Aldosterone-induced signalling and cation transport in the distal nephron.

Hdl Handle:
http://hdl.handle.net/10147/136798
Title:
Aldosterone-induced signalling and cation transport in the distal nephron.
Authors:
Thomas, Warren; McEneaney, Victoria; Harvey, Brian J
Affiliation:
Department of Molecular Medicine, Royal College of Surgeons in Ireland Education and Research Centre, Beaumont Hospital, Dublin, Ireland. wthomas@rcsi.ie
Citation:
Aldosterone-induced signalling and cation transport in the distal nephron. 2008, 73 (9-10):979-84 Steroids
Journal:
Steroids
Issue Date:
Oct-2008
URI:
http://hdl.handle.net/10147/136798
DOI:
10.1016/j.steroids.2008.01.013
PubMed ID:
18308353
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/18308353
Abstract:
Aldosterone is an important regulator of Na(+) and K(+) transport in the distal nephron modulating the surface expression of transporters through the action of the mineralocorticoid receptor as a ligand-dependent transcription factor. Aldosterone stimulates the rapid activation of protein kinase-based signalling cascades that modulate the genomic effects of the hormone. Evidence is accumulating about the multi-factorial regulation of the epithelial sodium channel (ENaC) by aldosterone. Recent published data suggests that the activation of a novel PKC/PKD signalling pathway through the c-Src-dependent trans-activation of epidermal growth factor receptor contributes to early ENaC trafficking in response to aldosterone.
Item Type:
Article
Language:
en
MeSH:
Aldosterone; Animals; Biological Transport; Cations; Cell Communication; Enzyme Activation; Epidermal Growth Factor; Humans; Ion Transport; Models, Biological; Nephrons; Potassium; Protein Kinases; Signal Transduction; Transcriptional Activation
ISSN:
0039-128X

Full metadata record

DC FieldValue Language
dc.contributor.authorThomas, Warrenen
dc.contributor.authorMcEneaney, Victoriaen
dc.contributor.authorHarvey, Brian Jen
dc.date.accessioned2011-07-25T08:38:21Z-
dc.date.available2011-07-25T08:38:21Z-
dc.date.issued2008-10-
dc.identifier.citationAldosterone-induced signalling and cation transport in the distal nephron. 2008, 73 (9-10):979-84 Steroidsen
dc.identifier.issn0039-128X-
dc.identifier.pmid18308353-
dc.identifier.doi10.1016/j.steroids.2008.01.013-
dc.identifier.urihttp://hdl.handle.net/10147/136798-
dc.description.abstractAldosterone is an important regulator of Na(+) and K(+) transport in the distal nephron modulating the surface expression of transporters through the action of the mineralocorticoid receptor as a ligand-dependent transcription factor. Aldosterone stimulates the rapid activation of protein kinase-based signalling cascades that modulate the genomic effects of the hormone. Evidence is accumulating about the multi-factorial regulation of the epithelial sodium channel (ENaC) by aldosterone. Recent published data suggests that the activation of a novel PKC/PKD signalling pathway through the c-Src-dependent trans-activation of epidermal growth factor receptor contributes to early ENaC trafficking in response to aldosterone.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/18308353en
dc.subject.meshAldosterone-
dc.subject.meshAnimals-
dc.subject.meshBiological Transport-
dc.subject.meshCations-
dc.subject.meshCell Communication-
dc.subject.meshEnzyme Activation-
dc.subject.meshEpidermal Growth Factor-
dc.subject.meshHumans-
dc.subject.meshIon Transport-
dc.subject.meshModels, Biological-
dc.subject.meshNephrons-
dc.subject.meshPotassium-
dc.subject.meshProtein Kinases-
dc.subject.meshSignal Transduction-
dc.subject.meshTranscriptional Activation-
dc.titleAldosterone-induced signalling and cation transport in the distal nephron.en
dc.typeArticleen
dc.contributor.departmentDepartment of Molecular Medicine, Royal College of Surgeons in Ireland Education and Research Centre, Beaumont Hospital, Dublin, Ireland. wthomas@rcsi.ieen
dc.identifier.journalSteroidsen
dc.description.provinceLeinster-

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