Prevalence of potentially inappropriate prescribing in an acutely ill population of older patients admitted to six European hospitals.

Hdl Handle:
http://hdl.handle.net/10147/198742
Title:
Prevalence of potentially inappropriate prescribing in an acutely ill population of older patients admitted to six European hospitals.
Authors:
Gallagher, Paul; Lang, Pierre Olivier; Cherubini, Antonio; Topinková, Eva; Cruz-Jentoft, Alfonso; Montero Errasquín, Beatriz; Mádlová, Pavla; Gasperini, Beatrice; Baeyens, Hilde; Baeyens, Jean-Pierre; Michel, Jean-Pierre; O'Mahony, Denis
Affiliation:
Department of Geriatric Medicine, Cork University Hospital, Wilton, Cork, Ireland. pfgallagher77@eircom.net
Citation:
Prevalence of potentially inappropriate prescribing in an acutely ill population of older patients admitted to six European hospitals. 2011, 67 (11):1175-88 Eur. J. Clin. Pharmacol.
Publisher:
Springer
Journal:
European journal of clinical pharmacology
Issue Date:
Nov-2011
URI:
http://hdl.handle.net/10147/198742
DOI:
10.1007/s00228-011-1061-0
PubMed ID:
21584788
Abstract:
Potentially inappropriate prescribing is common in older people presenting to hospital with acute illness in Ireland. The aim of this study was to determine if this phenomenon is unique to Ireland or whether it is a more widespread problem in hospitals across Europe.; Prospective data were collected from 900 consecutive older patients admitted to six university teaching hospitals (150 patients per centre) in Geneva (Switzerland), Madrid (Spain), Oostende (Belgium), Perugia (Italy), Prague (Czech Republic) and Cork (Ireland). Age, gender, comorbidity, cognitive status, prescription medicines taken before admission and baseline haematological, biochemical and electrocardiographic data were recorded. STOPP and Beers' criteria were applied to detect potentially inappropriate medicines (PIMs). START criteria were applied to detect potentially inappropriate prescribing omissions (PPOs).; The overall PIM prevalence rate was 51.3% using STOPP criteria, varying from 34.7% in Prague to 77.3% in Geneva, and 30.4% using Beer's criteria, varying from 22.7% in Prague to 43.3% in Geneva. Using START criteria, the overall PPO prevalence rate was 59.4%, ranging from 51.3% in Cork to 72.7% in Perugia. Polypharmacy predicted the presence of PIMs using STOPP criteria [with >10 medications: odds ratio (OR)  7.22, 95% confidence interval (CI) 4.30-12.12, p < 0.001] and Beers' criteria (with >10 medications: OR 4.87, 95% CI 3.00-7.90, p < 0.001). Increasing co-morbidity (Charlson Index ≥2) and age ≥85 years significantly predicted PPOs.; Potentially inappropriate drug prescribing and the omission of beneficial drugs are highly prevalent in acutely ill hospitalized older people in six European centres.
Item Type:
Article
Language:
en
Description:
PURPOSE: Potentially inappropriate prescribing is common in older people presenting to hospital with acute illness in Ireland. The aim of this study was to determine if this phenomenon is unique to Ireland or whether it is a more widespread problem in hospitals across Europe. METHODS: Prospective data were collected from 900 consecutive older patients admitted to six university teaching hospitals (150 patients per centre) in Geneva (Switzerland), Madrid (Spain), Oostende (Belgium), Perugia (Italy), Prague (Czech Republic) and Cork (Ireland). Age, gender, comorbidity, cognitive status, prescription medicines taken before admission and baseline haematological, biochemical and electrocardiographic data were recorded. STOPP and Beers' criteria were applied to detect potentially inappropriate medicines (PIMs). START criteria were applied to detect potentially inappropriate prescribing omissions (PPOs). RESULTS: The overall PIM prevalence rate was 51.3% using STOPP criteria, varying from 34.7% in Prague to 77.3% in Geneva, and 30.4% using Beer's criteria, varying from 22.7% in Prague to 43.3% in Geneva. Using START criteria, the overall PPO prevalence rate was 59.4%, ranging from 51.3% in Cork to 72.7% in Perugia. Polypharmacy predicted the presence of PIMs using STOPP criteria [with >10 medications: odds ratio (OR)  7.22, 95% confidence interval (CI) 4.30-12.12, p < 0.001] and Beers' criteria (with >10 medications: OR 4.87, 95% CI 3.00-7.90, p < 0.001). Increasing co-morbidity (Charlson Index ≥2) and age ≥85 years significantly predicted PPOs. CONCLUSION: Potentially inappropriate drug prescribing and the omission of beneficial drugs are highly prevalent in acutely ill hospitalized older people in six European centres.
ISSN:
1432-1041

Full metadata record

DC FieldValue Language
dc.contributor.authorGallagher, Paulen
dc.contributor.authorLang, Pierre Olivieren
dc.contributor.authorCherubini, Antonioen
dc.contributor.authorTopinková, Evaen
dc.contributor.authorCruz-Jentoft, Alfonsoen
dc.contributor.authorMontero Errasquín, Beatrizen
dc.contributor.authorMádlová, Pavlaen
dc.contributor.authorGasperini, Beatriceen
dc.contributor.authorBaeyens, Hildeen
dc.contributor.authorBaeyens, Jean-Pierreen
dc.contributor.authorMichel, Jean-Pierreen
dc.contributor.authorO'Mahony, Denisen
dc.date.accessioned2011-12-22T15:36:33Z-
dc.date.available2011-12-22T15:36:33Z-
dc.date.issued2011-11-
dc.identifier.citationPrevalence of potentially inappropriate prescribing in an acutely ill population of older patients admitted to six European hospitals. 2011, 67 (11):1175-88 Eur. J. Clin. Pharmacol.en
dc.identifier.issn1432-1041-
dc.identifier.pmid21584788-
dc.identifier.doi10.1007/s00228-011-1061-0-
dc.identifier.urihttp://hdl.handle.net/10147/198742-
dc.descriptionPURPOSE: Potentially inappropriate prescribing is common in older people presenting to hospital with acute illness in Ireland. The aim of this study was to determine if this phenomenon is unique to Ireland or whether it is a more widespread problem in hospitals across Europe. METHODS: Prospective data were collected from 900 consecutive older patients admitted to six university teaching hospitals (150 patients per centre) in Geneva (Switzerland), Madrid (Spain), Oostende (Belgium), Perugia (Italy), Prague (Czech Republic) and Cork (Ireland). Age, gender, comorbidity, cognitive status, prescription medicines taken before admission and baseline haematological, biochemical and electrocardiographic data were recorded. STOPP and Beers' criteria were applied to detect potentially inappropriate medicines (PIMs). START criteria were applied to detect potentially inappropriate prescribing omissions (PPOs). RESULTS: The overall PIM prevalence rate was 51.3% using STOPP criteria, varying from 34.7% in Prague to 77.3% in Geneva, and 30.4% using Beer's criteria, varying from 22.7% in Prague to 43.3% in Geneva. Using START criteria, the overall PPO prevalence rate was 59.4%, ranging from 51.3% in Cork to 72.7% in Perugia. Polypharmacy predicted the presence of PIMs using STOPP criteria [with >10 medications: odds ratio (OR)  7.22, 95% confidence interval (CI) 4.30-12.12, p < 0.001] and Beers' criteria (with >10 medications: OR 4.87, 95% CI 3.00-7.90, p < 0.001). Increasing co-morbidity (Charlson Index ≥2) and age ≥85 years significantly predicted PPOs. CONCLUSION: Potentially inappropriate drug prescribing and the omission of beneficial drugs are highly prevalent in acutely ill hospitalized older people in six European centres.en
dc.description.abstractPotentially inappropriate prescribing is common in older people presenting to hospital with acute illness in Ireland. The aim of this study was to determine if this phenomenon is unique to Ireland or whether it is a more widespread problem in hospitals across Europe.-
dc.description.abstractProspective data were collected from 900 consecutive older patients admitted to six university teaching hospitals (150 patients per centre) in Geneva (Switzerland), Madrid (Spain), Oostende (Belgium), Perugia (Italy), Prague (Czech Republic) and Cork (Ireland). Age, gender, comorbidity, cognitive status, prescription medicines taken before admission and baseline haematological, biochemical and electrocardiographic data were recorded. STOPP and Beers' criteria were applied to detect potentially inappropriate medicines (PIMs). START criteria were applied to detect potentially inappropriate prescribing omissions (PPOs).-
dc.description.abstractThe overall PIM prevalence rate was 51.3% using STOPP criteria, varying from 34.7% in Prague to 77.3% in Geneva, and 30.4% using Beer's criteria, varying from 22.7% in Prague to 43.3% in Geneva. Using START criteria, the overall PPO prevalence rate was 59.4%, ranging from 51.3% in Cork to 72.7% in Perugia. Polypharmacy predicted the presence of PIMs using STOPP criteria [with >10 medications: odds ratio (OR)  7.22, 95% confidence interval (CI) 4.30-12.12, p < 0.001] and Beers' criteria (with >10 medications: OR 4.87, 95% CI 3.00-7.90, p < 0.001). Increasing co-morbidity (Charlson Index ≥2) and age ≥85 years significantly predicted PPOs.-
dc.description.abstractPotentially inappropriate drug prescribing and the omission of beneficial drugs are highly prevalent in acutely ill hospitalized older people in six European centres.-
dc.language.isoenen
dc.publisherSpringeren
dc.titlePrevalence of potentially inappropriate prescribing in an acutely ill population of older patients admitted to six European hospitals.en
dc.typeArticleen
dc.contributor.departmentDepartment of Geriatric Medicine, Cork University Hospital, Wilton, Cork, Ireland. pfgallagher77@eircom.neten
dc.identifier.journalEuropean journal of clinical pharmacologyen
dc.description.provinceMunster-
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