Endoscopic tissue diagnosis of cholangiocarcinoma.

Hdl Handle:
http://hdl.handle.net/10147/136772
Title:
Endoscopic tissue diagnosis of cholangiocarcinoma.
Authors:
Harewood, Gavin C
Affiliation:
Division of Gastroenterology and Hepatology, Beaumont Hospital, Dublin, Ireland. harewood.gavin@gmail.com
Citation:
Endoscopic tissue diagnosis of cholangiocarcinoma. 2008, 24 (5):627-30 Curr. Opin. Gastroenterol.
Journal:
Current opinion in gastroenterology
Issue Date:
Sep-2008
URI:
http://hdl.handle.net/10147/136772
DOI:
10.1097/MOG.0b013e32830bf7e1
PubMed ID:
19122506
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/19122506
Abstract:
The extremely poor outcome in patients with cholangiocarcinoma, in large part, reflects the late presentation of these tumors and the challenging nature of establishing a tissue diagnosis. Establishing a diagnosis of cholangiocarcinoma requires obtaining evidence of malignancy from sampling of the epithelium of the biliary tract, which has proven to be challenging. Although endoscopic ultrasound-guided fine needle aspiration performs slightly better than endoscopic retrograde cholangiopancreatography in diagnosing cholangiocarcinoma, both endoscopic approaches demonstrate disappointing performance characteristics.; The limitations of cytologic analysis have recently led to the evaluation of new technologies such as digital image analysis and fluorescence in-situ hybridization to enhance diagnostic sensitivity. Both of these approaches carry the ability to identify malignant cells in samples of limited cellularity and thereby provide enhanced diagnostic sensitivity.; Overall, recognizing the limited sensitivity of diagnostic approaches for tissue diagnosis of cholangiocarcinoma, it would appear prudent to pursue further tissue sampling when there is a strong clinical suspicion of malignancy despite a prior negative/nondiagnostic result.
Item Type:
Article
Language:
en
MeSH:
Bile Duct Neoplasms; Biopsy, Fine-Needle; Cholangiocarcinoma; Cholangiography; Cholangiopancreatography, Endoscopic Retrograde; Early Detection of Cancer; Endosonography; Humans; Image Interpretation, Computer-Assisted; Neoplasm Invasiveness; Neoplasm Staging; Risk Assessment; Sensitivity and Specificity
ISSN:
1531-7056

Full metadata record

DC FieldValue Language
dc.contributor.authorHarewood, Gavin Cen
dc.date.accessioned2011-07-25T08:30:58Z-
dc.date.available2011-07-25T08:30:58Z-
dc.date.issued2008-09-
dc.identifier.citationEndoscopic tissue diagnosis of cholangiocarcinoma. 2008, 24 (5):627-30 Curr. Opin. Gastroenterol.en
dc.identifier.issn1531-7056-
dc.identifier.pmid19122506-
dc.identifier.doi10.1097/MOG.0b013e32830bf7e1-
dc.identifier.urihttp://hdl.handle.net/10147/136772-
dc.description.abstractThe extremely poor outcome in patients with cholangiocarcinoma, in large part, reflects the late presentation of these tumors and the challenging nature of establishing a tissue diagnosis. Establishing a diagnosis of cholangiocarcinoma requires obtaining evidence of malignancy from sampling of the epithelium of the biliary tract, which has proven to be challenging. Although endoscopic ultrasound-guided fine needle aspiration performs slightly better than endoscopic retrograde cholangiopancreatography in diagnosing cholangiocarcinoma, both endoscopic approaches demonstrate disappointing performance characteristics.-
dc.description.abstractThe limitations of cytologic analysis have recently led to the evaluation of new technologies such as digital image analysis and fluorescence in-situ hybridization to enhance diagnostic sensitivity. Both of these approaches carry the ability to identify malignant cells in samples of limited cellularity and thereby provide enhanced diagnostic sensitivity.-
dc.description.abstractOverall, recognizing the limited sensitivity of diagnostic approaches for tissue diagnosis of cholangiocarcinoma, it would appear prudent to pursue further tissue sampling when there is a strong clinical suspicion of malignancy despite a prior negative/nondiagnostic result.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/19122506en
dc.subject.meshBile Duct Neoplasms-
dc.subject.meshBiopsy, Fine-Needle-
dc.subject.meshCholangiocarcinoma-
dc.subject.meshCholangiography-
dc.subject.meshCholangiopancreatography, Endoscopic Retrograde-
dc.subject.meshEarly Detection of Cancer-
dc.subject.meshEndosonography-
dc.subject.meshHumans-
dc.subject.meshImage Interpretation, Computer-Assisted-
dc.subject.meshNeoplasm Invasiveness-
dc.subject.meshNeoplasm Staging-
dc.subject.meshRisk Assessment-
dc.subject.meshSensitivity and Specificity-
dc.titleEndoscopic tissue diagnosis of cholangiocarcinoma.en
dc.typeArticleen
dc.contributor.departmentDivision of Gastroenterology and Hepatology, Beaumont Hospital, Dublin, Ireland. harewood.gavin@gmail.comen
dc.identifier.journalCurrent opinion in gastroenterologyen
dc.description.provinceLeinster-

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