Ethnic differences in lipoprotein subclasses in obese adolescents: importance of liver and intraabdominal fat accretion.

Hdl Handle:
http://hdl.handle.net/10147/188295
Title:
Ethnic differences in lipoprotein subclasses in obese adolescents: importance of liver and intraabdominal fat accretion.
Authors:
D'Adamo, Ebe; Northrup, Veronika; Weiss, Ram; Santoro, Nicola; Pierpont, Bridget; Savoye, Mary; O'Malley, Grace; Caprio, Sonia
Affiliation:
Department of Pediatrics, Yale University, New Haven, CT, USA.
Citation:
Ethnic differences in lipoprotein subclasses in obese adolescents: importance of liver and intraabdominal fat accretion. 2010, 92 (3):500-8 Am. J. Clin. Nutr.
Journal:
The American journal of clinical nutrition
Issue Date:
Sep-2010
URI:
http://hdl.handle.net/10147/188295
DOI:
10.3945/ajcn.2010.29270
PubMed ID:
20573788
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/20573788
Abstract:
Recently, the deleterious metabolic effects of visceral fat [visceral adipose tissue (VAT)] deposition were challenged, and liver fat emerged as having a key independent role in the modulation of cardiometabolic risk factors.; We explored the relation between liver fat content and VAT in 3 ethnic groups and evaluated whether the ethnic differences in the distributions of lipoprotein concentrations and sizes were associated with the hepatic fat fraction (HFF), VAT, or both.; In a multiethnic group of 33 white, 33 African American, and 33 Hispanic obese adolescents with normal glucose tolerance, we measured VAT and HFF by using magnetic resonance imaging. Fasting lipoprotein particle number and size were measured by using nuclear magnetic resonance spectroscopy. To assess the association between VAT and HFF, we categorized VAT into tertiles.; In each ethnic group, HFF values increased between successive tertiles of VAT. After multivariate adjustment and in comparison with the 2 other groups, African Americans showed lower triglyceride (P = 0.001) and higher HDL (P = 0.03) concentrations, lower concentrations of total (P = 0.007), large (P = 0.005), and medium (P lt 0.0001) VLDL, but higher concentrations of large HDL particles (P = 0.01) and larger HDL (P = 0.005). In multivariate linear models, independent of ethnicity, VAT was a significant predictor for large HDL (P = 0.003) and total small LDL (P = 0.001) concentrations, whereas HFF significantly predicted large VLDL (P = 0.03) concentrations.; Liver fat accretion, independent of VAT, may play a role in the ethnic differences seen in large VLDL particles. This trial was registered at clinicaltrials.gov as NCT00536250.
Item Type:
Article In Press
Language:
en
MeSH:
Adolescent; African Americans; Child; European Continental Ancestry Group; Female; Hispanic Americans; Humans; Intra-Abdominal Fat; Lipid Metabolism; Lipoproteins; Liver; Magnetic Resonance Imaging; Male; Obesity; Particle Size; Triglycerides
ISSN:
1938-3207
Sponsors:
Irish Fulbright Commission

Full metadata record

DC FieldValue Language
dc.contributor.authorD'Adamo, Ebeen
dc.contributor.authorNorthrup, Veronikaen
dc.contributor.authorWeiss, Ramen
dc.contributor.authorSantoro, Nicolaen
dc.contributor.authorPierpont, Bridgeten
dc.contributor.authorSavoye, Maryen
dc.contributor.authorO'Malley, Graceen
dc.contributor.authorCaprio, Soniaen
dc.date.accessioned2011-11-01T11:55:09Z-
dc.date.available2011-11-01T11:55:09Z-
dc.date.issued2010-09-
dc.identifier.citationEthnic differences in lipoprotein subclasses in obese adolescents: importance of liver and intraabdominal fat accretion. 2010, 92 (3):500-8 Am. J. Clin. Nutr.en
dc.identifier.issn1938-3207-
dc.identifier.pmid20573788-
dc.identifier.doi10.3945/ajcn.2010.29270-
dc.identifier.urihttp://hdl.handle.net/10147/188295-
dc.description.abstractRecently, the deleterious metabolic effects of visceral fat [visceral adipose tissue (VAT)] deposition were challenged, and liver fat emerged as having a key independent role in the modulation of cardiometabolic risk factors.-
dc.description.abstractWe explored the relation between liver fat content and VAT in 3 ethnic groups and evaluated whether the ethnic differences in the distributions of lipoprotein concentrations and sizes were associated with the hepatic fat fraction (HFF), VAT, or both.-
dc.description.abstractIn a multiethnic group of 33 white, 33 African American, and 33 Hispanic obese adolescents with normal glucose tolerance, we measured VAT and HFF by using magnetic resonance imaging. Fasting lipoprotein particle number and size were measured by using nuclear magnetic resonance spectroscopy. To assess the association between VAT and HFF, we categorized VAT into tertiles.-
dc.description.abstractIn each ethnic group, HFF values increased between successive tertiles of VAT. After multivariate adjustment and in comparison with the 2 other groups, African Americans showed lower triglyceride (P = 0.001) and higher HDL (P = 0.03) concentrations, lower concentrations of total (P = 0.007), large (P = 0.005), and medium (P lt 0.0001) VLDL, but higher concentrations of large HDL particles (P = 0.01) and larger HDL (P = 0.005). In multivariate linear models, independent of ethnicity, VAT was a significant predictor for large HDL (P = 0.003) and total small LDL (P = 0.001) concentrations, whereas HFF significantly predicted large VLDL (P = 0.03) concentrations.-
dc.description.abstractLiver fat accretion, independent of VAT, may play a role in the ethnic differences seen in large VLDL particles. This trial was registered at clinicaltrials.gov as NCT00536250.-
dc.description.sponsorshipIrish Fulbright Commissionen
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/20573788en
dc.subject.meshAdolescent-
dc.subject.meshAfrican Americans-
dc.subject.meshChild-
dc.subject.meshEuropean Continental Ancestry Group-
dc.subject.meshFemale-
dc.subject.meshHispanic Americans-
dc.subject.meshHumans-
dc.subject.meshIntra-Abdominal Fat-
dc.subject.meshLipid Metabolism-
dc.subject.meshLipoproteins-
dc.subject.meshLiver-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshMale-
dc.subject.meshObesity-
dc.subject.meshParticle Size-
dc.subject.meshTriglycerides-
dc.titleEthnic differences in lipoprotein subclasses in obese adolescents: importance of liver and intraabdominal fat accretion.en
dc.typeArticle In Pressen
dc.contributor.departmentDepartment of Pediatrics, Yale University, New Haven, CT, USA.en
dc.identifier.journalThe American journal of clinical nutritionen
dc.description.provinceLeinster-

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