Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis.

Hdl Handle:
http://hdl.handle.net/10147/197853
Title:
Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis.
Authors:
Allen, Edith M; Matthews, John B; O' Halloran, Domhnall J; Griffiths, Helen R; Chapple, Iain L
Affiliation:
Department of Restorative Dentistry, Cork University Dental School and Hospital, Wilton, Ireland. e.allen@ucc.ie
Citation:
Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis. 2011, 38 (10):894-901 J. Clin. Periodontol.
Journal:
Journal of clinical periodontology
Issue Date:
Oct-2011
URI:
http://hdl.handle.net/10147/197853
DOI:
10.1111/j.1600-051X.2011.01764.x
PubMed ID:
21883360
Abstract:
To determine the impact of periodontitis on oxidative/inflammatory status and diabetes control in Type 2 diabetes.; A comparative study of 20 Type 2 diabetes patients with periodontitis [body mass index (BMI) 31+5], 20-age/gender-matched, non-periodontitis Type 2 diabetes controls (BMI 29+6) and 20 non-diabetes periodontitis controls (BMI 25+4) had periodontal examinations and fasting blood samples collected. Oxidative stress was determined by plasma small molecule antioxidant capacity (pSMAC) and protein carbonyl levels; inflammatory status by total/differential leucocytes, fibrinogen and high sensitivity C-reactive protein (hsCRP); diabetes status by fasting glucose, HbA1c, lipid profile, insulin resistance and secretion. Statistical analysis was performed using SPSS.; pSMAC was lower (p=0.03) and protein carbonyls higher (p=0.007) in Type 2 diabetes patients with periodontitis compared with those without periodontitis. Periodontitis was associated with significantly higher HbA1c (p=0.002) and fasting glucose levels (p=0.04) and with lower β-cell function (HOMA-β; p=0.01) in diabetes patients. Periodontitis had little effect on inflammatory markers or lipid profiles, but Type 2 diabetes patients with periodontitis had higher levels of hsCRP than those without diabetes (p=0.004) and the lowest levels of HDL-cholesterol of all groups.; Periodontitis is associated with increased oxidative stress and compromised glycaemic control in Type 2 diabetes patients.
Item Type:
Article
Language:
en
ISSN:
1600-051X

Full metadata record

DC FieldValue Language
dc.contributor.authorAllen, Edith Men
dc.contributor.authorMatthews, John Ben
dc.contributor.authorO' Halloran, Domhnall Jen
dc.contributor.authorGriffiths, Helen Ren
dc.contributor.authorChapple, Iain Len
dc.date.accessioned2011-12-19T16:26:58Z-
dc.date.available2011-12-19T16:26:58Z-
dc.date.issued2011-10-
dc.identifier.citationOxidative and inflammatory status in Type 2 diabetes patients with periodontitis. 2011, 38 (10):894-901 J. Clin. Periodontol.en
dc.identifier.issn1600-051X-
dc.identifier.pmid21883360-
dc.identifier.doi10.1111/j.1600-051X.2011.01764.x-
dc.identifier.urihttp://hdl.handle.net/10147/197853-
dc.description.abstractTo determine the impact of periodontitis on oxidative/inflammatory status and diabetes control in Type 2 diabetes.-
dc.description.abstractA comparative study of 20 Type 2 diabetes patients with periodontitis [body mass index (BMI) 31+5], 20-age/gender-matched, non-periodontitis Type 2 diabetes controls (BMI 29+6) and 20 non-diabetes periodontitis controls (BMI 25+4) had periodontal examinations and fasting blood samples collected. Oxidative stress was determined by plasma small molecule antioxidant capacity (pSMAC) and protein carbonyl levels; inflammatory status by total/differential leucocytes, fibrinogen and high sensitivity C-reactive protein (hsCRP); diabetes status by fasting glucose, HbA1c, lipid profile, insulin resistance and secretion. Statistical analysis was performed using SPSS.-
dc.description.abstractpSMAC was lower (p=0.03) and protein carbonyls higher (p=0.007) in Type 2 diabetes patients with periodontitis compared with those without periodontitis. Periodontitis was associated with significantly higher HbA1c (p=0.002) and fasting glucose levels (p=0.04) and with lower β-cell function (HOMA-β; p=0.01) in diabetes patients. Periodontitis had little effect on inflammatory markers or lipid profiles, but Type 2 diabetes patients with periodontitis had higher levels of hsCRP than those without diabetes (p=0.004) and the lowest levels of HDL-cholesterol of all groups.-
dc.description.abstractPeriodontitis is associated with increased oxidative stress and compromised glycaemic control in Type 2 diabetes patients.-
dc.language.isoenen
dc.titleOxidative and inflammatory status in Type 2 diabetes patients with periodontitis.en
dc.typeArticleen
dc.contributor.departmentDepartment of Restorative Dentistry, Cork University Dental School and Hospital, Wilton, Ireland. e.allen@ucc.ieen
dc.identifier.journalJournal of clinical periodontologyen
dc.description.provinceMunster-
All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.