Toll-like receptors as therapeutic targets in cystic fibrosis.

Hdl Handle:
http://hdl.handle.net/10147/136766
Title:
Toll-like receptors as therapeutic targets in cystic fibrosis.
Authors:
Greene, Catherine M; Branagan, Peter; McElvaney, Noel G
Affiliation:
Beaumont Hospital, Education and Research Centre, Respiratory Research Division, Royal College of Surgeons in Ireland, 9 Dublin, Ireland. cmgreene@rcsi.ie
Citation:
Toll-like receptors as therapeutic targets in cystic fibrosis. 2008, 12 (12):1481-95 Expert Opin. Ther. Targets
Journal:
Expert opinion on therapeutic targets
Issue Date:
Dec-2008
URI:
http://hdl.handle.net/10147/136766
DOI:
10.1517/14728220802515293
PubMed ID:
19007318
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/19007318
Abstract:
Background: Toll-like receptors (TLRs) are pattern recognition receptors that act as a first-line of defence in the innate immune response by recognising and responding to conserved molecular patterns in microbial factors and endogenous danger signals. Cystic fibrosis (CF)-affected airways represent a milieu potentially rich in TLR agonists and the chronic inflammatory phenotype evident in CF airway epithelial cells is probably due in large part to activation of TLRs. Objective/methods: To examine the prospects of developing novel therapies for CF by targeting TLRs. We outline the expression and function of TLRs and explore the therapeutic potential of naturally-occurring and synthetic TLR inhibitors for CF. Results/conclusion: Modulation of TLRs has therapeutic potential for the inflammatory lung manifestations of CF.
Item Type:
Article
Language:
en
MeSH:
Anti-Inflammatory Agents, Non-Steroidal; Cystic Fibrosis; Drug Design; Gene Expression Regulation; Humans; Toll-Like Receptors
ISSN:
1744-7631

Full metadata record

DC FieldValue Language
dc.contributor.authorGreene, Catherine Men
dc.contributor.authorBranagan, Peteren
dc.contributor.authorMcElvaney, Noel Gen
dc.date.accessioned2011-07-25T08:32:38Z-
dc.date.available2011-07-25T08:32:38Z-
dc.date.issued2008-12-
dc.identifier.citationToll-like receptors as therapeutic targets in cystic fibrosis. 2008, 12 (12):1481-95 Expert Opin. Ther. Targetsen
dc.identifier.issn1744-7631-
dc.identifier.pmid19007318-
dc.identifier.doi10.1517/14728220802515293-
dc.identifier.urihttp://hdl.handle.net/10147/136766-
dc.description.abstractBackground: Toll-like receptors (TLRs) are pattern recognition receptors that act as a first-line of defence in the innate immune response by recognising and responding to conserved molecular patterns in microbial factors and endogenous danger signals. Cystic fibrosis (CF)-affected airways represent a milieu potentially rich in TLR agonists and the chronic inflammatory phenotype evident in CF airway epithelial cells is probably due in large part to activation of TLRs. Objective/methods: To examine the prospects of developing novel therapies for CF by targeting TLRs. We outline the expression and function of TLRs and explore the therapeutic potential of naturally-occurring and synthetic TLR inhibitors for CF. Results/conclusion: Modulation of TLRs has therapeutic potential for the inflammatory lung manifestations of CF.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/19007318en
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal-
dc.subject.meshCystic Fibrosis-
dc.subject.meshDrug Design-
dc.subject.meshGene Expression Regulation-
dc.subject.meshHumans-
dc.subject.meshToll-Like Receptors-
dc.titleToll-like receptors as therapeutic targets in cystic fibrosis.en
dc.typeArticleen
dc.contributor.departmentBeaumont Hospital, Education and Research Centre, Respiratory Research Division, Royal College of Surgeons in Ireland, 9 Dublin, Ireland. cmgreene@rcsi.ieen
dc.identifier.journalExpert opinion on therapeutic targetsen
dc.description.provinceLeinster-

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