Radiotherapy and breast reconstruction: a meta-analysis.

Hdl Handle:
http://hdl.handle.net/10147/139343
Title:
Radiotherapy and breast reconstruction: a meta-analysis.
Authors:
Barry, M; Kell, M R
Affiliation:
Department of Breast Surgery, BreastCheck, Mater Misericordiae University Hospital, Dublin, Ireland.
Citation:
Radiotherapy and breast reconstruction: a meta-analysis. 2011, 127 (1):15-22 Breast Cancer Res. Treat.
Journal:
Breast cancer research and treatment
Issue Date:
May-2011
URI:
http://hdl.handle.net/10147/139343
DOI:
10.1007/s10549-011-1401-x
PubMed ID:
21336948
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/21336948
Abstract:
The optimum sequencing of breast reconstruction (BR) in patients receiving postmastectomy radiation therapy (PMRT) is controversial. A comprehensive search of published studies that examined postoperative morbidity following immediate or delayed BR with combined radiotherapy was performed. Medical (MEDLINE & EMBASE) databases were searched and cross-referenced for appropriate studies where morbidity following BR was the primary outcome measured. A total of 1,105 patients were identified from 11 appropriately selected studies. Patients undergoing PMRT and BR are more likely to suffer morbidity compared with patients not receiving PMRT (OR = 4.2; 95% CI, 2.4-7.2 [no PMRT vs. PMRT]). Reconstruction technique was also examined with outcome when PMRT was delivered after BR, and this demonstrated that autologous reconstruction is associated with less morbidity in this setting (OR = 0.21; 95% CI, 0.1-0.4 [autologous vs. implant-based]). Delaying BR until after PMRT had no significant effect on outcome (OR = 0.87; 95% CI, 0.47-1.62 [delayed vs. immediate]). PMRT has a detrimental effect on BR outcome. These results suggest that where immediate reconstruction is undertaken with the necessity of PMRT, an autologous flap results in less morbidity when compared with implant-based reconstruction.
Item Type:
Article
Language:
en
MeSH:
Breast Neoplasms; Female; Humans; Mammaplasty; Postoperative Period; Treatment Outcome
ISSN:
1573-7217

Full metadata record

DC FieldValue Language
dc.contributor.authorBarry, Men
dc.contributor.authorKell, M Ren
dc.date.accessioned2011-08-10T15:42:07Z-
dc.date.available2011-08-10T15:42:07Z-
dc.date.issued2011-05-
dc.identifier.citationRadiotherapy and breast reconstruction: a meta-analysis. 2011, 127 (1):15-22 Breast Cancer Res. Treat.en
dc.identifier.issn1573-7217-
dc.identifier.pmid21336948-
dc.identifier.doi10.1007/s10549-011-1401-x-
dc.identifier.urihttp://hdl.handle.net/10147/139343-
dc.description.abstractThe optimum sequencing of breast reconstruction (BR) in patients receiving postmastectomy radiation therapy (PMRT) is controversial. A comprehensive search of published studies that examined postoperative morbidity following immediate or delayed BR with combined radiotherapy was performed. Medical (MEDLINE & EMBASE) databases were searched and cross-referenced for appropriate studies where morbidity following BR was the primary outcome measured. A total of 1,105 patients were identified from 11 appropriately selected studies. Patients undergoing PMRT and BR are more likely to suffer morbidity compared with patients not receiving PMRT (OR = 4.2; 95% CI, 2.4-7.2 [no PMRT vs. PMRT]). Reconstruction technique was also examined with outcome when PMRT was delivered after BR, and this demonstrated that autologous reconstruction is associated with less morbidity in this setting (OR = 0.21; 95% CI, 0.1-0.4 [autologous vs. implant-based]). Delaying BR until after PMRT had no significant effect on outcome (OR = 0.87; 95% CI, 0.47-1.62 [delayed vs. immediate]). PMRT has a detrimental effect on BR outcome. These results suggest that where immediate reconstruction is undertaken with the necessity of PMRT, an autologous flap results in less morbidity when compared with implant-based reconstruction.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21336948en
dc.subject.meshBreast Neoplasms-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMammaplasty-
dc.subject.meshPostoperative Period-
dc.subject.meshTreatment Outcome-
dc.titleRadiotherapy and breast reconstruction: a meta-analysis.en
dc.typeArticleen
dc.contributor.departmentDepartment of Breast Surgery, BreastCheck, Mater Misericordiae University Hospital, Dublin, Ireland.en
dc.identifier.journalBreast cancer research and treatmenten
dc.description.provinceLeinster-

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.