.subject.meshThiamine-
dc.subject.meshWernicke Encephalopathy-
dc.titleEFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy.en
dc.typeArticleen
dc.contributor.departmentDepartment of Neurology, Cork University Hospital, Wilton, Cork, Ireland.en
dc.identifier.journalEuropean journal of neurology : the official journal of the European Federation of Neurological Societiesen
dc.description.provinceMunster-

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