Digital mammography in a screening programme and its implications for pathology: a comparative study.

Hdl Handle:
http://hdl.handle.net/10147/141071
Title:
Digital mammography in a screening programme and its implications for pathology: a comparative study.
Authors:
Feeley, Linda; Kiernan, Donal; Mooney, Therese; Flanagan, Fidelma; Hargaden, Gormlaith; Kell, Malcolm; Stokes, Maurice; Kennedy, Margaret
Affiliation:
Department of Histopathology, Mater Misericordiae University Hospital, Eccles Street, Dublin, Ireland. lindafeeley@yahoo.co.uk
Citation:
Digital mammography in a screening programme and its implications for pathology: a comparative study. 2011, 64 (3):215-9 J. Clin. Pathol.
Journal:
Journal of clinical pathology
Issue Date:
Mar-2011
URI:
http://hdl.handle.net/10147/141071
DOI:
10.1136/jcp.2010.085860
PubMed ID:
21177749
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/21177749
Abstract:
Most studies comparing full-field digital mammography (FFDM) with conventional screen-film mammography (SFM) have been radiology-based. The pathological implications of FFDM have received little attention in the literature, especially in the context of screening programmes. The primary objective of this retrospective study is to compare FFDM with SFM in a population-based screening programme with regard to a number of pathological parameters.; During the study period, 107 818 women underwent screening mammograms with almost equal numbers obtained with each technique (49.9% with SFM vs 50.1% with FFDM). We compared SFM with FFDM using the following parameters: recall rate, diagnostic core biopsy rate, cancer detection rates, B3 rate, B4 rate, preoperative diagnostic rate for malignancy, positive predictive values and tumour characteristics.; The recall rate was significantly higher with FFDM (4.21% vs 3.52%, p<0.0001). The overall cancer detection rate of 7.2 per 1000 women screened with FFDM was also significantly higher than the rate of 6.2 per 1000 women screened with SFM (p=0.04). The B3 rate in the SFM group was 1.3 per 1000 women screened versus 2.5 per 1000 women screened in the FFDM group (p<0.001). The recall rate and cancer detection rates (overall, invasive and pure ductal carcinoma in situ) were all significantly higher with FFDM for lesions presenting as microcalcifications.; The higher cancer detection rate with FFDM in this study was due to improved detection of microcalcifications. However, this was achieved at the cost of a higher recall rate and a higher B3 rate, indicating that overtreatment may be problematic with digital mammography.
Item Type:
Article
Language:
en
MeSH:
Biopsy; Breast Neoplasms; Calcinosis; Early Detection of Cancer; Female; Humans; Ireland; Mammography; Middle Aged; Predictive Value of Tests; Radiographic Image Enhancement; Retrospective Studies; X-Ray Intensifying Screens
ISSN:
1472-4146

Full metadata record

DC FieldValue Language
dc.contributor.authorFeeley, Lindaen
dc.contributor.authorKiernan, Donalen
dc.contributor.authorMooney, Thereseen
dc.contributor.authorFlanagan, Fidelmaen
dc.contributor.authorHargaden, Gormlaithen
dc.contributor.authorKell, Malcolmen
dc.contributor.authorStokes, Mauriceen
dc.contributor.authorKennedy, Margareten
dc.date.accessioned2011-08-29T10:19:07Z-
dc.date.available2011-08-29T10:19:07Z-
dc.date.issued2011-03-
dc.identifier.citationDigital mammography in a screening programme and its implications for pathology: a comparative study. 2011, 64 (3):215-9 J. Clin. Pathol.en
dc.identifier.issn1472-4146-
dc.identifier.pmid21177749-
dc.identifier.doi10.1136/jcp.2010.085860-
dc.identifier.urihttp://hdl.handle.net/10147/141071-
dc.description.abstractMost studies comparing full-field digital mammography (FFDM) with conventional screen-film mammography (SFM) have been radiology-based. The pathological implications of FFDM have received little attention in the literature, especially in the context of screening programmes. The primary objective of this retrospective study is to compare FFDM with SFM in a population-based screening programme with regard to a number of pathological parameters.-
dc.description.abstractDuring the study period, 107 818 women underwent screening mammograms with almost equal numbers obtained with each technique (49.9% with SFM vs 50.1% with FFDM). We compared SFM with FFDM using the following parameters: recall rate, diagnostic core biopsy rate, cancer detection rates, B3 rate, B4 rate, preoperative diagnostic rate for malignancy, positive predictive values and tumour characteristics.-
dc.description.abstractThe recall rate was significantly higher with FFDM (4.21% vs 3.52%, p<0.0001). The overall cancer detection rate of 7.2 per 1000 women screened with FFDM was also significantly higher than the rate of 6.2 per 1000 women screened with SFM (p=0.04). The B3 rate in the SFM group was 1.3 per 1000 women screened versus 2.5 per 1000 women screened in the FFDM group (p<0.001). The recall rate and cancer detection rates (overall, invasive and pure ductal carcinoma in situ) were all significantly higher with FFDM for lesions presenting as microcalcifications.-
dc.description.abstractThe higher cancer detection rate with FFDM in this study was due to improved detection of microcalcifications. However, this was achieved at the cost of a higher recall rate and a higher B3 rate, indicating that overtreatment may be problematic with digital mammography.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21177749en
dc.subject.meshBiopsy-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCalcinosis-
dc.subject.meshEarly Detection of Cancer-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIreland-
dc.subject.meshMammography-
dc.subject.meshMiddle Aged-
dc.subject.meshPredictive Value of Tests-
dc.subject.meshRadiographic Image Enhancement-
dc.subject.meshRetrospective Studies-
dc.subject.meshX-Ray Intensifying Screens-
dc.titleDigital mammography in a screening programme and its implications for pathology: a comparative study.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Mater Misericordiae University Hospital, Eccles Street, Dublin, Ireland. lindafeeley@yahoo.co.uken
dc.identifier.journalJournal of clinical pathologyen
dc.description.provinceLeinster-

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