Generalized subcutaneous edema as a rare manifestation of dermatomyositis: clinical lesson from a rare feature.

Hdl Handle:
http://hdl.handle.net/10147/198774
Title:
Generalized subcutaneous edema as a rare manifestation of dermatomyositis: clinical lesson from a rare feature.
Authors:
Haroon, Muhammad; Eltahir, Ahmed; Harney, Sinead
Affiliation:
Department of Rheumatology, Sports and Exercise Medicine, Cork University Hospital, Cork, Ireland. Mharoon301@hotmail.com
Citation:
Generalized subcutaneous edema as a rare manifestation of dermatomyositis: clinical lesson from a rare feature. 2011, 17 (3):135-7 J Clin Rheumatol
Journal:
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
Issue Date:
Apr-2011
URI:
http://hdl.handle.net/10147/198774
DOI:
10.1097/RHU.0b013e318214f1a9
PubMed ID:
21441819
Abstract:
Generalized subcutaneous edema is a very rare manifestation of inflammatory myopathies. A 61-year-old woman presented with classic signs and symptoms of dermatomyositis. She was also noted to have generalized edema that was so florid that an alternative diagnosis was considered. Her disease was resistant to corticosteroids, azathioprine, and mycophenolate mofetil. Intravenous administration of immunoglobulins was started because of marked worsening of her disease-muscle weakness, generalized anasarca, and involvement of her bulbar muscles. This led to dramatic resolution of her subcutaneous edema and significant improvement of her skin and muscle disease. As the initial screen for malignancy was negative, a positron emission tomography-computed tomography scan was requested, which interestingly showed a metabolically active cervical tumor. Anasarca is an unusual manifestation of dermatomyositis. In treatment-refractory cases, it seems reasonable to consider positron emission tomography scan in excluding underlying malignant disease.
Item Type:
Article
Language:
en
Description:
Generalized subcutaneous edema is a very rare manifestation of inflammatory myopathies. A 61-year-old woman presented with classic signs and symptoms of dermatomyositis. She was also noted to have generalized edema that was so florid that an alternative diagnosis was considered. Her disease was resistant to corticosteroids, azathioprine, and mycophenolate mofetil. Intravenous administration of immunoglobulins was started because of marked worsening of her disease-muscle weakness, generalized anasarca, and involvement of her bulbar muscles. This led to dramatic resolution of her subcutaneous edema and significant improvement of her skin and muscle disease. As the initial screen for malignancy was negative, a positron emission tomography-computed tomography scan was requested, which interestingly showed a metabolically active cervical tumor. Anasarca is an unusual manifestation of dermatomyositis. In treatment-refractory cases, it seems reasonable to consider positron emission tomography scan in excluding underlying malignant disease.
MeSH:
Dermatomyositis; Edema; Female; Humans; Immunoglobulins, Intravenous; Lung Neoplasms; Middle Aged; Neoplasms, Squamous Cell; Radiotherapy; Tomography, Emission-Computed, Single-Photon; Treatment Outcome; Uterine Cervical Neoplasms
ISSN:
1536-7355

Full metadata record

DC FieldValue Language
dc.contributor.authorHaroon, Muhammaden
dc.contributor.authorEltahir, Ahmeden
dc.contributor.authorHarney, Sineaden
dc.date.accessioned2011-12-22T16:00:24Z-
dc.date.available2011-12-22T16:00:24Z-
dc.date.issued2011-04-
dc.identifier.citationGeneralized subcutaneous edema as a rare manifestation of dermatomyositis: clinical lesson from a rare feature. 2011, 17 (3):135-7 J Clin Rheumatolen
dc.identifier.issn1536-7355-
dc.identifier.pmid21441819-
dc.identifier.doi10.1097/RHU.0b013e318214f1a9-
dc.identifier.urihttp://hdl.handle.net/10147/198774-
dc.descriptionGeneralized subcutaneous edema is a very rare manifestation of inflammatory myopathies. A 61-year-old woman presented with classic signs and symptoms of dermatomyositis. She was also noted to have generalized edema that was so florid that an alternative diagnosis was considered. Her disease was resistant to corticosteroids, azathioprine, and mycophenolate mofetil. Intravenous administration of immunoglobulins was started because of marked worsening of her disease-muscle weakness, generalized anasarca, and involvement of her bulbar muscles. This led to dramatic resolution of her subcutaneous edema and significant improvement of her skin and muscle disease. As the initial screen for malignancy was negative, a positron emission tomography-computed tomography scan was requested, which interestingly showed a metabolically active cervical tumor. Anasarca is an unusual manifestation of dermatomyositis. In treatment-refractory cases, it seems reasonable to consider positron emission tomography scan in excluding underlying malignant disease.en
dc.description.abstractGeneralized subcutaneous edema is a very rare manifestation of inflammatory myopathies. A 61-year-old woman presented with classic signs and symptoms of dermatomyositis. She was also noted to have generalized edema that was so florid that an alternative diagnosis was considered. Her disease was resistant to corticosteroids, azathioprine, and mycophenolate mofetil. Intravenous administration of immunoglobulins was started because of marked worsening of her disease-muscle weakness, generalized anasarca, and involvement of her bulbar muscles. This led to dramatic resolution of her subcutaneous edema and significant improvement of her skin and muscle disease. As the initial screen for malignancy was negative, a positron emission tomography-computed tomography scan was requested, which interestingly showed a metabolically active cervical tumor. Anasarca is an unusual manifestation of dermatomyositis. In treatment-refractory cases, it seems reasonable to consider positron emission tomography scan in excluding underlying malignant disease.-
dc.language.isoenen
dc.subject.meshDermatomyositis-
dc.subject.meshEdema-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunoglobulins, Intravenous-
dc.subject.meshLung Neoplasms-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasms, Squamous Cell-
dc.subject.meshRadiotherapy-
dc.subject.meshTomography, Emission-Computed, Single-Photon-
dc.subject.meshTreatment Outcome-
dc.subject.meshUterine Cervical Neoplasms-
dc.titleGeneralized subcutaneous edema as a rare manifestation of dermatomyositis: clinical lesson from a rare feature.en
dc.typeArticleen
dc.contributor.departmentDepartment of Rheumatology, Sports and Exercise Medicine, Cork University Hospital, Cork, Ireland. Mharoon301@hotmail.comen
dc.identifier.journalJournal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseasesen
dc.description.provinceMunster-

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.