The secret life of kinases: functions beyond catalysis.

Hdl Handle:
http://hdl.handle.net/10147/189656
Title:
The secret life of kinases: functions beyond catalysis.
Authors:
Rauch, Jens; Volinsky, Natalia; Romano, David; Kolch, Walter
Citation:
Cell Communication and Signaling. 2011 Oct 28;9(1):23
Issue Date:
28-Oct-2011
URI:
http://hdl.handle.net/10147/189656
Abstract:
Abstract Protein phosphorylation participates in the regulation of all fundamental biological processes, and protein kinases have been intensively studied. However, while the focus was on catalytic activities, accumulating evidence suggests that non-catalytic properties of protein kinases are essential, and in some cases even sufficient for their functions. These non-catalytic functions include the scaffolding of protein complexes, the competition for protein interactions, allosteric effects on other enzymes, subcellular targeting, and DNA binding. This rich repertoire often is used to coordinate phosphorylation events and enhance the specificity of substrate phosphorylation, but also can adopt functions that do not rely on kinase activity. Here, we discuss such kinase independent functions of protein and lipid kinases focussing on kinases that play a role in the regulation of cell proliferation, differentiation, apoptosis, and motility.
Item Type:
Journal Article

Full metadata record

DC FieldValue Language
dc.contributor.authorRauch, Jens-
dc.contributor.authorVolinsky, Natalia-
dc.contributor.authorRomano, David-
dc.contributor.authorKolch, Walter-
dc.date.accessioned2011-11-15T13:56:42Z-
dc.date.available2011-11-15T13:56:42Z-
dc.date.issued2011-10-28-
dc.identifierhttp://dx.doi.org/10.1186/1478-811X-9-23-
dc.identifier.citationCell Communication and Signaling. 2011 Oct 28;9(1):23-
dc.identifier.urihttp://hdl.handle.net/10147/189656-
dc.description.abstractAbstract Protein phosphorylation participates in the regulation of all fundamental biological processes, and protein kinases have been intensively studied. However, while the focus was on catalytic activities, accumulating evidence suggests that non-catalytic properties of protein kinases are essential, and in some cases even sufficient for their functions. These non-catalytic functions include the scaffolding of protein complexes, the competition for protein interactions, allosteric effects on other enzymes, subcellular targeting, and DNA binding. This rich repertoire often is used to coordinate phosphorylation events and enhance the specificity of substrate phosphorylation, but also can adopt functions that do not rely on kinase activity. Here, we discuss such kinase independent functions of protein and lipid kinases focussing on kinases that play a role in the regulation of cell proliferation, differentiation, apoptosis, and motility.-
dc.titleThe secret life of kinases: functions beyond catalysis.-
dc.typeJournal Article-
dc.language.rfc3066en-
dc.rights.holderRauch et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2011-11-15T12:19:51Z-
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