Influence of maternal BMI on genetic sonography in the FaSTER trial.

Hdl Handle:
http://hdl.handle.net/10147/189991
Title:
Influence of maternal BMI on genetic sonography in the FaSTER trial.
Authors:
Aagaard-Tillery, Kjersti M; Flint Porter, T; Malone, Fergal D; Nyberg, David A; Collins, Jamie; Comstock, Christine H; Hankins, Gary; Eddleman, Keith; Dugoff, Lorraine; Wolfe, Honor M; D'Alton, Mary E
Affiliation:
University of Utah, Salt Lake City, UT, USA. aagaardt@bcm.tmc.edu
Citation:
Influence of maternal BMI on genetic sonography in the FaSTER trial. 2010, 30 (1):14-22 Prenat. Diagn.
Journal:
Prenatal diagnosis
Issue Date:
Jan-2010
URI:
http://hdl.handle.net/10147/189991
DOI:
10.1002/pd.2399
PubMed ID:
19918963
Additional Links:
http://onlinelibrary.wiley.com/doi/10.1002/pd.2399/abstract
Abstract:
We sought to evaluate the influence of maternal body mass index (BMI) on sonographic detection employing data from the FaSTER trial.; Unselected singleton pregnancies underwent detailed genetic sonogram to evaluate for structural fetal anomalies and soft markers for aneuploidy. BMI (kg/m(2)) were calculated from reported initial visit values. Sensitivity, specificity, false positive and false negative rates (FPR and FNR), likelihood ratio, detection rates, and a missed diagnosis rate (MDR: FNR + marker recorded as 'missing'/N) were calculated.; Eight thousand five hundred and fifty-five patients with complete BMI information had detailed genetic sonography. A lower sensitivity with an elevated FNR and MDR was observed in obese women for multiple aneuploid markers (e.g. > or =2 markers 32% sensitivity with 68% FNR among BMI <25 vs 22% and 78% among BMI >30). Similarly, the detection rate for cardiac anomalies among women at BMI <25 was higher (21.6%) at a significantly lower FPR (78.4%; 95% CI 77.3-79.5%) in comparison to obese women (8.3% with FPR 91.7%; 95% CI 90.1-93.2%). In a logistic regression model, maternal obesity significantly decreased the likelihood of sonographic detection of common anomalies (adjusted OR 0.7; 95% CI 0.6-0.9; p = 0.001).; The performance of second trimester genetic sonography is influenced by obesity, with a significantly higher MDR for multiple minor markers and lower likelihood for detecting common anomalies.
Item Type:
Article
Language:
en
Description:
OBJECTIVE: We sought to evaluate the influence of maternal body mass index (BMI) on sonographic detection employing data from the FaSTER trial. METHOD: Unselected singleton pregnancies underwent detailed genetic sonogram to evaluate for structural fetal anomalies and soft markers for aneuploidy. BMI (kg/m(2)) were calculated from reported initial visit values. Sensitivity, specificity, false positive and false negative rates (FPR and FNR), likelihood ratio, detection rates, and a missed diagnosis rate (MDR: FNR + marker recorded as 'missing'/N) were calculated. RESULTS: Eight thousand five hundred and fifty-five patients with complete BMI information had detailed genetic sonography. A lower sensitivity with an elevated FNR and MDR was observed in obese women for multiple aneuploid markers (e.g. > or =2 markers 32% sensitivity with 68% FNR among BMI <25 vs 22% and 78% among BMI >30). Similarly, the detection rate for cardiac anomalies among women at BMI <25 was higher (21.6%) at a significantly lower FPR (78.4%; 95% CI 77.3-79.5%) in comparison to obese women (8.3% with FPR 91.7%; 95% CI 90.1-93.2%). In a logistic regression model, maternal obesity significantly decreased the likelihood of sonographic detection of common anomalies (adjusted OR 0.7; 95% CI 0.6-0.9; p = 0.001). CONCLUSION: The performance of second trimester genetic sonography is influenced by obesity, with a significantly higher MDR for multiple minor markers and lower likelihood for detecting common anomalies.
MeSH:
Adult; Aneuploidy; Biological Markers; Body Mass Index; Congenital Abnormalities; Female; Genetic Testing; Heart Defects, Congenital; Humans; Obesity; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Prospective Studies; Ultrasonography, Prenatal
ISSN:
1097-0223

Full metadata record

DC FieldValue Language
dc.contributor.authorAagaard-Tillery, Kjersti Men
dc.contributor.authorFlint Porter, Ten
dc.contributor.authorMalone, Fergal Den
dc.contributor.authorNyberg, David Aen
dc.contributor.authorCollins, Jamieen
dc.contributor.authorComstock, Christine Hen
dc.contributor.authorHankins, Garyen
dc.contributor.authorEddleman, Keithen
dc.contributor.authorDugoff, Lorraineen
dc.contributor.authorWolfe, Honor Men
dc.contributor.authorD'Alton, Mary Een
dc.date.accessioned2011-11-18T15:29:23Z-
dc.date.available2011-11-18T15:29:23Z-
dc.date.issued2010-01-
dc.identifier.citationInfluence of maternal BMI on genetic sonography in the FaSTER trial. 2010, 30 (1):14-22 Prenat. Diagn.en
dc.identifier.issn1097-0223-
dc.identifier.pmid19918963-
dc.identifier.doi10.1002/pd.2399-
dc.identifier.urihttp://hdl.handle.net/10147/189991-
dc.descriptionOBJECTIVE: We sought to evaluate the influence of maternal body mass index (BMI) on sonographic detection employing data from the FaSTER trial. METHOD: Unselected singleton pregnancies underwent detailed genetic sonogram to evaluate for structural fetal anomalies and soft markers for aneuploidy. BMI (kg/m(2)) were calculated from reported initial visit values. Sensitivity, specificity, false positive and false negative rates (FPR and FNR), likelihood ratio, detection rates, and a missed diagnosis rate (MDR: FNR + marker recorded as 'missing'/N) were calculated. RESULTS: Eight thousand five hundred and fifty-five patients with complete BMI information had detailed genetic sonography. A lower sensitivity with an elevated FNR and MDR was observed in obese women for multiple aneuploid markers (e.g. > or =2 markers 32% sensitivity with 68% FNR among BMI <25 vs 22% and 78% among BMI >30). Similarly, the detection rate for cardiac anomalies among women at BMI <25 was higher (21.6%) at a significantly lower FPR (78.4%; 95% CI 77.3-79.5%) in comparison to obese women (8.3% with FPR 91.7%; 95% CI 90.1-93.2%). In a logistic regression model, maternal obesity significantly decreased the likelihood of sonographic detection of common anomalies (adjusted OR 0.7; 95% CI 0.6-0.9; p = 0.001). CONCLUSION: The performance of second trimester genetic sonography is influenced by obesity, with a significantly higher MDR for multiple minor markers and lower likelihood for detecting common anomalies.en
dc.description.abstractWe sought to evaluate the influence of maternal body mass index (BMI) on sonographic detection employing data from the FaSTER trial.-
dc.description.abstractUnselected singleton pregnancies underwent detailed genetic sonogram to evaluate for structural fetal anomalies and soft markers for aneuploidy. BMI (kg/m(2)) were calculated from reported initial visit values. Sensitivity, specificity, false positive and false negative rates (FPR and FNR), likelihood ratio, detection rates, and a missed diagnosis rate (MDR: FNR + marker recorded as 'missing'/N) were calculated.-
dc.description.abstractEight thousand five hundred and fifty-five patients with complete BMI information had detailed genetic sonography. A lower sensitivity with an elevated FNR and MDR was observed in obese women for multiple aneuploid markers (e.g. > or =2 markers 32% sensitivity with 68% FNR among BMI <25 vs 22% and 78% among BMI >30). Similarly, the detection rate for cardiac anomalies among women at BMI <25 was higher (21.6%) at a significantly lower FPR (78.4%; 95% CI 77.3-79.5%) in comparison to obese women (8.3% with FPR 91.7%; 95% CI 90.1-93.2%). In a logistic regression model, maternal obesity significantly decreased the likelihood of sonographic detection of common anomalies (adjusted OR 0.7; 95% CI 0.6-0.9; p = 0.001).-
dc.description.abstractThe performance of second trimester genetic sonography is influenced by obesity, with a significantly higher MDR for multiple minor markers and lower likelihood for detecting common anomalies.-
dc.language.isoenen
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/pd.2399/abstracten
dc.subject.meshAdult-
dc.subject.meshAneuploidy-
dc.subject.meshBiological Markers-
dc.subject.meshBody Mass Index-
dc.subject.meshCongenital Abnormalities-
dc.subject.meshFemale-
dc.subject.meshGenetic Testing-
dc.subject.meshHeart Defects, Congenital-
dc.subject.meshHumans-
dc.subject.meshObesity-
dc.subject.meshPredictive Value of Tests-
dc.subject.meshPregnancy-
dc.subject.meshPregnancy Trimester, First-
dc.subject.meshPregnancy Trimester, Second-
dc.subject.meshProspective Studies-
dc.subject.meshUltrasonography, Prenatal-
dc.titleInfluence of maternal BMI on genetic sonography in the FaSTER trial.en
dc.typeArticleen
dc.contributor.departmentUniversity of Utah, Salt Lake City, UT, USA. aagaardt@bcm.tmc.eduen
dc.identifier.journalPrenatal diagnosisen
dc.description.provinceLeinster-

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