Potentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patients.

Hdl Handle:
http://hdl.handle.net/10147/198728
Title:
Potentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patients.
Authors:
Hamilton, Hilary; Gallagher, Paul; Ryan, Cristin; Byrne, Stephen; O'Mahony, Denis
Affiliation:
Department of Medicine, School of Medicine, University College Cork, Ireland.
Citation:
Potentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patients. 2011, 171 (11):1013-9 Arch. Intern. Med.
Journal:
Archives of internal medicine
Issue Date:
13-Jun-2011
URI:
http://hdl.handle.net/10147/198728
DOI:
10.1001/archinternmed.2011.215
PubMed ID:
21670370
Abstract:
Previous studies have not demonstrated a consistent association between potentially inappropriate medicines (PIMs) in older patients as defined by Beers criteria and avoidable adverse drug events (ADEs). This study aimed to assess whether PIMs defined by new STOPP (Screening Tool of Older Persons' potentially inappropriate Prescriptions) criteria are significantly associated with ADEs in older people with acute illness.; We prospectively studied 600 consecutive patients 65 years or older who were admitted with acute illness to a university teaching hospital over a 4-month interval. Potentially inappropriate medicines were defined by both Beers and STOPP criteria. Adverse drug events were defined by World Health Organization-Uppsala Monitoring Centre criteria and verified by a local expert consensus panel, which also assessed whether ADEs were causal or contributory to current hospitalization. Hallas criteria defined ADE avoidability. We compared the proportions of patients taking Beers criteria PIMs and STOPP criteria PIMs with avoidable ADEs that were causal or contributory to admission.; A total of 329 ADEs were detected in 158 of 600 patients (26.3%); 219 of 329 ADEs (66.6%) were considered causal or contributory to admission. Of the 219 ADEs, 151 (68.9%) considered causal or contributory to admission were avoidable or potentially avoidable. After adjusting for age, sex, comorbidity, dementia, baseline activities of daily living function, and number of medications, the likelihood of a serious avoidable ADE increased significantly when STOPP PIMs were prescribed (odds ratio, 1.847; 95% confidence interval [CI], 1.506-2.264; P < .001); prescription of Beers criteria PIMs did not significantly increase ADE risk (odds ratio, 1.276; 95% CI, 0.945-1.722; P = .11).; STOPP criteria PIMs, unlike Beers criteria PIMs, are significantly associated with avoidable ADEs in older people that cause or contribute to urgent hospitalization.
Item Type:
Article
Language:
en
Description:
BACKGROUND: Previous studies have not demonstrated a consistent association between potentially inappropriate medicines (PIMs) in older patients as defined by Beers criteria and avoidable adverse drug events (ADEs). This study aimed to assess whether PIMs defined by new STOPP (Screening Tool of Older Persons' potentially inappropriate Prescriptions) criteria are significantly associated with ADEs in older people with acute illness. METHODS: We prospectively studied 600 consecutive patients 65 years or older who were admitted with acute illness to a university teaching hospital over a 4-month interval. Potentially inappropriate medicines were defined by both Beers and STOPP criteria. Adverse drug events were defined by World Health Organization-Uppsala Monitoring Centre criteria and verified by a local expert consensus panel, which also assessed whether ADEs were causal or contributory to current hospitalization. Hallas criteria defined ADE avoidability. We compared the proportions of patients taking Beers criteria PIMs and STOPP criteria PIMs with avoidable ADEs that were causal or contributory to admission. RESULTS: A total of 329 ADEs were detected in 158 of 600 patients (26.3%); 219 of 329 ADEs (66.6%) were considered causal or contributory to admission. Of the 219 ADEs, 151 (68.9%) considered causal or contributory to admission were avoidable or potentially avoidable. After adjusting for age, sex, comorbidity, dementia, baseline activities of daily living function, and number of medications, the likelihood of a serious avoidable ADE increased significantly when STOPP PIMs were prescribed (odds ratio, 1.847; 95% confidence interval [CI], 1.506-2.264; P < .001); prescription of Beers criteria PIMs did not significantly increase ADE risk (odds ratio, 1.276; 95% CI, 0.945-1.722; P = .11). CONCLUSION: STOPP criteria PIMs, unlike Beers criteria PIMs, are significantly associated with avoidable ADEs in older people that cause or contribute to urgent hospitalization.
MeSH:
Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Chi-Square Distribution; Comorbidity; Drug Toxicity; Humans; Inappropriate Prescribing; Inpatients; Ireland; Medication Errors; Pharmaceutical Preparations; Polypharmacy; Prospective Studies; Regression Analysis; Risk
ISSN:
1538-3679

Full metadata record

DC FieldValue Language
dc.contributor.authorHamilton, Hilaryen
dc.contributor.authorGallagher, Paulen
dc.contributor.authorRyan, Cristinen
dc.contributor.authorByrne, Stephenen
dc.contributor.authorO'Mahony, Denisen
dc.date.accessioned2011-12-22T15:21:19Z-
dc.date.available2011-12-22T15:21:19Z-
dc.date.issued2011-06-13-
dc.identifier.citationPotentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patients. 2011, 171 (11):1013-9 Arch. Intern. Med.en
dc.identifier.issn1538-3679-
dc.identifier.pmid21670370-
dc.identifier.doi10.1001/archinternmed.2011.215-
dc.identifier.urihttp://hdl.handle.net/10147/198728-
dc.descriptionBACKGROUND: Previous studies have not demonstrated a consistent association between potentially inappropriate medicines (PIMs) in older patients as defined by Beers criteria and avoidable adverse drug events (ADEs). This study aimed to assess whether PIMs defined by new STOPP (Screening Tool of Older Persons' potentially inappropriate Prescriptions) criteria are significantly associated with ADEs in older people with acute illness. METHODS: We prospectively studied 600 consecutive patients 65 years or older who were admitted with acute illness to a university teaching hospital over a 4-month interval. Potentially inappropriate medicines were defined by both Beers and STOPP criteria. Adverse drug events were defined by World Health Organization-Uppsala Monitoring Centre criteria and verified by a local expert consensus panel, which also assessed whether ADEs were causal or contributory to current hospitalization. Hallas criteria defined ADE avoidability. We compared the proportions of patients taking Beers criteria PIMs and STOPP criteria PIMs with avoidable ADEs that were causal or contributory to admission. RESULTS: A total of 329 ADEs were detected in 158 of 600 patients (26.3%); 219 of 329 ADEs (66.6%) were considered causal or contributory to admission. Of the 219 ADEs, 151 (68.9%) considered causal or contributory to admission were avoidable or potentially avoidable. After adjusting for age, sex, comorbidity, dementia, baseline activities of daily living function, and number of medications, the likelihood of a serious avoidable ADE increased significantly when STOPP PIMs were prescribed (odds ratio, 1.847; 95% confidence interval [CI], 1.506-2.264; P < .001); prescription of Beers criteria PIMs did not significantly increase ADE risk (odds ratio, 1.276; 95% CI, 0.945-1.722; P = .11). CONCLUSION: STOPP criteria PIMs, unlike Beers criteria PIMs, are significantly associated with avoidable ADEs in older people that cause or contribute to urgent hospitalization.en
dc.description.abstractPrevious studies have not demonstrated a consistent association between potentially inappropriate medicines (PIMs) in older patients as defined by Beers criteria and avoidable adverse drug events (ADEs). This study aimed to assess whether PIMs defined by new STOPP (Screening Tool of Older Persons' potentially inappropriate Prescriptions) criteria are significantly associated with ADEs in older people with acute illness.-
dc.description.abstractWe prospectively studied 600 consecutive patients 65 years or older who were admitted with acute illness to a university teaching hospital over a 4-month interval. Potentially inappropriate medicines were defined by both Beers and STOPP criteria. Adverse drug events were defined by World Health Organization-Uppsala Monitoring Centre criteria and verified by a local expert consensus panel, which also assessed whether ADEs were causal or contributory to current hospitalization. Hallas criteria defined ADE avoidability. We compared the proportions of patients taking Beers criteria PIMs and STOPP criteria PIMs with avoidable ADEs that were causal or contributory to admission.-
dc.description.abstractA total of 329 ADEs were detected in 158 of 600 patients (26.3%); 219 of 329 ADEs (66.6%) were considered causal or contributory to admission. Of the 219 ADEs, 151 (68.9%) considered causal or contributory to admission were avoidable or potentially avoidable. After adjusting for age, sex, comorbidity, dementia, baseline activities of daily living function, and number of medications, the likelihood of a serious avoidable ADE increased significantly when STOPP PIMs were prescribed (odds ratio, 1.847; 95% confidence interval [CI], 1.506-2.264; P < .001); prescription of Beers criteria PIMs did not significantly increase ADE risk (odds ratio, 1.276; 95% CI, 0.945-1.722; P = .11).-
dc.description.abstractSTOPP criteria PIMs, unlike Beers criteria PIMs, are significantly associated with avoidable ADEs in older people that cause or contribute to urgent hospitalization.-
dc.language.isoenen
dc.subject.meshAdverse Drug Reaction Reporting Systems-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshChi-Square Distribution-
dc.subject.meshComorbidity-
dc.subject.meshDrug Toxicity-
dc.subject.meshHumans-
dc.subject.meshInappropriate Prescribing-
dc.subject.meshInpatients-
dc.subject.meshIreland-
dc.subject.meshMedication Errors-
dc.subject.meshPharmaceutical Preparations-
dc.subject.meshPolypharmacy-
dc.subject.meshProspective Studies-
dc.subject.meshRegression Analysis-
dc.subject.meshRisk-
dc.titlePotentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patients.en
dc.typeArticleen
dc.contributor.departmentDepartment of Medicine, School of Medicine, University College Cork, Ireland.en
dc.identifier.journalArchives of internal medicineen
dc.description.provinceMunster-

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.