All azoospermic males should be screened for cystic fibrosis mutations before intracytoplasmic sperm injection.

Hdl Handle:
http://hdl.handle.net/10147/189953
Title:
All azoospermic males should be screened for cystic fibrosis mutations before intracytoplasmic sperm injection.
Authors:
Mocanu, Edgar; Shattock, Richard; Barton, David; Rogers, Melissa; Conroy, Ronan; Sheils, Orla; Collins, Claire; Martin, Cara; Harrison, Robert; O'Leary, John
Affiliation:
Human Assisted Reproduction Ireland, Rotunda Hospital, and Royal College of Surgeons in Ireland, Dublin, Ireland. emocanu@rcsi.ie
Citation:
All azoospermic males should be screened for cystic fibrosis mutations before intracytoplasmic sperm injection. 2010, 94 (6):2448-50 Fertil. Steril.
Journal:
Fertility and sterility
Issue Date:
Nov-2010
URI:
http://hdl.handle.net/10147/189953
DOI:
10.1016/j.fertnstert.2010.02.029
PubMed ID:
20381036
Additional Links:
http://www.sciencedirect.com/science/article/pii/S0015028210003080
Abstract:
We assessed the frequency of CFTR mutations in groups with varying degrees of sub-fertility and compared these groups to a fertile male group with proven paternity. Screening for CFTR mutations should be routine for all azoospermic males, irrespective of obstructive or non-obstructive etiology, prior to proposing ICSI treatment. CFTR testing has no value in the investigation of non-azoospermic infertile males.
Item Type:
Article
Language:
en
Description:
We assessed the frequency of CFTR mutations in groups with varying degrees of sub-fertility and compared these groups to a fertile male group with proven paternity. Screening for CFTR mutations should be routine for all azoospermic males, irrespective of obstructive or non-obstructive etiology, prior to proposing ICSI treatment. CFTR testing has no value in the investigation of non-azoospermic infertile males.
Keywords:
FERTILITY
MeSH:
Azoospermia; Case-Control Studies; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; DNA Mutational Analysis; Gene Frequency; Genetic Testing; Heterozygote Detection; Humans; Infertility, Male; Male; Mutation; Predictive Value of Tests; Prognosis; Sperm Injections, Intracytoplasmic
ISSN:
1556-5653

Full metadata record

DC FieldValue Language
dc.contributor.authorMocanu, Edgaren
dc.contributor.authorShattock, Richarden
dc.contributor.authorBarton, Daviden
dc.contributor.authorRogers, Melissaen
dc.contributor.authorConroy, Ronanen
dc.contributor.authorSheils, Orlaen
dc.contributor.authorCollins, Claireen
dc.contributor.authorMartin, Caraen
dc.contributor.authorHarrison, Roberten
dc.contributor.authorO'Leary, Johnen
dc.date.accessioned2011-11-18T12:30:37Z-
dc.date.available2011-11-18T12:30:37Z-
dc.date.issued2010-11-
dc.identifier.citationAll azoospermic males should be screened for cystic fibrosis mutations before intracytoplasmic sperm injection. 2010, 94 (6):2448-50 Fertil. Steril.en
dc.identifier.issn1556-5653-
dc.identifier.pmid20381036-
dc.identifier.doi10.1016/j.fertnstert.2010.02.029-
dc.identifier.urihttp://hdl.handle.net/10147/189953-
dc.descriptionWe assessed the frequency of CFTR mutations in groups with varying degrees of sub-fertility and compared these groups to a fertile male group with proven paternity. Screening for CFTR mutations should be routine for all azoospermic males, irrespective of obstructive or non-obstructive etiology, prior to proposing ICSI treatment. CFTR testing has no value in the investigation of non-azoospermic infertile males.en
dc.description.abstractWe assessed the frequency of CFTR mutations in groups with varying degrees of sub-fertility and compared these groups to a fertile male group with proven paternity. Screening for CFTR mutations should be routine for all azoospermic males, irrespective of obstructive or non-obstructive etiology, prior to proposing ICSI treatment. CFTR testing has no value in the investigation of non-azoospermic infertile males.-
dc.language.isoenen
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0015028210003080en
dc.subjectFERTILITYen
dc.subject.meshAzoospermia-
dc.subject.meshCase-Control Studies-
dc.subject.meshCystic Fibrosis-
dc.subject.meshCystic Fibrosis Transmembrane Conductance Regulator-
dc.subject.meshDNA Mutational Analysis-
dc.subject.meshGene Frequency-
dc.subject.meshGenetic Testing-
dc.subject.meshHeterozygote Detection-
dc.subject.meshHumans-
dc.subject.meshInfertility, Male-
dc.subject.meshMale-
dc.subject.meshMutation-
dc.subject.meshPredictive Value of Tests-
dc.subject.meshPrognosis-
dc.subject.meshSperm Injections, Intracytoplasmic-
dc.titleAll azoospermic males should be screened for cystic fibrosis mutations before intracytoplasmic sperm injection.en
dc.typeArticleen
dc.contributor.departmentHuman Assisted Reproduction Ireland, Rotunda Hospital, and Royal College of Surgeons in Ireland, Dublin, Ireland. emocanu@rcsi.ieen
dc.identifier.journalFertility and sterilityen
dc.description.provinceLeinster-

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