Sex and estrous cycle-dependent rapid protein kinase signaling actions of estrogen in distal colonic cells.

Hdl Handle:
http://hdl.handle.net/10147/136785
Title:
Sex and estrous cycle-dependent rapid protein kinase signaling actions of estrogen in distal colonic cells.
Authors:
O'Mahony, Fiona; Harvey, Brian J
Affiliation:
Department of Molecular Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland. fomahony@rcsi.ie
Citation:
Sex and estrous cycle-dependent rapid protein kinase signaling actions of estrogen in distal colonic cells. 2008, 73 (9-10):889-94 Steroids
Journal:
Steroids
Issue Date:
Oct-2008
URI:
http://hdl.handle.net/10147/136785
DOI:
10.1016/j.steroids.2008.01.021
PubMed ID:
18374379
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/18374379
Abstract:
Previous studies from our laboratory demonstrated that 17beta-estradiol (E2) rapidly inhibits Cl(-) secretion in rat and human distal colonic epithelium. The inhibition has been shown to occur via targeting of a basolateral K(+) channel identified as the KCNQ1 (KvLQT1) channel. E2 indirectly modulates the channel activity via a cascade of second messengers which are rapidly phosphorylated in response to E2. The anti-secretory mechanism may be the manner by which E2 induces fluid retention in the intestine during periods of high circulating plasma E2. Here we review the sex-dependent and estrous cycle regulation of this novel rapid response to E2. The inhibition of KCNQ1 channel activity and Cl(-) secretion will be of interest in the future in the investigation of the retentive effects of estrogen in female tissue and also in the study of secretory disorders and drugable targets of the intestine.
Item Type:
Article
Language:
en
MeSH:
Animals; Colon; Estradiol; Estrogens; Estrous Cycle; Female; Humans; Intestines; KCNQ1 Potassium Channel; Male; Models, Biological; Potassium Channels; Rats; Sex Factors; Signal Transduction
ISSN:
0039-128X

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Mahony, Fionaen
dc.contributor.authorHarvey, Brian Jen
dc.date.accessioned2011-07-25T08:37:43Z-
dc.date.available2011-07-25T08:37:43Z-
dc.date.issued2008-10-
dc.identifier.citationSex and estrous cycle-dependent rapid protein kinase signaling actions of estrogen in distal colonic cells. 2008, 73 (9-10):889-94 Steroidsen
dc.identifier.issn0039-128X-
dc.identifier.pmid18374379-
dc.identifier.doi10.1016/j.steroids.2008.01.021-
dc.identifier.urihttp://hdl.handle.net/10147/136785-
dc.description.abstractPrevious studies from our laboratory demonstrated that 17beta-estradiol (E2) rapidly inhibits Cl(-) secretion in rat and human distal colonic epithelium. The inhibition has been shown to occur via targeting of a basolateral K(+) channel identified as the KCNQ1 (KvLQT1) channel. E2 indirectly modulates the channel activity via a cascade of second messengers which are rapidly phosphorylated in response to E2. The anti-secretory mechanism may be the manner by which E2 induces fluid retention in the intestine during periods of high circulating plasma E2. Here we review the sex-dependent and estrous cycle regulation of this novel rapid response to E2. The inhibition of KCNQ1 channel activity and Cl(-) secretion will be of interest in the future in the investigation of the retentive effects of estrogen in female tissue and also in the study of secretory disorders and drugable targets of the intestine.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/18374379en
dc.subject.meshAnimals-
dc.subject.meshColon-
dc.subject.meshEstradiol-
dc.subject.meshEstrogens-
dc.subject.meshEstrous Cycle-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIntestines-
dc.subject.meshKCNQ1 Potassium Channel-
dc.subject.meshMale-
dc.subject.meshModels, Biological-
dc.subject.meshPotassium Channels-
dc.subject.meshRats-
dc.subject.meshSex Factors-
dc.subject.meshSignal Transduction-
dc.titleSex and estrous cycle-dependent rapid protein kinase signaling actions of estrogen in distal colonic cells.en
dc.typeArticleen
dc.contributor.departmentDepartment of Molecular Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland. fomahony@rcsi.ieen
dc.identifier.journalSteroidsen
dc.description.provinceLeinster-

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