Utility of therapeutic drug monitoring in the management of HIV-infected pregnant women in receipt of lopinavir.

Hdl Handle:
http://hdl.handle.net/10147/144283
Title:
Utility of therapeutic drug monitoring in the management of HIV-infected pregnant women in receipt of lopinavir.
Authors:
Caswell, R J; Phillips, D; Chaponda, M; Khoo, S H; Taylor, G P; Ghanem, M; Poulton, M; Welch, J; Gibbons, S; Jackson, V; Lambert, J S
Affiliation:
Department of GU Medicine and Teaching Primary Care Trust, Coventry PCT, Coventry.
Citation:
Utility of therapeutic drug monitoring in the management of HIV-infected pregnant women in receipt of lopinavir. 2011, 22 (1):11-4 Int J STD AIDS
Journal:
International journal of STD & AIDS
Issue Date:
Jan-2011
URI:
http://hdl.handle.net/10147/144283
DOI:
10.1258/ijsa.2009.009184
PubMed ID:
21364060
Additional Links:
http://ijsa.rsmjournals.com/content/22/1/11.long
Abstract:
The pharmacokinetics of antiretroviral drugs in pregnancy is poorly understood. We reviewed the use of therapeutic drug monitoring (TDM) in clinical settings to document plasma concentrations of lopinavir during pregnancy and investigated how clinicians acted upon TDM results. A retrospective review was carried out of all HIV-infected pregnant women taking boosted lopinavir-based highly active antiretroviral therapy (HAART) at five National Health Service (NHS) centres in the UK between May 2004 and March 2007. Seventy-three women in receipt of lopinavir were identified, of whom 89% had plasma lopinavir concentrations above the suggested minimum recommended for wild-type HIV. Initial TDM results prompted dosage change in 10% and assessment of adherence and/or pharmacist review in 11%. TDM was repeated in 29%. TDM can play an important role in the clinical management of HIV-positive pregnant women, allowing informed dose modification and an alternative measure of adherence.
Item Type:
Article
Language:
en
Description:
The pharmacokinetics of antiretroviral drugs in pregnancy is poorly understood. We reviewed the use of therapeutic drug monitoring (TDM) in clinical settings to document plasma concentrations of lopinavir during pregnancy and investigated how clinicians acted upon TDM results. A retrospective review was carried out of all HIV-infected pregnant women taking boosted lopinavir-based highly active antiretroviral therapy (HAART) at five National Health Service (NHS) centres in the UK between May 2004 and March 2007. Seventy-three women in receipt of lopinavir were identified, of whom 89% had plasma lopinavir concentrations above the suggested minimum recommended for wild-type HIV. Initial TDM results prompted dosage change in 10% and assessment of adherence and/or pharmacist review in 11%. TDM was repeated in 29%. TDM can play an important role in the clinical management of HIV-positive pregnant women, allowing informed dose modification and an alternative measure of adherence.
MeSH:
Adolescent; Adult; Anti-HIV Agents; Drug Monitoring; Female; Great Britain; HIV Infections; Humans; Plasma; Pregnancy; Pregnancy Complications, Infectious; Pyrimidinones; Retrospective Studies; Treatment Outcome; Young Adult
ISSN:
1758-1052

Full metadata record

DC FieldValue Language
dc.contributor.authorCaswell, R Jen
dc.contributor.authorPhillips, Den
dc.contributor.authorChaponda, Men
dc.contributor.authorKhoo, S Hen
dc.contributor.authorTaylor, G Pen
dc.contributor.authorGhanem, Men
dc.contributor.authorPoulton, Men
dc.contributor.authorWelch, Jen
dc.contributor.authorGibbons, Sen
dc.contributor.authorJackson, Ven
dc.contributor.authorLambert, J Sen
dc.date.accessioned2011-10-07T14:15:20Z-
dc.date.available2011-10-07T14:15:20Z-
dc.date.issued2011-01-
dc.identifier.citationUtility of therapeutic drug monitoring in the management of HIV-infected pregnant women in receipt of lopinavir. 2011, 22 (1):11-4 Int J STD AIDSen
dc.identifier.issn1758-1052-
dc.identifier.pmid21364060-
dc.identifier.doi10.1258/ijsa.2009.009184-
dc.identifier.urihttp://hdl.handle.net/10147/144283-
dc.descriptionThe pharmacokinetics of antiretroviral drugs in pregnancy is poorly understood. We reviewed the use of therapeutic drug monitoring (TDM) in clinical settings to document plasma concentrations of lopinavir during pregnancy and investigated how clinicians acted upon TDM results. A retrospective review was carried out of all HIV-infected pregnant women taking boosted lopinavir-based highly active antiretroviral therapy (HAART) at five National Health Service (NHS) centres in the UK between May 2004 and March 2007. Seventy-three women in receipt of lopinavir were identified, of whom 89% had plasma lopinavir concentrations above the suggested minimum recommended for wild-type HIV. Initial TDM results prompted dosage change in 10% and assessment of adherence and/or pharmacist review in 11%. TDM was repeated in 29%. TDM can play an important role in the clinical management of HIV-positive pregnant women, allowing informed dose modification and an alternative measure of adherence.en
dc.description.abstractThe pharmacokinetics of antiretroviral drugs in pregnancy is poorly understood. We reviewed the use of therapeutic drug monitoring (TDM) in clinical settings to document plasma concentrations of lopinavir during pregnancy and investigated how clinicians acted upon TDM results. A retrospective review was carried out of all HIV-infected pregnant women taking boosted lopinavir-based highly active antiretroviral therapy (HAART) at five National Health Service (NHS) centres in the UK between May 2004 and March 2007. Seventy-three women in receipt of lopinavir were identified, of whom 89% had plasma lopinavir concentrations above the suggested minimum recommended for wild-type HIV. Initial TDM results prompted dosage change in 10% and assessment of adherence and/or pharmacist review in 11%. TDM was repeated in 29%. TDM can play an important role in the clinical management of HIV-positive pregnant women, allowing informed dose modification and an alternative measure of adherence.-
dc.language.isoenen
dc.relation.urlhttp://ijsa.rsmjournals.com/content/22/1/11.longen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAnti-HIV Agents-
dc.subject.meshDrug Monitoring-
dc.subject.meshFemale-
dc.subject.meshGreat Britain-
dc.subject.meshHIV Infections-
dc.subject.meshHumans-
dc.subject.meshPlasma-
dc.subject.meshPregnancy-
dc.subject.meshPregnancy Complications, Infectious-
dc.subject.meshPyrimidinones-
dc.subject.meshRetrospective Studies-
dc.subject.meshTreatment Outcome-
dc.subject.meshYoung Adult-
dc.titleUtility of therapeutic drug monitoring in the management of HIV-infected pregnant women in receipt of lopinavir.en
dc.typeArticleen
dc.contributor.departmentDepartment of GU Medicine and Teaching Primary Care Trust, Coventry PCT, Coventry.en
dc.identifier.journalInternational journal of STD & AIDSen
dc.description.provinceLeinster-

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