Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis.
Authors
Hogan, A ETobin, A M
Ahern, T
Corrigan, M A
Gaoatswe, G
Jackson, R
O'Reilly, V
Lynch, L
Doherty, D G
Moynagh, P N
Kirby, B
O'Connell, J
O'Shea, D
Affiliation
Department of Endocrinology, St Vincent's University Hospital, University College Dublin, Dublin 4, Ireland.Issue Date
2011-11
Metadata
Show full item recordCitation
Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis. 2011, 54 (11):2745-54 DiabetologiaJournal
DiabetologiaDOI
10.1007/s00125-011-2232-3PubMed ID
21744074Abstract
The innate immune cells, invariant natural killer T cells (iNKT cells), are implicated in the pathogenesis of psoriasis, an inflammatory condition associated with obesity and other metabolic diseases, such as diabetes and dyslipidaemia. We observed an improvement in psoriasis severity in a patient within days of starting treatment with an incretin-mimetic, glucagon-like peptide-1 (GLP-1) receptor agonist. This was independent of change in glycaemic control. We proposed that this unexpected clinical outcome resulted from a direct effect of GLP-1 on iNKT cells.We measured circulating and psoriatic plaque iNKT cell numbers in two patients with type 2 diabetes and psoriasis before and after commencing GLP-1 analogue therapy. In addition, we investigated the in vitro effects of GLP-1 on iNKT cells and looked for a functional GLP-1 receptor on these cells.
The Psoriasis Area and Severity Index improved in both patients following 6 weeks of GLP-1 analogue therapy. This was associated with an alteration in iNKT cell number, with an increased number in the circulation and a decreased number in psoriatic plaques. The GLP-1 receptor was expressed on iNKT cells, and GLP-1 induced a dose-dependent inhibition of iNKT cell cytokine secretion, but not cytolytic degranulation in vitro.
The clinical effect observed and the direct interaction between GLP-1 and the immune system raise the possibility of therapeutic applications for GLP-1 in inflammatory conditions such as psoriasis.
Item Type
ArticleLanguage
enISSN
1432-0428ae974a485f413a2113503eed53cd6c53
10.1007/s00125-011-2232-3
Scopus Count
Collections
Related articles
- Glucagon-like peptide-1 analogue therapy for psoriasis patients with obesity and type 2 diabetes: a prospective cohort study.
- Authors: Ahern T, Tobin AM, Corrigan M, Hogan A, Sweeney C, Kirby B, O'Shea D
- Issue date: 2013 Nov
- Glucagon-like peptide-1 (GLP-1) receptor agonists, obesity and psoriasis: diabetes meets dermatology.
- Authors: Drucker DJ, Rosen CF
- Issue date: 2011 Nov
- Improvement of psoriasis during glucagon-like peptide-1 analogue therapy in type 2 diabetes is associated with decreasing dermal γδ T-cell number: a prospective case-series study.
- Authors: Buysschaert M, Baeck M, Preumont V, Marot L, Hendrickx E, Van Belle A, Dumoutier L
- Issue date: 2014 Jul
- Improvement of psoriasis during exenatide treatment in a patient with diabetes.
- Authors: Buysschaert M, Tennstedt D, Preumont V
- Issue date: 2012 Feb
- Improvement in psoriasis after treatment with the glucagon-like peptide-1 receptor agonist liraglutide.
- Authors: Faurschou A, Knop FK, Thyssen JP, Zachariae C, Skov L, Vilsbøll T
- Issue date: 2014 Feb