Affiliation
Department of Breast Surgery, BreastCheck, Mater Misericordiae University Hospital, Dublin, Ireland.Issue Date
2011-05MeSH
Breast NeoplasmsFemale
Humans
Mammaplasty
Postoperative Period
Treatment Outcome
Metadata
Show full item recordCitation
Radiotherapy and breast reconstruction: a meta-analysis. 2011, 127 (1):15-22 Breast Cancer Res. Treat.Journal
Breast cancer research and treatmentDOI
10.1007/s10549-011-1401-xPubMed ID
21336948Additional Links
http://www.ncbi.nlm.nih.gov/pubmed/21336948Abstract
The optimum sequencing of breast reconstruction (BR) in patients receiving postmastectomy radiation therapy (PMRT) is controversial. A comprehensive search of published studies that examined postoperative morbidity following immediate or delayed BR with combined radiotherapy was performed. Medical (MEDLINE & EMBASE) databases were searched and cross-referenced for appropriate studies where morbidity following BR was the primary outcome measured. A total of 1,105 patients were identified from 11 appropriately selected studies. Patients undergoing PMRT and BR are more likely to suffer morbidity compared with patients not receiving PMRT (OR = 4.2; 95% CI, 2.4-7.2 [no PMRT vs. PMRT]). Reconstruction technique was also examined with outcome when PMRT was delivered after BR, and this demonstrated that autologous reconstruction is associated with less morbidity in this setting (OR = 0.21; 95% CI, 0.1-0.4 [autologous vs. implant-based]). Delaying BR until after PMRT had no significant effect on outcome (OR = 0.87; 95% CI, 0.47-1.62 [delayed vs. immediate]). PMRT has a detrimental effect on BR outcome. These results suggest that where immediate reconstruction is undertaken with the necessity of PMRT, an autologous flap results in less morbidity when compared with implant-based reconstruction.Item Type
ArticleLanguage
enISSN
1573-7217ae974a485f413a2113503eed53cd6c53
10.1007/s10549-011-1401-x
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