Direct binding and activation of protein kinase C isoforms by steroid hormones.

Hdl Handle:
http://hdl.handle.net/10147/136787
Title:
Direct binding and activation of protein kinase C isoforms by steroid hormones.
Authors:
Alzamora, Rodrigo; Harvey, Brian J
Affiliation:
Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Smurfit Building, Beaumont Hospital PO Box 9063, Dublin 9, Ireland. AlzamoraR@dom.pitt.edu
Citation:
Direct binding and activation of protein kinase C isoforms by steroid hormones. 2008, 73 (9-10):885-8 Steroids
Journal:
Steroids
Issue Date:
Oct-2008
URI:
http://hdl.handle.net/10147/136787
DOI:
10.1016/j.steroids.2008.01.001
PubMed ID:
18329060
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/18329060
Abstract:
The non-genomic action of steroid hormones regulates a wide variety of cellular responses including regulation of ion transport, cell proliferation, migration, death and differentiation. In order to achieve such plethora of effects steroid hormones utilize nearly all known signal transduction pathways. One of the key signalling molecules regulating the non-genomic action of steroid hormones is protein kinase C (PKC). It is thought that rapid action of steroids hormones results from the activation of plasma membrane receptors; however, their molecular identity remains elusive. In recent years, an increasing number of studies have pointed at the selective binding and activation of specific PKC isoforms by steroid hormones. This has led to the hypothesis that PKC could act as a receptor as well as a transducer of the non-genomic effects of these hormones. In this review we summarize the current knowledge of the direct binding and activation of PKC by steroid hormones.
Item Type:
Article
Language:
en
MeSH:
Aldosterone; Animals; Binding Sites; Estradiol; Humans; Models, Biological; Mutation; Protein Binding; Protein Isoforms; Protein Kinase C; Steroids
ISSN:
0039-128X

Full metadata record

DC FieldValue Language
dc.contributor.authorAlzamora, Rodrigoen
dc.contributor.authorHarvey, Brian Jen
dc.date.accessioned2011-07-25T08:38:07Z-
dc.date.available2011-07-25T08:38:07Z-
dc.date.issued2008-10-
dc.identifier.citationDirect binding and activation of protein kinase C isoforms by steroid hormones. 2008, 73 (9-10):885-8 Steroidsen
dc.identifier.issn0039-128X-
dc.identifier.pmid18329060-
dc.identifier.doi10.1016/j.steroids.2008.01.001-
dc.identifier.urihttp://hdl.handle.net/10147/136787-
dc.description.abstractThe non-genomic action of steroid hormones regulates a wide variety of cellular responses including regulation of ion transport, cell proliferation, migration, death and differentiation. In order to achieve such plethora of effects steroid hormones utilize nearly all known signal transduction pathways. One of the key signalling molecules regulating the non-genomic action of steroid hormones is protein kinase C (PKC). It is thought that rapid action of steroids hormones results from the activation of plasma membrane receptors; however, their molecular identity remains elusive. In recent years, an increasing number of studies have pointed at the selective binding and activation of specific PKC isoforms by steroid hormones. This has led to the hypothesis that PKC could act as a receptor as well as a transducer of the non-genomic effects of these hormones. In this review we summarize the current knowledge of the direct binding and activation of PKC by steroid hormones.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/18329060en
dc.subject.meshAldosterone-
dc.subject.meshAnimals-
dc.subject.meshBinding Sites-
dc.subject.meshEstradiol-
dc.subject.meshHumans-
dc.subject.meshModels, Biological-
dc.subject.meshMutation-
dc.subject.meshProtein Binding-
dc.subject.meshProtein Isoforms-
dc.subject.meshProtein Kinase C-
dc.subject.meshSteroids-
dc.titleDirect binding and activation of protein kinase C isoforms by steroid hormones.en
dc.typeArticleen
dc.contributor.departmentDepartment of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Smurfit Building, Beaumont Hospital PO Box 9063, Dublin 9, Ireland. AlzamoraR@dom.pitt.eduen
dc.identifier.journalSteroidsen
dc.description.provinceLeinster-

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