An Unusual Case of Marginal Zone B-Cell Lymphoma Arising in the Breast – Its Diagnosis and the Role of Radiotherapy in its Management

Hdl Handle:
http://hdl.handle.net/10147/190731
Title:
An Unusual Case of Marginal Zone B-Cell Lymphoma Arising in the Breast – Its Diagnosis and the Role of Radiotherapy in its Management
Authors:
Rock, Kathy; Rangaswamy, G; O'Sullivan, S.; Coffey, J.
Affiliation:
Department of Radiation Oncology, St. Luke’s Hospital, Rathgar, Dublin 6, Ireland
Citation:
Breast Care 2011;6:391-393
Publisher:
Karger
Journal:
Breast Care: multidisciplinary journal for research, diagnosis & therapy
Issue Date:
2011
URI:
http://hdl.handle.net/10147/190731
Item Type:
Article
Description:
Background: Primary lymphoma of the breast accounts for 0.04–0.5% of all breast malignancies and approximately 1% of all extranodal lymphomas. For stage IE node-negative disease, involved field radiotherapy is recommended except for very young women in whom the risk of breast cancer is a concern. The rate of complete response for limited stage extranodal marginal B-cell lymphoma is in excess of 90%. Case Report: We report the case of a 62-year-old lady who presented with a unilateral painless palpable right breast lump. She subsequently underwent a trucut biopsy of the lesion. The histology revealed a low-grade B-cell non-Hodgkin‘s lymphoma (NHL). Immunohistochemistry showed that more than 95% of the cells were B cells which were CD 20+/CD 45+ and BC L6+. This confirmed the diagnosis of marginal zone lymphoma. Staging work-up was negative for distant metastases. Serum alkaline phosphatase and lactate dehydrogenase were normal. The patient had no ‘B’ symptoms. Her final diagnosis was clinical stage IAE NHL, and she was referred for curative radiotherapy. Conclusion: Radiation treatment is a safe and extremely effective modality of treatment for early stage I marginal zone B-cell lymphomas of the breast.
Local subject classification:
Marginal zone B-cell lymphoma; Breast; Non-Hodgkin‘s lymphoma; Involved field radiotherapy
ISSN:
1661-3791

Full metadata record

DC FieldValue Language
dc.contributor.authorRock, Kathyen
dc.contributor.authorRangaswamy, Gen
dc.contributor.authorO'Sullivan, S.en
dc.contributor.authorCoffey, J.en
dc.date.accessioned2011-11-24T14:09:16Z-
dc.date.available2011-11-24T14:09:16Z-
dc.date.issued2011-
dc.identifier.citationBreast Care 2011;6:391-393en
dc.identifier.issn1661-3791-
dc.identifier.urihttp://hdl.handle.net/10147/190731-
dc.descriptionBackground: Primary lymphoma of the breast accounts for 0.04–0.5% of all breast malignancies and approximately 1% of all extranodal lymphomas. For stage IE node-negative disease, involved field radiotherapy is recommended except for very young women in whom the risk of breast cancer is a concern. The rate of complete response for limited stage extranodal marginal B-cell lymphoma is in excess of 90%. Case Report: We report the case of a 62-year-old lady who presented with a unilateral painless palpable right breast lump. She subsequently underwent a trucut biopsy of the lesion. The histology revealed a low-grade B-cell non-Hodgkin‘s lymphoma (NHL). Immunohistochemistry showed that more than 95% of the cells were B cells which were CD 20+/CD 45+ and BC L6+. This confirmed the diagnosis of marginal zone lymphoma. Staging work-up was negative for distant metastases. Serum alkaline phosphatase and lactate dehydrogenase were normal. The patient had no ‘B’ symptoms. Her final diagnosis was clinical stage IAE NHL, and she was referred for curative radiotherapy. Conclusion: Radiation treatment is a safe and extremely effective modality of treatment for early stage I marginal zone B-cell lymphomas of the breast.en
dc.publisherKargeren
dc.subject.otherMarginal zone B-cell lymphomaen
dc.subject.otherBreasten
dc.subject.otherNon-Hodgkin‘s lymphomaen
dc.subject.otherInvolved field radiotherapyen
dc.titleAn Unusual Case of Marginal Zone B-Cell Lymphoma Arising in the Breast – Its Diagnosis and the Role of Radiotherapy in its Managementen
dc.typeArticleen
dc.contributor.departmentDepartment of Radiation Oncology, St. Luke’s Hospital, Rathgar, Dublin 6, Irelanden
dc.identifier.journalBreast Care: multidisciplinary journal for research, diagnosis & therapyen
dc.description.provinceLeinster-
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