Persistent pain after mastectomy with reconstruction.

Hdl Handle:
http://hdl.handle.net/10147/197881
Title:
Persistent pain after mastectomy with reconstruction.
Authors:
Hickey, Oonagh T; Nugent, Nora F; Burke, Siun M; Hafeez, Parvaiz; Mudrakouski, Aliaksandr L; Shorten, George D
Affiliation:
Department of Anaesthesia, Cork University Hospital and University College, Wilton, Cork City, County Cork, Ireland. oonaghhickey@yahoo.co.uk
Citation:
Persistent pain after mastectomy with reconstruction. 2011, 23 (6):482-8 J Clin Anesth
Journal:
Journal of clinical anesthesia
Issue Date:
Sep-2011
URI:
http://hdl.handle.net/10147/197881
DOI:
10.1016/j.jclinane.2011.01.009
PubMed ID:
21911195
Abstract:
To determine the prevalence of persistent postsurgical pain (PPSP) and its influence on functional status, and to examine associations between PPSP and single nucleotide polymorphisms of the catechol-O-methyltransferase (COMT) gene and the guanosine triphosphate cyclohydrolase 1 (GCH1) gene following mastectomy and reconstruction.; Retrospective study.; Two teaching hospitals.; From the population of women who had undergone breast reconstruction following mastectomy for breast cancer over a 6-year period, 42 women agreed to participate in the assessment (55.3% of the total sample).; The Rand 36-Item Health Survey 1.0, the Patient-Specific Functional Scale, the McGill Pain Questionnaire (long form), visual analog scales for anxiety and pain, and the Hospital Anxiety and Depression Scale were administered. Blood was taken for genetic analysis. Quantitative sensory testing was performed using a standard electrical stimulus.; Surgical procedures, perioperative analgesic requirements, pain scores, and adjuvant therapies were noted. Height, weight, menstrual status, and arm circumference also were recorded.; 42 (55.3%) patients took part in the assessment, and 18 (43%) reported PPSP. Those with PPSP achieved lower scores on the Patient-Specific Functional Scale (P = 0.040) and had been given more morphine perioperatively. A trend was noted between occurrence of PPSP and the val158met polymorphism of the COMT gene (P = 0.06).; Persistent pain after mastectomy and breast reconstruction has a high prevalence (43%). Genetic mutations may contribute to the development of persistent pain following surgery; however, larger studies are required for confirmation.
Item Type:
Article
Language:
en
ISSN:
1873-4529

Full metadata record

DC FieldValue Language
dc.contributor.authorHickey, Oonagh Ten
dc.contributor.authorNugent, Nora Fen
dc.contributor.authorBurke, Siun Men
dc.contributor.authorHafeez, Parvaizen
dc.contributor.authorMudrakouski, Aliaksandr Len
dc.contributor.authorShorten, George Den
dc.date.accessioned2011-12-19T16:37:53Z-
dc.date.available2011-12-19T16:37:53Z-
dc.date.issued2011-09-
dc.identifier.citationPersistent pain after mastectomy with reconstruction. 2011, 23 (6):482-8 J Clin Anesthen
dc.identifier.issn1873-4529-
dc.identifier.pmid21911195-
dc.identifier.doi10.1016/j.jclinane.2011.01.009-
dc.identifier.urihttp://hdl.handle.net/10147/197881-
dc.description.abstractTo determine the prevalence of persistent postsurgical pain (PPSP) and its influence on functional status, and to examine associations between PPSP and single nucleotide polymorphisms of the catechol-O-methyltransferase (COMT) gene and the guanosine triphosphate cyclohydrolase 1 (GCH1) gene following mastectomy and reconstruction.-
dc.description.abstractRetrospective study.-
dc.description.abstractTwo teaching hospitals.-
dc.description.abstractFrom the population of women who had undergone breast reconstruction following mastectomy for breast cancer over a 6-year period, 42 women agreed to participate in the assessment (55.3% of the total sample).-
dc.description.abstractThe Rand 36-Item Health Survey 1.0, the Patient-Specific Functional Scale, the McGill Pain Questionnaire (long form), visual analog scales for anxiety and pain, and the Hospital Anxiety and Depression Scale were administered. Blood was taken for genetic analysis. Quantitative sensory testing was performed using a standard electrical stimulus.-
dc.description.abstractSurgical procedures, perioperative analgesic requirements, pain scores, and adjuvant therapies were noted. Height, weight, menstrual status, and arm circumference also were recorded.-
dc.description.abstract42 (55.3%) patients took part in the assessment, and 18 (43%) reported PPSP. Those with PPSP achieved lower scores on the Patient-Specific Functional Scale (P = 0.040) and had been given more morphine perioperatively. A trend was noted between occurrence of PPSP and the val158met polymorphism of the COMT gene (P = 0.06).-
dc.description.abstractPersistent pain after mastectomy and breast reconstruction has a high prevalence (43%). Genetic mutations may contribute to the development of persistent pain following surgery; however, larger studies are required for confirmation.-
dc.language.isoenen
dc.titlePersistent pain after mastectomy with reconstruction.en
dc.typeArticleen
dc.contributor.departmentDepartment of Anaesthesia, Cork University Hospital and University College, Wilton, Cork City, County Cork, Ireland. oonaghhickey@yahoo.co.uken
dc.identifier.journalJournal of clinical anesthesiaen
dc.description.provinceMunster-

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