Photoprotective behaviour and sunscreen use: impact on vitamin D levels in cutaneous lupus erythematosus.

Hdl Handle:
http://hdl.handle.net/10147/136776
Title:
Photoprotective behaviour and sunscreen use: impact on vitamin D levels in cutaneous lupus erythematosus.
Authors:
Cusack, Caitriona; Danby, Claire; Fallon, Jason C; Ho, Wen Lyn; Murray, Barbara; Brady, Jennifer; O'Kelly, Patrick; Ambrose, Nicola; Kearns, Grainne; Murphy, Gillian M
Affiliation:
Department of Dermatology, Beaumont Hospital, Dublin, Ireland.
Citation:
Photoprotective behaviour and sunscreen use: impact on vitamin D levels in cutaneous lupus erythematosus. 2008, 24 (5):260-7 Photodermatol Photoimmunol Photomed
Journal:
Photodermatology, photoimmunology & photomedicine
Issue Date:
Oct-2008
URI:
http://hdl.handle.net/10147/136776
DOI:
10.1111/j.1600-0781.2008.00373.x
PubMed ID:
18811868
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/18811868
Abstract:
Sun exposure of the skin, independent of dietary sources, may provide sufficient vitamin D in healthy individuals. A recent study of patients with cutaneous lupus erythematosus concluded that over 70% of them restrict their sun exposure.; We recruited 52 patients with biopsy-proven cutaneous lupus erythematosus to establish whether they are deficient in 25-hydroxyvitamin D [25(OH)D]. We measured their serum 25(OH)D levels during summer months, investigated the effects of several variables on 25(OH)D levels and assessed the role of vitamin D supplementation.; An overall mean 25(OH)D level of 63.03 (+/-23.3) nmol/l was obtained. Significantly low values (<25 nmol/l) were recorded in two (3.8%) patients and concentrations below 75 nmol/l were found in 34 (65.4%) patients. 25(OH)D levels were significantly lower among sun avoiders and daily sunscreen users, while significantly higher values were found among those who took cholecalciferol (vitamin D3) supplements. Low values were recorded among those with renal disease despite supplementation with vitamin D3 in some cases.; We suggest that patients with cutaneous lupus erythematous have suboptimal 25(OH)D levels, which are significantly raised by the addition of at least 400 IU/day of cholecalciferol. We recommend supplementation with an active vitamin D analogue in collaboration with a consultant nephrologist, for the subgroup of patients with renal disease.
Item Type:
Article
Language:
en
MeSH:
Adult; Aged; Calcitriol; Cholecalciferol; Female; Humans; Lupus Erythematosus, Cutaneous; Male; Middle Aged; Seasons; Skin; Sunlight; Sunscreening Agents
ISSN:
1600-0781

Full metadata record

DC FieldValue Language
dc.contributor.authorCusack, Caitrionaen
dc.contributor.authorDanby, Claireen
dc.contributor.authorFallon, Jason Cen
dc.contributor.authorHo, Wen Lynen
dc.contributor.authorMurray, Barbaraen
dc.contributor.authorBrady, Jenniferen
dc.contributor.authorO'Kelly, Patricken
dc.contributor.authorAmbrose, Nicolaen
dc.contributor.authorKearns, Grainneen
dc.contributor.authorMurphy, Gillian Men
dc.date.accessioned2011-07-25T08:33:39Z-
dc.date.available2011-07-25T08:33:39Z-
dc.date.issued2008-10-
dc.identifier.citationPhotoprotective behaviour and sunscreen use: impact on vitamin D levels in cutaneous lupus erythematosus. 2008, 24 (5):260-7 Photodermatol Photoimmunol Photomeden
dc.identifier.issn1600-0781-
dc.identifier.pmid18811868-
dc.identifier.doi10.1111/j.1600-0781.2008.00373.x-
dc.identifier.urihttp://hdl.handle.net/10147/136776-
dc.description.abstractSun exposure of the skin, independent of dietary sources, may provide sufficient vitamin D in healthy individuals. A recent study of patients with cutaneous lupus erythematosus concluded that over 70% of them restrict their sun exposure.-
dc.description.abstractWe recruited 52 patients with biopsy-proven cutaneous lupus erythematosus to establish whether they are deficient in 25-hydroxyvitamin D [25(OH)D]. We measured their serum 25(OH)D levels during summer months, investigated the effects of several variables on 25(OH)D levels and assessed the role of vitamin D supplementation.-
dc.description.abstractAn overall mean 25(OH)D level of 63.03 (+/-23.3) nmol/l was obtained. Significantly low values (<25 nmol/l) were recorded in two (3.8%) patients and concentrations below 75 nmol/l were found in 34 (65.4%) patients. 25(OH)D levels were significantly lower among sun avoiders and daily sunscreen users, while significantly higher values were found among those who took cholecalciferol (vitamin D3) supplements. Low values were recorded among those with renal disease despite supplementation with vitamin D3 in some cases.-
dc.description.abstractWe suggest that patients with cutaneous lupus erythematous have suboptimal 25(OH)D levels, which are significantly raised by the addition of at least 400 IU/day of cholecalciferol. We recommend supplementation with an active vitamin D analogue in collaboration with a consultant nephrologist, for the subgroup of patients with renal disease.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/18811868en
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshCalcitriol-
dc.subject.meshCholecalciferol-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLupus Erythematosus, Cutaneous-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshSeasons-
dc.subject.meshSkin-
dc.subject.meshSunlight-
dc.subject.meshSunscreening Agents-
dc.titlePhotoprotective behaviour and sunscreen use: impact on vitamin D levels in cutaneous lupus erythematosus.en
dc.typeArticleen
dc.contributor.departmentDepartment of Dermatology, Beaumont Hospital, Dublin, Ireland.en
dc.identifier.journalPhotodermatology, photoimmunology & photomedicineen
dc.description.provinceLeinster-

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