The incidence and clinical correlates of lithium toxicity: a retrospective review.

Hdl Handle:
http://hdl.handle.net/10147/197886
Title:
The incidence and clinical correlates of lithium toxicity: a retrospective review.
Authors:
Dennison, U; Clarkson, M; O'Mullane, J; Cassidy, E M
Affiliation:
Department of Psychiatry, Cork University Hospital, Cork, Ireland. una.dennison@hse.ie
Citation:
The incidence and clinical correlates of lithium toxicity: a retrospective review. 2011, 180 (3):661-5 Ir J Med Sci
Journal:
Irish journal of medical science
Issue Date:
Sep-2011
URI:
http://hdl.handle.net/10147/197886
DOI:
10.1007/s11845-011-0712-6
PubMed ID:
21516355
Abstract:
Lithium is a commonly prescribed pharmacological treatment for mood disorders. It is associated with a number of side effects and potentially serious toxicity. To date, there is little data from Irish samples on the subject of Lithium toxicity.; To examine the incidence and clinical correlates of lithium toxicity in Cork, Ireland.; Our study identified 130 cases of biochemical lithium toxicity over 5 years, with an incidence rate of approximately 5.4 cases per 100,000 per year. Mean toxic lithium level was 2.16 mmol/L ±SD 0.87 mmol/L. Of these, 36% cases were reviewed medically in the general hospital at the time of toxicity. A number of issues in relation to lithium toxicity were identified. Neurological symptoms were common, including tremor, confusion, ataxia, drowsiness. However, only 4.2% patients were reviewed by a neurologist while in hospital. Medications that interact with lithium were found in 50% cases, with significant polypharmacy in 15%. The psychiatric services were involved in patient care in 76% cases, and 85% patients presenting with toxicity were reviewed by a psychiatrist. Rates of admission to hospital and haemodialysis were 70 and 11%, respectively.; Improvements in the standards of care in relation to lithium prescribing are required.
Item Type:
Article
Language:
en
Description:
BACKGROUND: Lithium is a commonly prescribed pharmacological treatment for mood disorders. It is associated with a number of side effects and potentially serious toxicity. To date, there is little data from Irish samples on the subject of Lithium toxicity. AIM: To examine the incidence and clinical correlates of lithium toxicity in Cork, Ireland. RESULTS: Our study identified 130 cases of biochemical lithium toxicity over 5 years, with an incidence rate of approximately 5.4 cases per 100,000 per year. Mean toxic lithium level was 2.16 mmol/L ±SD 0.87 mmol/L. Of these, 36% cases were reviewed medically in the general hospital at the time of toxicity. A number of issues in relation to lithium toxicity were identified. Neurological symptoms were common, including tremor, confusion, ataxia, drowsiness. However, only 4.2% patients were reviewed by a neurologist while in hospital. Medications that interact with lithium were found in 50% cases, with significant polypharmacy in 15%. The psychiatric services were involved in patient care in 76% cases, and 85% patients presenting with toxicity were reviewed by a psychiatrist. Rates of admission to hospital and haemodialysis were 70 and 11%, respectively. CONCLUSION: Improvements in the standards of care in relation to lithium prescribing are required.
MeSH:
Adult; Aged; Aged, 80 and over; Confusion; Female; Humans; Lithium; Male; Middle Aged; Mood Disorders; Retrospective Studies; Standard of Care; Tremor
ISSN:
1863-4362

Full metadata record

DC FieldValue Language
dc.contributor.authorDennison, Uen
dc.contributor.authorClarkson, Men
dc.contributor.authorO'Mullane, Jen
dc.contributor.authorCassidy, E Men
dc.date.accessioned2011-12-19T16:46:16Z-
dc.date.available2011-12-19T16:46:16Z-
dc.date.issued2011-09-
dc.identifier.citationThe incidence and clinical correlates of lithium toxicity: a retrospective review. 2011, 180 (3):661-5 Ir J Med Scien
dc.identifier.issn1863-4362-
dc.identifier.pmid21516355-
dc.identifier.doi10.1007/s11845-011-0712-6-
dc.identifier.urihttp://hdl.handle.net/10147/197886-
dc.descriptionBACKGROUND: Lithium is a commonly prescribed pharmacological treatment for mood disorders. It is associated with a number of side effects and potentially serious toxicity. To date, there is little data from Irish samples on the subject of Lithium toxicity. AIM: To examine the incidence and clinical correlates of lithium toxicity in Cork, Ireland. RESULTS: Our study identified 130 cases of biochemical lithium toxicity over 5 years, with an incidence rate of approximately 5.4 cases per 100,000 per year. Mean toxic lithium level was 2.16 mmol/L ±SD 0.87 mmol/L. Of these, 36% cases were reviewed medically in the general hospital at the time of toxicity. A number of issues in relation to lithium toxicity were identified. Neurological symptoms were common, including tremor, confusion, ataxia, drowsiness. However, only 4.2% patients were reviewed by a neurologist while in hospital. Medications that interact with lithium were found in 50% cases, with significant polypharmacy in 15%. The psychiatric services were involved in patient care in 76% cases, and 85% patients presenting with toxicity were reviewed by a psychiatrist. Rates of admission to hospital and haemodialysis were 70 and 11%, respectively. CONCLUSION: Improvements in the standards of care in relation to lithium prescribing are required.en
dc.description.abstractLithium is a commonly prescribed pharmacological treatment for mood disorders. It is associated with a number of side effects and potentially serious toxicity. To date, there is little data from Irish samples on the subject of Lithium toxicity.-
dc.description.abstractTo examine the incidence and clinical correlates of lithium toxicity in Cork, Ireland.-
dc.description.abstractOur study identified 130 cases of biochemical lithium toxicity over 5 years, with an incidence rate of approximately 5.4 cases per 100,000 per year. Mean toxic lithium level was 2.16 mmol/L ±SD 0.87 mmol/L. Of these, 36% cases were reviewed medically in the general hospital at the time of toxicity. A number of issues in relation to lithium toxicity were identified. Neurological symptoms were common, including tremor, confusion, ataxia, drowsiness. However, only 4.2% patients were reviewed by a neurologist while in hospital. Medications that interact with lithium were found in 50% cases, with significant polypharmacy in 15%. The psychiatric services were involved in patient care in 76% cases, and 85% patients presenting with toxicity were reviewed by a psychiatrist. Rates of admission to hospital and haemodialysis were 70 and 11%, respectively.-
dc.description.abstractImprovements in the standards of care in relation to lithium prescribing are required.-
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshConfusion-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLithium-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMood Disorders-
dc.subject.meshRetrospective Studies-
dc.subject.meshStandard of Care-
dc.subject.meshTremor-
dc.titleThe incidence and clinical correlates of lithium toxicity: a retrospective review.en
dc.typeArticleen
dc.contributor.departmentDepartment of Psychiatry, Cork University Hospital, Cork, Ireland. una.dennison@hse.ieen
dc.identifier.journalIrish journal of medical scienceen
dc.description.provinceMunster-

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