The relationship between maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGFBP-3 to gestational age and preterm delivery.

Hdl Handle:
http://hdl.handle.net/10147/189977
Title:
The relationship between maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGFBP-3 to gestational age and preterm delivery.
Authors:
Cooley, Sharon M; Donnelly, Jennifer C; Collins, Claire; Geary, Michael P; Rodeck, Charles H; Hindmarsh, Peter C
Affiliation:
Rotunda Hospital, Parnell Street, Dublin 1, Ireland. smcooley@hotmail.com
Citation:
The relationship between maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGFBP-3 to gestational age and preterm delivery. 2010, 38 (3):255-9 J Perinat Med
Journal:
Journal of perinatal medicine
Issue Date:
May-2010
URI:
http://hdl.handle.net/10147/189977
DOI:
10.1515/JPM.2010.019
PubMed ID:
20121533
Additional Links:
http://www.reference-global.com/doi/abs/10.1515/JPM.2010.019?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
Abstract:
To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational age at delivery.; Prospective cohort study of 1650 low-risk Caucasian women in a London University teaching hospital. Maternal IGF-1, IGF-2 and IGFBP-3 were measured in maternal blood at booking and analyzed with respect to gestational age at delivery.; There was no significant association between maternal IGF-1 or IGF-2 and preterm birth (PTB). A significant reduction in mean IGFBP-3 levels was noted with delivery <32 completed weeks (P=0.02).; Maternal mean IGFBP-3 levels are significantly reduced in cases complicated by delivery <32 completed weeks.
Item Type:
Article
Language:
en
Description:
AIMS: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational age at delivery. METHODS: Prospective cohort study of 1650 low-risk Caucasian women in a London University teaching hospital. Maternal IGF-1, IGF-2 and IGFBP-3 were measured in maternal blood at booking and analyzed with respect to gestational age at delivery. RESULTS: There was no significant association between maternal IGF-1 or IGF-2 and preterm birth (PTB). A significant reduction in mean IGFBP-3 levels was noted with delivery <32 completed weeks (P=0.02). CONCLUSION: Maternal mean IGFBP-3 levels are significantly reduced in cases complicated by delivery <32 completed weeks.
Keywords:
PREGNANCY; GROWTH
MeSH:
Adult; Alcohol Drinking; Cohort Studies; Female; Gestational Age; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Pregnancy; Premature Birth; Prospective Studies; Smoking
ISSN:
1619-3997

Full metadata record

DC FieldValue Language
dc.contributor.authorCooley, Sharon Men
dc.contributor.authorDonnelly, Jennifer Cen
dc.contributor.authorCollins, Claireen
dc.contributor.authorGeary, Michael Pen
dc.contributor.authorRodeck, Charles Hen
dc.contributor.authorHindmarsh, Peter Cen
dc.date.accessioned2011-11-18T15:13:52Z-
dc.date.available2011-11-18T15:13:52Z-
dc.date.issued2010-05-
dc.identifier.citationThe relationship between maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGFBP-3 to gestational age and preterm delivery. 2010, 38 (3):255-9 J Perinat Meden
dc.identifier.issn1619-3997-
dc.identifier.pmid20121533-
dc.identifier.doi10.1515/JPM.2010.019-
dc.identifier.urihttp://hdl.handle.net/10147/189977-
dc.descriptionAIMS: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational age at delivery. METHODS: Prospective cohort study of 1650 low-risk Caucasian women in a London University teaching hospital. Maternal IGF-1, IGF-2 and IGFBP-3 were measured in maternal blood at booking and analyzed with respect to gestational age at delivery. RESULTS: There was no significant association between maternal IGF-1 or IGF-2 and preterm birth (PTB). A significant reduction in mean IGFBP-3 levels was noted with delivery <32 completed weeks (P=0.02). CONCLUSION: Maternal mean IGFBP-3 levels are significantly reduced in cases complicated by delivery <32 completed weeks.en
dc.description.abstractTo investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational age at delivery.-
dc.description.abstractProspective cohort study of 1650 low-risk Caucasian women in a London University teaching hospital. Maternal IGF-1, IGF-2 and IGFBP-3 were measured in maternal blood at booking and analyzed with respect to gestational age at delivery.-
dc.description.abstractThere was no significant association between maternal IGF-1 or IGF-2 and preterm birth (PTB). A significant reduction in mean IGFBP-3 levels was noted with delivery <32 completed weeks (P=0.02).-
dc.description.abstractMaternal mean IGFBP-3 levels are significantly reduced in cases complicated by delivery <32 completed weeks.-
dc.language.isoenen
dc.relation.urlhttp://www.reference-global.com/doi/abs/10.1515/JPM.2010.019?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmeden
dc.subjectPREGNANCYen
dc.subjectGROWTHen
dc.subject.meshAdult-
dc.subject.meshAlcohol Drinking-
dc.subject.meshCohort Studies-
dc.subject.meshFemale-
dc.subject.meshGestational Age-
dc.subject.meshHumans-
dc.subject.meshInsulin-Like Growth Factor Binding Protein 3-
dc.subject.meshInsulin-Like Growth Factor I-
dc.subject.meshInsulin-Like Growth Factor II-
dc.subject.meshPregnancy-
dc.subject.meshPremature Birth-
dc.subject.meshProspective Studies-
dc.subject.meshSmoking-
dc.titleThe relationship between maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGFBP-3 to gestational age and preterm delivery.en
dc.typeArticleen
dc.contributor.departmentRotunda Hospital, Parnell Street, Dublin 1, Ireland. smcooley@hotmail.comen
dc.identifier.journalJournal of perinatal medicineen
dc.description.provinceLeinster-
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