Following the genes: a framework for animal modeling of psychiatric disorders

Hdl Handle:
http://hdl.handle.net/10147/189669
Title:
Following the genes: a framework for animal modeling of psychiatric disorders
Authors:
Mitchell, Kevin; Huang, Josh; Moghaddam, Bita; Sawa, Akira
Citation:
BMC Biology. 2011 Nov 11;9(1):76
Issue Date:
11-Nov-2011
URI:
http://hdl.handle.net/10147/189669
Abstract:
Abstract The number of individual cases of psychiatric disorders that can be ascribed to identified, rare, single mutations is increasing with great rapidity. Such mutations can be recapitulated in mice to generate animal models with direct etiological validity. Defining the underlying pathogenic mechanisms will require an experimental and theoretical framework to make the links from mutation to altered behavior in an animal or psychopathology in a human. Here, we discuss key elements of such a framework, including cell type-based phenotyping, developmental trajectories, linking circuit properties at micro and macro scales and definition of neurobiological phenotypes that are directly translatable to humans.
Item Type:
Journal Article

Full metadata record

DC FieldValue Language
dc.contributor.authorMitchell, Kevin-
dc.contributor.authorHuang, Josh-
dc.contributor.authorMoghaddam, Bita-
dc.contributor.authorSawa, Akira-
dc.date.accessioned2011-11-15T13:55:24Z-
dc.date.available2011-11-15T13:55:24Z-
dc.date.issued2011-11-11-
dc.identifierhttp://dx.doi.org/10.1186/1741-7007-9-76-
dc.identifier.citationBMC Biology. 2011 Nov 11;9(1):76-
dc.identifier.urihttp://hdl.handle.net/10147/189669-
dc.description.abstractAbstract The number of individual cases of psychiatric disorders that can be ascribed to identified, rare, single mutations is increasing with great rapidity. Such mutations can be recapitulated in mice to generate animal models with direct etiological validity. Defining the underlying pathogenic mechanisms will require an experimental and theoretical framework to make the links from mutation to altered behavior in an animal or psychopathology in a human. Here, we discuss key elements of such a framework, including cell type-based phenotyping, developmental trajectories, linking circuit properties at micro and macro scales and definition of neurobiological phenotypes that are directly translatable to humans.-
dc.titleFollowing the genes: a framework for animal modeling of psychiatric disorders-
dc.typeJournal Article-
dc.language.rfc3066en-
dc.rights.holderMitchell et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2011-11-15T12:19:08Z-
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