Aplastic anaemia preceding acute lymphoblastic leukaemia in an adult with isolated deletion of chromosome 9q.

Hdl Handle:
http://hdl.handle.net/10147/136796
Title:
Aplastic anaemia preceding acute lymphoblastic leukaemia in an adult with isolated deletion of chromosome 9q.
Authors:
Kelly, Kevin; Murphy, Philip
Affiliation:
Department of Haematology, Beaumont Hospital, Dublin, Ireland. kevrkelly77@hotmail.com
Citation:
Aplastic anaemia preceding acute lymphoblastic leukaemia in an adult with isolated deletion of chromosome 9q. 2008, 32 (12):1936-8 Leuk. Res.
Journal:
Leukemia research
Issue Date:
Dec-2008
URI:
http://hdl.handle.net/10147/136796
DOI:
10.1016/j.leukres.2008.03.012
PubMed ID:
18490054
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/18490054
Abstract:
Aplastic anaemia (AA) can precede acute lymphoblastic leukaemia (ALL) in 2% of children but this is rarely reported to occur in adults. A 21-year-old male presented with bone marrow failure and bone marrow biopsy showed a profoundly hypocellular marrow. He recovered spontaneously but represented 2 months later when he was diagnosed with pre-B acute lymphoblastic leukaemia. Chromosomal examination revealed 46,XY,del(9)(q13q34). To the best of our knowledge this is the first case to be reported of aplasia preceding ALL with 9q minus as the sole chromosomal abnormality.
Item Type:
Article
Language:
en
MeSH:
Anemia, Aplastic; Blast Crisis; Bone Marrow; Chromosome Deletion; Chromosomes, Human, Pair 9; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult
ISSN:
0145-2126

Full metadata record

DC FieldValue Language
dc.contributor.authorKelly, Kevinen
dc.contributor.authorMurphy, Philipen
dc.date.accessioned2011-07-25T08:37:07Z-
dc.date.available2011-07-25T08:37:07Z-
dc.date.issued2008-12-
dc.identifier.citationAplastic anaemia preceding acute lymphoblastic leukaemia in an adult with isolated deletion of chromosome 9q. 2008, 32 (12):1936-8 Leuk. Res.en
dc.identifier.issn0145-2126-
dc.identifier.pmid18490054-
dc.identifier.doi10.1016/j.leukres.2008.03.012-
dc.identifier.urihttp://hdl.handle.net/10147/136796-
dc.description.abstractAplastic anaemia (AA) can precede acute lymphoblastic leukaemia (ALL) in 2% of children but this is rarely reported to occur in adults. A 21-year-old male presented with bone marrow failure and bone marrow biopsy showed a profoundly hypocellular marrow. He recovered spontaneously but represented 2 months later when he was diagnosed with pre-B acute lymphoblastic leukaemia. Chromosomal examination revealed 46,XY,del(9)(q13q34). To the best of our knowledge this is the first case to be reported of aplasia preceding ALL with 9q minus as the sole chromosomal abnormality.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/18490054en
dc.subject.meshAnemia, Aplastic-
dc.subject.meshBlast Crisis-
dc.subject.meshBone Marrow-
dc.subject.meshChromosome Deletion-
dc.subject.meshChromosomes, Human, Pair 9-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma-
dc.subject.meshYoung Adult-
dc.titleAplastic anaemia preceding acute lymphoblastic leukaemia in an adult with isolated deletion of chromosome 9q.en
dc.typeArticleen
dc.contributor.departmentDepartment of Haematology, Beaumont Hospital, Dublin, Ireland. kevrkelly77@hotmail.comen
dc.identifier.journalLeukemia researchen
dc.description.provinceLeinster-

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