First and second trimester sonographic screening for fetal Down syndrome

Hdl Handle:
http://hdl.handle.net/10147/144482
Title:
First and second trimester sonographic screening for fetal Down syndrome
Authors:
Unterscheider, J; Malone, Fergal D
Citation:
First and second trimester sonographic screening for fetal Down syndrome 2011, 22 (01):45 Fetal and Maternal Medicine Review
Publisher:
Cambridge University Press
Journal:
Fetal and Maternal Medicine Review
Issue Date:
Feb-2011
URI:
http://hdl.handle.net/10147/144482
DOI:
10.1017/S0965539511000027
Additional Links:
http://www.journals.cambridge.org/abstract_S0965539511000027
Item Type:
Article
Language:
en
Description:
Screening for Down syndrome is an important part of routine antenatal care and should be made available, if requested, after appropriate counselling including risks and benefits, to all pregnant women, regardless of maternal age. Prenatal screening for fetal Down syndrome and other aneuploidies has advanced significantly since its advent in the 1980s. Historically, women 35 years or older were offered prenatal genetic counselling and the option of a diagnostic test such as chorionic villus sampling or amniocentesis. With this screening approach only 20% to 30% of the fetal Down syndrome population are detected antenatally. Sonographic and maternal biochemical markers are now used in combination to screen for aneuploidies in the first and second trimesters. The most common screening method in the first trimester combines the maternal serum markers HCG and PAPP-A with the sonographic evaluation of fetal nuchal translucency thickness. Newer markers have been proposed to further refine the risk assessment for Down syndrome to maximise detection rates and minimise false positive rates. These newer first trimester markers include sonographic assessment of the fetal nasal bone (NB), the frontomaxillary facial (FMF) angle, ductus venosus (DV) Doppler and tricuspid valve regurgitation (TR).
ISSN:
0965-5395; 1469-5065

Full metadata record

DC FieldValue Language
dc.contributor.authorUnterscheider, Jen
dc.contributor.authorMalone, Fergal Den
dc.date.accessioned2011-10-10T15:21:41Z-
dc.date.available2011-10-10T15:21:41Z-
dc.date.issued2011-02-
dc.identifier.citationFirst and second trimester sonographic screening for fetal Down syndrome 2011, 22 (01):45 Fetal and Maternal Medicine Reviewen
dc.identifier.issn0965-5395-
dc.identifier.issn1469-5065-
dc.identifier.doi10.1017/S0965539511000027-
dc.identifier.urihttp://hdl.handle.net/10147/144482-
dc.descriptionScreening for Down syndrome is an important part of routine antenatal care and should be made available, if requested, after appropriate counselling including risks and benefits, to all pregnant women, regardless of maternal age. Prenatal screening for fetal Down syndrome and other aneuploidies has advanced significantly since its advent in the 1980s. Historically, women 35 years or older were offered prenatal genetic counselling and the option of a diagnostic test such as chorionic villus sampling or amniocentesis. With this screening approach only 20% to 30% of the fetal Down syndrome population are detected antenatally. Sonographic and maternal biochemical markers are now used in combination to screen for aneuploidies in the first and second trimesters. The most common screening method in the first trimester combines the maternal serum markers HCG and PAPP-A with the sonographic evaluation of fetal nuchal translucency thickness. Newer markers have been proposed to further refine the risk assessment for Down syndrome to maximise detection rates and minimise false positive rates. These newer first trimester markers include sonographic assessment of the fetal nasal bone (NB), the frontomaxillary facial (FMF) angle, ductus venosus (DV) Doppler and tricuspid valve regurgitation (TR).en
dc.language.isoenen
dc.publisherCambridge University Pressen
dc.relation.urlhttp://www.journals.cambridge.org/abstract_S0965539511000027en
dc.titleFirst and second trimester sonographic screening for fetal Down syndromeen
dc.typeArticleen
dc.identifier.journalFetal and Maternal Medicine Reviewen
dc.description.provinceLeinster-
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