Initial experiences with isolated limb perfusion for unresectable melanoma of the limb.

Hdl Handle:
http://hdl.handle.net/10147/198751
Title:
Initial experiences with isolated limb perfusion for unresectable melanoma of the limb.
Authors:
Romics, L; Dy, E A; Coffey, J C; Herlihy, D; Aftab, F; Chaudhry, M Z; Fogarty, K; O'Donnell, J A; Redmond, H P
Affiliation:
Department of Surgery, Cork University Hospital, Cork, Ireland. Laszlo.Romics@umassmed.edu
Citation:
Initial experiences with isolated limb perfusion for unresectable melanoma of the limb. 2011, 180 (2):517-20 Ir J Med Sci
Journal:
Irish journal of medical science
Issue Date:
Jun-2011
URI:
http://hdl.handle.net/10147/198751
DOI:
10.1007/s11845-010-0664-2
PubMed ID:
21287291
Abstract:
Our initial results with isolated limb perfusion (ILP) using melphalan ± TNF alpha in patients with unresectable melanoma of the limb were analyzed.; 15 ILPs were performed between 2001 and 2006. Indications for ILP were stage III or IV metastatic melanoma. Complete and partial response rates, time to local and systemic tumour progression rates, disease free and overall survival rates were retrospectively analyzed.; Overall response rate was 93%, with a 67% complete response and a 26% partial response rate. In eight cases grade II, while in six cases grade III local toxicity was detected. However, one mortality was detected in the early postoperative phase due to a grade V complication. With a mean follow-up period of 2.7 years, eight patients had local progression and in four of those, systemic progression was detected.; ILP was generally well tolerated and limb salvage was achieved in all cases.
Item Type:
Article
Language:
en
Description:
AIMS: Our initial results with isolated limb perfusion (ILP) using melphalan ± TNF alpha in patients with unresectable melanoma of the limb were analyzed. METHODS: 15 ILPs were performed between 2001 and 2006. Indications for ILP were stage III or IV metastatic melanoma. Complete and partial response rates, time to local and systemic tumour progression rates, disease free and overall survival rates were retrospectively analyzed. RESULTS: Overall response rate was 93%, with a 67% complete response and a 26% partial response rate. In eight cases grade II, while in six cases grade III local toxicity was detected. However, one mortality was detected in the early postoperative phase due to a grade V complication. With a mean follow-up period of 2.7 years, eight patients had local progression and in four of those, systemic progression was detected. CONCLUSIONS: ILP was generally well tolerated and limb salvage was achieved in all cases.
MeSH:
Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Female; Humans; Lower Extremity; Male; Melanoma; Melphalan; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Skin Neoplasms; Treatment Outcome; Tumor Necrosis Factor-alpha; Upper Extremity
ISSN:
1863-4362

Full metadata record

DC FieldValue Language
dc.contributor.authorRomics, Len
dc.contributor.authorDy, E Aen
dc.contributor.authorCoffey, J Cen
dc.contributor.authorHerlihy, Den
dc.contributor.authorAftab, Fen
dc.contributor.authorChaudhry, M Zen
dc.contributor.authorFogarty, Ken
dc.contributor.authorO'Donnell, J Aen
dc.contributor.authorRedmond, H Pen
dc.date.accessioned2011-12-22T15:27:17Z-
dc.date.available2011-12-22T15:27:17Z-
dc.date.issued2011-06-
dc.identifier.citationInitial experiences with isolated limb perfusion for unresectable melanoma of the limb. 2011, 180 (2):517-20 Ir J Med Scien
dc.identifier.issn1863-4362-
dc.identifier.pmid21287291-
dc.identifier.doi10.1007/s11845-010-0664-2-
dc.identifier.urihttp://hdl.handle.net/10147/198751-
dc.descriptionAIMS: Our initial results with isolated limb perfusion (ILP) using melphalan ± TNF alpha in patients with unresectable melanoma of the limb were analyzed. METHODS: 15 ILPs were performed between 2001 and 2006. Indications for ILP were stage III or IV metastatic melanoma. Complete and partial response rates, time to local and systemic tumour progression rates, disease free and overall survival rates were retrospectively analyzed. RESULTS: Overall response rate was 93%, with a 67% complete response and a 26% partial response rate. In eight cases grade II, while in six cases grade III local toxicity was detected. However, one mortality was detected in the early postoperative phase due to a grade V complication. With a mean follow-up period of 2.7 years, eight patients had local progression and in four of those, systemic progression was detected. CONCLUSIONS: ILP was generally well tolerated and limb salvage was achieved in all cases.en
dc.description.abstractOur initial results with isolated limb perfusion (ILP) using melphalan ± TNF alpha in patients with unresectable melanoma of the limb were analyzed.-
dc.description.abstract15 ILPs were performed between 2001 and 2006. Indications for ILP were stage III or IV metastatic melanoma. Complete and partial response rates, time to local and systemic tumour progression rates, disease free and overall survival rates were retrospectively analyzed.-
dc.description.abstractOverall response rate was 93%, with a 67% complete response and a 26% partial response rate. In eight cases grade II, while in six cases grade III local toxicity was detected. However, one mortality was detected in the early postoperative phase due to a grade V complication. With a mean follow-up period of 2.7 years, eight patients had local progression and in four of those, systemic progression was detected.-
dc.description.abstractILP was generally well tolerated and limb salvage was achieved in all cases.-
dc.language.isoenen
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols-
dc.subject.meshChemotherapy, Cancer, Regional Perfusion-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLower Extremity-
dc.subject.meshMale-
dc.subject.meshMelanoma-
dc.subject.meshMelphalan-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Recurrence, Local-
dc.subject.meshRetrospective Studies-
dc.subject.meshSkin Neoplasms-
dc.subject.meshTreatment Outcome-
dc.subject.meshTumor Necrosis Factor-alpha-
dc.subject.meshUpper Extremity-
dc.titleInitial experiences with isolated limb perfusion for unresectable melanoma of the limb.en
dc.typeArticleen
dc.contributor.departmentDepartment of Surgery, Cork University Hospital, Cork, Ireland. Laszlo.Romics@umassmed.eduen
dc.identifier.journalIrish journal of medical scienceen
dc.description.provinceMunster-

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.