Non-genomic actions of aldosterone: From receptors and signals to membrane targets.

Hdl Handle:
http://hdl.handle.net/10147/141035
Title:
Non-genomic actions of aldosterone: From receptors and signals to membrane targets.
Authors:
Dooley, Ruth; Harvey, Brian J; Thomas, Warren
Affiliation:
Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.
Citation:
Non-genomic actions of aldosterone: From receptors and signals to membrane targets. 2011:notMol Cell Endocrinol
Journal:
Molecular and cellular endocrinology
Issue Date:
26-Jul-2011
URI:
http://hdl.handle.net/10147/141035
DOI:
10.1016/j.mce.2011.07.019
PubMed ID:
21801805
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/21801805
Abstract:
In tissues which express the mineralocorticoid receptor (MR), aldosterone modulates the expression of membrane targets such as the subunits of the epithelial Na(+) channel, in combination with important signalling intermediates such as serum and glucocorticoid-regulated kinase-1. In addition, the rapid 'non-genomic' activation of protein kinases and secondary messenger signalling cascades has also been detected in aldosterone-sensitive tissues of the nephron, distal colon and cardiovascular system. These rapid actions are variously described as being coupled to MR or to an as yet unidentified, membrane-associated aldosterone receptor. The rapidly activated signalling cascades add a level of fine-tuning to the activity of aldosterone-responsive membrane transporters and also modulate the aldosterone-induced changes in gene expression through receptor and transcription factor phosphorylation.
Item Type:
Article
Language:
en
ISSN:
1872-8057

Full metadata record

DC FieldValue Language
dc.contributor.authorDooley, Ruthen
dc.contributor.authorHarvey, Brian Jen
dc.contributor.authorThomas, Warrenen
dc.date.accessioned2011-08-29T09:12:35Z-
dc.date.available2011-08-29T09:12:35Z-
dc.date.issued2011-07-26-
dc.identifier.citationNon-genomic actions of aldosterone: From receptors and signals to membrane targets. 2011:notMol Cell Endocrinolen
dc.identifier.issn1872-8057-
dc.identifier.pmid21801805-
dc.identifier.doi10.1016/j.mce.2011.07.019-
dc.identifier.urihttp://hdl.handle.net/10147/141035-
dc.description.abstractIn tissues which express the mineralocorticoid receptor (MR), aldosterone modulates the expression of membrane targets such as the subunits of the epithelial Na(+) channel, in combination with important signalling intermediates such as serum and glucocorticoid-regulated kinase-1. In addition, the rapid 'non-genomic' activation of protein kinases and secondary messenger signalling cascades has also been detected in aldosterone-sensitive tissues of the nephron, distal colon and cardiovascular system. These rapid actions are variously described as being coupled to MR or to an as yet unidentified, membrane-associated aldosterone receptor. The rapidly activated signalling cascades add a level of fine-tuning to the activity of aldosterone-responsive membrane transporters and also modulate the aldosterone-induced changes in gene expression through receptor and transcription factor phosphorylation.-
dc.languageENG-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21801805en
dc.titleNon-genomic actions of aldosterone: From receptors and signals to membrane targets.en
dc.typeArticleen
dc.contributor.departmentDepartment of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.en
dc.identifier.journalMolecular and cellular endocrinologyen
dc.description.provinceLeinster-

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