Maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGF BP-3 and the hypertensive disorders of pregnancy.

Hdl Handle:
http://hdl.handle.net/10147/189975
Title:
Maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGF BP-3 and the hypertensive disorders of pregnancy.
Authors:
Cooley, Sharon M; Donnelly, Jennifer C; Geary, Michael P; Rodeck, Charles H; Hindmarsh, Peter C
Affiliation:
Rotunda Hospital, Parnell Street, Dublin 1, Ireland. smcooley@hotmail.com
Citation:
Maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGF BP-3 and the hypertensive disorders of pregnancy. 2010, 23 (7):658-61 J. Matern. Fetal. Neonatal. Med.
Journal:
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Issue Date:
Jul-2010
URI:
http://hdl.handle.net/10147/189975
DOI:
10.3109/14767050903301033
PubMed ID:
20540659
Additional Links:
http://informahealthcare.com/doi/abs/10.3109/14767050903301033
Abstract:
To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational hypertension and pre-eclampsia (PET).; Prospective cohort study of 1650 low-risk Caucasian women in a University teaching hospital in London. Statistical analysis was performed using commercial software (SPSS for Windows, version 6.1, SPSS, Chicago, IL), with P < 0.05 as significant. Maternal IGF 1, IGF 2 and IGF BP-3 were assessed on maternal blood at booking. Blood pressure was checked at each visit in conjunction with urine analysis. The Davey & MacGillivray 1988 classification system was used in making the diagnosis of PET.; There was no significant correlation between maternal IGF-1 or IGFBP-3 levels and gestational hypertension or PET. However, a significant positive correlation does exist between maternal IGF-2 levels and PET.; Maternal IGF-2 has a significant positive correlation with PET.
Item Type:
Article
Language:
en
Description:
OBJECTIVE: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational hypertension and pre-eclampsia (PET). METHODS: Prospective cohort study of 1650 low-risk Caucasian women in a University teaching hospital in London. Statistical analysis was performed using commercial software (SPSS for Windows, version 6.1, SPSS, Chicago, IL), with P < 0.05 as significant. Maternal IGF 1, IGF 2 and IGF BP-3 were assessed on maternal blood at booking. Blood pressure was checked at each visit in conjunction with urine analysis. The Davey & MacGillivray 1988 classification system was used in making the diagnosis of PET. RESULTS: There was no significant correlation between maternal IGF-1 or IGFBP-3 levels and gestational hypertension or PET. However, a significant positive correlation does exist between maternal IGF-2 levels and PET. CONCLUSIONS: Maternal IGF-2 has a significant positive correlation with PET.
MeSH:
Adult; Cohort Studies; Female; Humans; Hypertension, Pregnancy-Induced; Infant, Newborn; Infant, Newborn, Diseases; Insulin-Like Growth Factor Binding Proteins; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Intensive Care Units, Neonatal; Mothers; Patient Admission; Pregnancy; Pregnancy Outcome; Prognosis
ISSN:
1476-4954

Full metadata record

DC FieldValue Language
dc.contributor.authorCooley, Sharon Men
dc.contributor.authorDonnelly, Jennifer Cen
dc.contributor.authorGeary, Michael Pen
dc.contributor.authorRodeck, Charles Hen
dc.contributor.authorHindmarsh, Peter Cen
dc.date.accessioned2011-11-18T15:10:10Z-
dc.date.available2011-11-18T15:10:10Z-
dc.date.issued2010-07-
dc.identifier.citationMaternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGF BP-3 and the hypertensive disorders of pregnancy. 2010, 23 (7):658-61 J. Matern. Fetal. Neonatal. Med.en
dc.identifier.issn1476-4954-
dc.identifier.pmid20540659-
dc.identifier.doi10.3109/14767050903301033-
dc.identifier.urihttp://hdl.handle.net/10147/189975-
dc.descriptionOBJECTIVE: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational hypertension and pre-eclampsia (PET). METHODS: Prospective cohort study of 1650 low-risk Caucasian women in a University teaching hospital in London. Statistical analysis was performed using commercial software (SPSS for Windows, version 6.1, SPSS, Chicago, IL), with P < 0.05 as significant. Maternal IGF 1, IGF 2 and IGF BP-3 were assessed on maternal blood at booking. Blood pressure was checked at each visit in conjunction with urine analysis. The Davey & MacGillivray 1988 classification system was used in making the diagnosis of PET. RESULTS: There was no significant correlation between maternal IGF-1 or IGFBP-3 levels and gestational hypertension or PET. However, a significant positive correlation does exist between maternal IGF-2 levels and PET. CONCLUSIONS: Maternal IGF-2 has a significant positive correlation with PET.en
dc.description.abstractTo investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational hypertension and pre-eclampsia (PET).-
dc.description.abstractProspective cohort study of 1650 low-risk Caucasian women in a University teaching hospital in London. Statistical analysis was performed using commercial software (SPSS for Windows, version 6.1, SPSS, Chicago, IL), with P < 0.05 as significant. Maternal IGF 1, IGF 2 and IGF BP-3 were assessed on maternal blood at booking. Blood pressure was checked at each visit in conjunction with urine analysis. The Davey & MacGillivray 1988 classification system was used in making the diagnosis of PET.-
dc.description.abstractThere was no significant correlation between maternal IGF-1 or IGFBP-3 levels and gestational hypertension or PET. However, a significant positive correlation does exist between maternal IGF-2 levels and PET.-
dc.description.abstractMaternal IGF-2 has a significant positive correlation with PET.-
dc.language.isoenen
dc.relation.urlhttp://informahealthcare.com/doi/abs/10.3109/14767050903301033en
dc.subject.meshAdult-
dc.subject.meshCohort Studies-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshHypertension, Pregnancy-Induced-
dc.subject.meshInfant, Newborn-
dc.subject.meshInfant, Newborn, Diseases-
dc.subject.meshInsulin-Like Growth Factor Binding Proteins-
dc.subject.meshInsulin-Like Growth Factor I-
dc.subject.meshInsulin-Like Growth Factor II-
dc.subject.meshIntensive Care Units, Neonatal-
dc.subject.meshMothers-
dc.subject.meshPatient Admission-
dc.subject.meshPregnancy-
dc.subject.meshPregnancy Outcome-
dc.subject.meshPrognosis-
dc.titleMaternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGF BP-3 and the hypertensive disorders of pregnancy.en
dc.typeArticleen
dc.contributor.departmentRotunda Hospital, Parnell Street, Dublin 1, Ireland. smcooley@hotmail.comen
dc.identifier.journalThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetriciansen
dc.description.provinceLeinster-

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