Intra subject variation and correlation of motor potentials evoked by transcranial magnetic stimulation.

Hdl Handle:
http://hdl.handle.net/10147/198749
Title:
Intra subject variation and correlation of motor potentials evoked by transcranial magnetic stimulation.
Authors:
Roy Choudhury, K; Boyle, L; Burke, M; Lombard, W; Ryan, S; McNamara, B
Affiliation:
Statistics Department, University College Cork, Cork, Ireland. kingshuk@ucc.ie
Citation:
Intra subject variation and correlation of motor potentials evoked by transcranial magnetic stimulation. 2011, 180 (4):873-80 Ir J Med Sci
Journal:
Irish journal of medical science
Issue Date:
Dec-2011
URI:
http://hdl.handle.net/10147/198749
DOI:
10.1007/s11845-011-0722-4
PubMed ID:
21660652
Abstract:
Characterising intra and inter-subject variability of motor-evoked potential (MEP) measurements from transcranial magnetic stimulation (TMS) is key to its development as a diagnostic tool.; We performed three experiments to elucidate MEP variability within subjects: (i) repeated measurements at different levels of stimulation and muscle activation, (ii) simultaneous measurements at pairs of ipsilateral and contralateral muscles, (iii) simultaneous measurements of contralateral muscles when one is activated.; Cube root transformation of MEP data produces approximately constant coefficient of variation with Gaussian distribution and no significant autocorrelation between repeat measurements. After adjustment of intersubject variability, correlation between simultaneous muscle pairs was insignificant (p = 0.36). Highly significant effects were observed due to increase in intensity of stimulation: (0.07, 0.23) mV, p < 0.0001, muscle type: (p < 0.009) and activation of ipsilateral muscle: (0.10, 0.49) mV, p < 0.0001.; Corticospinal effect is dominated by intersubject variability in simultaneous measurements on normal population.
Item Type:
Article
Language:
en
Description:
BACKGROUND: Characterising intra and inter-subject variability of motor-evoked potential (MEP) measurements from transcranial magnetic stimulation (TMS) is key to its development as a diagnostic tool. METHODS: We performed three experiments to elucidate MEP variability within subjects: (i) repeated measurements at different levels of stimulation and muscle activation, (ii) simultaneous measurements at pairs of ipsilateral and contralateral muscles, (iii) simultaneous measurements of contralateral muscles when one is activated. RESULTS: Cube root transformation of MEP data produces approximately constant coefficient of variation with Gaussian distribution and no significant autocorrelation between repeat measurements. After adjustment of intersubject variability, correlation between simultaneous muscle pairs was insignificant (p = 0.36). Highly significant effects were observed due to increase in intensity of stimulation: (0.07, 0.23) mV, p < 0.0001, muscle type: (p < 0.009) and activation of ipsilateral muscle: (0.10, 0.49) mV, p < 0.0001. CONCLUSION: Corticospinal effect is dominated by intersubject variability in simultaneous measurements on normal population.
ISSN:
1863-4362

Full metadata record

DC FieldValue Language
dc.contributor.authorRoy Choudhury, Ken
dc.contributor.authorBoyle, Len
dc.contributor.authorBurke, Men
dc.contributor.authorLombard, Wen
dc.contributor.authorRyan, Sen
dc.contributor.authorMcNamara, Ben
dc.date.accessioned2011-12-22T15:22:09Z-
dc.date.available2011-12-22T15:22:09Z-
dc.date.issued2011-12-
dc.identifier.citationIntra subject variation and correlation of motor potentials evoked by transcranial magnetic stimulation. 2011, 180 (4):873-80 Ir J Med Scien
dc.identifier.issn1863-4362-
dc.identifier.pmid21660652-
dc.identifier.doi10.1007/s11845-011-0722-4-
dc.identifier.urihttp://hdl.handle.net/10147/198749-
dc.descriptionBACKGROUND: Characterising intra and inter-subject variability of motor-evoked potential (MEP) measurements from transcranial magnetic stimulation (TMS) is key to its development as a diagnostic tool. METHODS: We performed three experiments to elucidate MEP variability within subjects: (i) repeated measurements at different levels of stimulation and muscle activation, (ii) simultaneous measurements at pairs of ipsilateral and contralateral muscles, (iii) simultaneous measurements of contralateral muscles when one is activated. RESULTS: Cube root transformation of MEP data produces approximately constant coefficient of variation with Gaussian distribution and no significant autocorrelation between repeat measurements. After adjustment of intersubject variability, correlation between simultaneous muscle pairs was insignificant (p = 0.36). Highly significant effects were observed due to increase in intensity of stimulation: (0.07, 0.23) mV, p < 0.0001, muscle type: (p < 0.009) and activation of ipsilateral muscle: (0.10, 0.49) mV, p < 0.0001. CONCLUSION: Corticospinal effect is dominated by intersubject variability in simultaneous measurements on normal population.en
dc.description.abstractCharacterising intra and inter-subject variability of motor-evoked potential (MEP) measurements from transcranial magnetic stimulation (TMS) is key to its development as a diagnostic tool.-
dc.description.abstractWe performed three experiments to elucidate MEP variability within subjects: (i) repeated measurements at different levels of stimulation and muscle activation, (ii) simultaneous measurements at pairs of ipsilateral and contralateral muscles, (iii) simultaneous measurements of contralateral muscles when one is activated.-
dc.description.abstractCube root transformation of MEP data produces approximately constant coefficient of variation with Gaussian distribution and no significant autocorrelation between repeat measurements. After adjustment of intersubject variability, correlation between simultaneous muscle pairs was insignificant (p = 0.36). Highly significant effects were observed due to increase in intensity of stimulation: (0.07, 0.23) mV, p < 0.0001, muscle type: (p < 0.009) and activation of ipsilateral muscle: (0.10, 0.49) mV, p < 0.0001.-
dc.description.abstractCorticospinal effect is dominated by intersubject variability in simultaneous measurements on normal population.-
dc.language.isoenen
dc.titleIntra subject variation and correlation of motor potentials evoked by transcranial magnetic stimulation.en
dc.typeArticleen
dc.contributor.departmentStatistics Department, University College Cork, Cork, Ireland. kingshuk@ucc.ieen
dc.identifier.journalIrish journal of medical scienceen
dc.description.provinceMunster-

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