Maternal separation as a model of brain-gut axis dysfunction.

Hdl Handle:
http://hdl.handle.net/10147/198851
Title:
Maternal separation as a model of brain-gut axis dysfunction.
Authors:
O'Mahony, Siobhain M; Hyland, Niall P; Dinan, Timothy G; Cryan, John F
Affiliation:
Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland. somahony@ucc.ie
Citation:
Maternal separation as a model of brain-gut axis dysfunction. 2011, 214 (1):71-88 Psychopharmacology (Berl.)
Publisher:
Springer
Journal:
Psychopharmacology
Issue Date:
Mar-2011
URI:
http://hdl.handle.net/10147/198851
DOI:
10.1007/s00213-010-2010-9
PubMed ID:
20886335
Abstract:
Early life stress has been implicated in many psychiatric disorders ranging from depression to anxiety. Maternal separation in rodents is a well-studied model of early life stress. However, stress during this critical period also induces alterations in many systems throughout the body. Thus, a variety of other disorders that are associated with adverse early life events are often comorbid with psychiatric illnesses, suggesting a common underlying aetiology. Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that is thought to involve a dysfunctional interaction between the brain and the gut. Essential aspects of the brain-gut axis include spinal pathways, the hypothalamic pituitary adrenal axis, the immune system, as well as the enteric microbiota. Accumulating evidence suggest that stress, especially in early life, is a predisposing factor to IBS.; The objective of this review was to assess and compile the most relevant data on early life stress and alterations at all levels of the brain gut axis.; In this review, we describe the components of the brain-gut axis individually and how they are altered by maternal separation. The separated phenotype is characterised by alterations of the intestinal barrier function, altered balance in enteric microflora, exaggerated stress response and visceral hypersensitivity, which are all evident in IBS.; Thus, maternally separated animals are an excellent model of brain-gut axis dysfunction for the study of disorders such as IBS and for the development of novel therapeutic interventions.
Item Type:
Article
Language:
en
Description:
RATIONALE: Early life stress has been implicated in many psychiatric disorders ranging from depression to anxiety. Maternal separation in rodents is a well-studied model of early life stress. However, stress during this critical period also induces alterations in many systems throughout the body. Thus, a variety of other disorders that are associated with adverse early life events are often comorbid with psychiatric illnesses, suggesting a common underlying aetiology. Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that is thought to involve a dysfunctional interaction between the brain and the gut. Essential aspects of the brain-gut axis include spinal pathways, the hypothalamic pituitary adrenal axis, the immune system, as well as the enteric microbiota. Accumulating evidence suggest that stress, especially in early life, is a predisposing factor to IBS. OBJECTIVE: The objective of this review was to assess and compile the most relevant data on early life stress and alterations at all levels of the brain gut axis. RESULTS: In this review, we describe the components of the brain-gut axis individually and how they are altered by maternal separation. The separated phenotype is characterised by alterations of the intestinal barrier function, altered balance in enteric microflora, exaggerated stress response and visceral hypersensitivity, which are all evident in IBS. CONCLUSION: Thus, maternally separated animals are an excellent model of brain-gut axis dysfunction for the study of disorders such as IBS and for the development of novel therapeutic interventions.
MeSH:
Animals; Brain; Disease Models, Animal; Gastrointestinal Tract; Humans; Irritable Bowel Syndrome; Life Change Events; Maternal Deprivation; Rodentia; Stress, Psychological
ISSN:
1432-2072

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Mahony, Siobhain Men
dc.contributor.authorHyland, Niall Pen
dc.contributor.authorDinan, Timothy Gen
dc.contributor.authorCryan, John Fen
dc.date.accessioned2011-12-23T10:38:41Z-
dc.date.available2011-12-23T10:38:41Z-
dc.date.issued2011-03-
dc.identifier.citationMaternal separation as a model of brain-gut axis dysfunction. 2011, 214 (1):71-88 Psychopharmacology (Berl.)en
dc.identifier.issn1432-2072-
dc.identifier.pmid20886335-
dc.identifier.doi10.1007/s00213-010-2010-9-
dc.identifier.urihttp://hdl.handle.net/10147/198851-
dc.descriptionRATIONALE: Early life stress has been implicated in many psychiatric disorders ranging from depression to anxiety. Maternal separation in rodents is a well-studied model of early life stress. However, stress during this critical period also induces alterations in many systems throughout the body. Thus, a variety of other disorders that are associated with adverse early life events are often comorbid with psychiatric illnesses, suggesting a common underlying aetiology. Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that is thought to involve a dysfunctional interaction between the brain and the gut. Essential aspects of the brain-gut axis include spinal pathways, the hypothalamic pituitary adrenal axis, the immune system, as well as the enteric microbiota. Accumulating evidence suggest that stress, especially in early life, is a predisposing factor to IBS. OBJECTIVE: The objective of this review was to assess and compile the most relevant data on early life stress and alterations at all levels of the brain gut axis. RESULTS: In this review, we describe the components of the brain-gut axis individually and how they are altered by maternal separation. The separated phenotype is characterised by alterations of the intestinal barrier function, altered balance in enteric microflora, exaggerated stress response and visceral hypersensitivity, which are all evident in IBS. CONCLUSION: Thus, maternally separated animals are an excellent model of brain-gut axis dysfunction for the study of disorders such as IBS and for the development of novel therapeutic interventions.en
dc.description.abstractEarly life stress has been implicated in many psychiatric disorders ranging from depression to anxiety. Maternal separation in rodents is a well-studied model of early life stress. However, stress during this critical period also induces alterations in many systems throughout the body. Thus, a variety of other disorders that are associated with adverse early life events are often comorbid with psychiatric illnesses, suggesting a common underlying aetiology. Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that is thought to involve a dysfunctional interaction between the brain and the gut. Essential aspects of the brain-gut axis include spinal pathways, the hypothalamic pituitary adrenal axis, the immune system, as well as the enteric microbiota. Accumulating evidence suggest that stress, especially in early life, is a predisposing factor to IBS.-
dc.description.abstractThe objective of this review was to assess and compile the most relevant data on early life stress and alterations at all levels of the brain gut axis.-
dc.description.abstractIn this review, we describe the components of the brain-gut axis individually and how they are altered by maternal separation. The separated phenotype is characterised by alterations of the intestinal barrier function, altered balance in enteric microflora, exaggerated stress response and visceral hypersensitivity, which are all evident in IBS.-
dc.description.abstractThus, maternally separated animals are an excellent model of brain-gut axis dysfunction for the study of disorders such as IBS and for the development of novel therapeutic interventions.-
dc.language.isoenen
dc.publisherSpringeren
dc.subject.meshAnimals-
dc.subject.meshBrain-
dc.subject.meshDisease Models, Animal-
dc.subject.meshGastrointestinal Tract-
dc.subject.meshHumans-
dc.subject.meshIrritable Bowel Syndrome-
dc.subject.meshLife Change Events-
dc.subject.meshMaternal Deprivation-
dc.subject.meshRodentia-
dc.subject.meshStress, Psychological-
dc.titleMaternal separation as a model of brain-gut axis dysfunction.en
dc.typeArticleen
dc.contributor.departmentAlimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland. somahony@ucc.ieen
dc.identifier.journalPsychopharmacologyen
dc.description.provinceMunster-

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