Should children with inherited metabolic disorders receive varicella vaccination?

Hdl Handle:
http://hdl.handle.net/10147/144297
Title:
Should children with inherited metabolic disorders receive varicella vaccination?
Authors:
Varghese, M; Cafferkey, M; O'Regan, M; Monavari, A A; Treacy, E P
Affiliation:
National Centre for Inherited Metabolic Disorders, Children's University Hospital, Dublin, Ireland.
Citation:
Should children with inherited metabolic disorders receive varicella vaccination? 2011, 96 (1):99-100 Arch. Dis. Child.
Journal:
Archives of disease in childhood
Issue Date:
Jan-2011
URI:
http://hdl.handle.net/10147/144297
DOI:
10.1136/adc.2008.147934
PubMed ID:
19846994
Additional Links:
http://adc.bmj.com/content/96/1/99.long
Abstract:
The aim was to determine the rate of varicella infection and complications in children with disorders of intermediary metabolism (IEM) between the ages of 1 and 16 years attending our national metabolic referral centre. Of 126 children identified, a response was received from 122. A history of previous varicella infection was identified in 64 cases (53%) and of varicella vaccination in 5 (4%). Fifty-three (43%) patients apparently did not have a history of clinical varicella infection. Of the 64 children with a history of varicella infection, five required hospitalisation for complications, including life-threatening lactic acidosis in one patient with mitochondrial disease and metabolic decompensation in four patients. In conclusion, varicella infection may cause an increased risk of metabolic decompensation in patients with IEMs. We propose that a trial of varicella vaccination be considered for this cohort of patients with monitoring of its safety and efficacy.
Item Type:
Article
Language:
en
Description:
The aim was to determine the rate of varicella infection and complications in children with disorders of intermediary metabolism (IEM) between the ages of 1 and 16 years attending our national metabolic referral centre. Of 126 children identified, a response was received from 122. A history of previous varicella infection was identified in 64 cases (53%) and of varicella vaccination in 5 (4%). Fifty-three (43%) patients apparently did not have a history of clinical varicella infection. Of the 64 children with a history of varicella infection, five required hospitalisation for complications, including life-threatening lactic acidosis in one patient with mitochondrial disease and metabolic decompensation in four patients. In conclusion, varicella infection may cause an increased risk of metabolic decompensation in patients with IEMs. We propose that a trial of varicella vaccination be considered for this cohort of patients with monitoring of its safety and efficacy.
MeSH:
Adolescent; Chickenpox; Chickenpox Vaccine; Child; Child, Preschool; Hospitalization; Humans; Infant; Ireland; Metabolism, Inborn Errors; Vaccination
ISSN:
1468-2044

Full metadata record

DC FieldValue Language
dc.contributor.authorVarghese, Men
dc.contributor.authorCafferkey, Men
dc.contributor.authorO'Regan, Men
dc.contributor.authorMonavari, A Aen
dc.contributor.authorTreacy, E Pen
dc.date.accessioned2011-10-07T14:05:10Z-
dc.date.available2011-10-07T14:05:10Z-
dc.date.issued2011-01-
dc.identifier.citationShould children with inherited metabolic disorders receive varicella vaccination? 2011, 96 (1):99-100 Arch. Dis. Child.en
dc.identifier.issn1468-2044-
dc.identifier.pmid19846994-
dc.identifier.doi10.1136/adc.2008.147934-
dc.identifier.urihttp://hdl.handle.net/10147/144297-
dc.descriptionThe aim was to determine the rate of varicella infection and complications in children with disorders of intermediary metabolism (IEM) between the ages of 1 and 16 years attending our national metabolic referral centre. Of 126 children identified, a response was received from 122. A history of previous varicella infection was identified in 64 cases (53%) and of varicella vaccination in 5 (4%). Fifty-three (43%) patients apparently did not have a history of clinical varicella infection. Of the 64 children with a history of varicella infection, five required hospitalisation for complications, including life-threatening lactic acidosis in one patient with mitochondrial disease and metabolic decompensation in four patients. In conclusion, varicella infection may cause an increased risk of metabolic decompensation in patients with IEMs. We propose that a trial of varicella vaccination be considered for this cohort of patients with monitoring of its safety and efficacy.en
dc.description.abstractThe aim was to determine the rate of varicella infection and complications in children with disorders of intermediary metabolism (IEM) between the ages of 1 and 16 years attending our national metabolic referral centre. Of 126 children identified, a response was received from 122. A history of previous varicella infection was identified in 64 cases (53%) and of varicella vaccination in 5 (4%). Fifty-three (43%) patients apparently did not have a history of clinical varicella infection. Of the 64 children with a history of varicella infection, five required hospitalisation for complications, including life-threatening lactic acidosis in one patient with mitochondrial disease and metabolic decompensation in four patients. In conclusion, varicella infection may cause an increased risk of metabolic decompensation in patients with IEMs. We propose that a trial of varicella vaccination be considered for this cohort of patients with monitoring of its safety and efficacy.-
dc.language.isoenen
dc.relation.urlhttp://adc.bmj.com/content/96/1/99.longen
dc.subject.meshAdolescent-
dc.subject.meshChickenpox-
dc.subject.meshChickenpox Vaccine-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshHospitalization-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshIreland-
dc.subject.meshMetabolism, Inborn Errors-
dc.subject.meshVaccination-
dc.titleShould children with inherited metabolic disorders receive varicella vaccination?en
dc.typeArticleen
dc.contributor.departmentNational Centre for Inherited Metabolic Disorders, Children's University Hospital, Dublin, Ireland.en
dc.identifier.journalArchives of disease in childhooden
dc.description.provinceLeinster-

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