The effect of preoperative renal dysfunction with or without dialysis on early postoperative outcome following cardiac surgery.

Hdl Handle:
http://hdl.handle.net/10147/136402
Title:
The effect of preoperative renal dysfunction with or without dialysis on early postoperative outcome following cardiac surgery.
Authors:
Al-Sarraf, Nael; Thalib, Lukman; Hughes, Anne; Houlihan, Maighread; Tolan, Michael; Young, Vincent; McGovern, Eillish
Affiliation:
Department of Cardiothoracic Surgery, St. James's Hospital, Dublin 8, Ireland. trinityq8@hotmail.com
Citation:
The effect of preoperative renal dysfunction with or without dialysis on early postoperative outcome following cardiac surgery. 2011, 9 (2):183-7 Int J Surg
Journal:
International journal of surgery (London, England)
Issue Date:
2011
URI:
http://hdl.handle.net/10147/136402
DOI:
10.1016/j.ijsu.2010.11.006
PubMed ID:
21087685
Abstract:
Although previous studies have shown increased mortality in renal dysfunction patients undergoing cardiac surgery, there is lack of data on the pattern of postoperative complications that occur in such patients and their distribution among dialysis and non-dialysis dependent renal dysfunction.; This is a retrospective review of prospectively collected data over 8 year period of cardiac surgery patients. Our cohort consisted of 3598 consecutive patients divided into: normal kidneys (n = 3276, 91%), renal dysfunction (n = 277, 8%) and dialysis (n = 45, 1%). Postoperative complications and mortality were analysed. Multivariate analysis was conducted to adjust for the potential confounders in the association between renal dysfunction and postoperative complications.; Univariate analysis showed increased risk of the following complications among renal dysfunction and dialysis patients: low cardiac output, arrhythmias, reoperation, prolonged ventilation, readmission to intensive care, blood transfusion and prolonged hospital stay. Mortality rate was highest in dialysis patients compared to renal dysfunction and normal kidney patients (11% vs. 7% vs. 3%, respectively p-value <0.001). Multivariate analysis showed that renal dysfunction with or without dialysis is an independent predictor of postoperative low cardiac output, blood transfusion, prolonged ventilation, and mortality. The odd ratios were higher for dialysis than non-dialysis dependent patients. This effect persisted after adjusting for potential confounders such as age and gender.; The presence of renal dysfunction preoperatively increases the rate of postoperative complications and mortality following cardiac surgery. Prior knowledge of these complications can help in developing preventative strategies to reduce the associated risk.
Item Type:
Article
Language:
en
MeSH:
Adult; Aged; Aged, 80 and over; Cardiopulmonary Bypass; Cohort Studies; Female; Humans; Male; Middle Aged; Postoperative Complications; Preoperative Period; Renal Dialysis; Renal Insufficiency; Retrospective Studies; Risk Factors
ISSN:
1743-9159

Full metadata record

DC FieldValue Language
dc.contributor.authorAl-Sarraf, Naelen
dc.contributor.authorThalib, Lukmanen
dc.contributor.authorHughes, Anneen
dc.contributor.authorHoulihan, Maighreaden
dc.contributor.authorTolan, Michaelen
dc.contributor.authorYoung, Vincenten
dc.contributor.authorMcGovern, Eillishen
dc.date.accessioned2011-07-20T11:32:37Z-
dc.date.available2011-07-20T11:32:37Z-
dc.date.issued2011-
dc.identifier.citationThe effect of preoperative renal dysfunction with or without dialysis on early postoperative outcome following cardiac surgery. 2011, 9 (2):183-7 Int J Surgen
dc.identifier.issn1743-9159-
dc.identifier.pmid21087685-
dc.identifier.doi10.1016/j.ijsu.2010.11.006-
dc.identifier.urihttp://hdl.handle.net/10147/136402-
dc.description.abstractAlthough previous studies have shown increased mortality in renal dysfunction patients undergoing cardiac surgery, there is lack of data on the pattern of postoperative complications that occur in such patients and their distribution among dialysis and non-dialysis dependent renal dysfunction.-
dc.description.abstractThis is a retrospective review of prospectively collected data over 8 year period of cardiac surgery patients. Our cohort consisted of 3598 consecutive patients divided into: normal kidneys (n = 3276, 91%), renal dysfunction (n = 277, 8%) and dialysis (n = 45, 1%). Postoperative complications and mortality were analysed. Multivariate analysis was conducted to adjust for the potential confounders in the association between renal dysfunction and postoperative complications.-
dc.description.abstractUnivariate analysis showed increased risk of the following complications among renal dysfunction and dialysis patients: low cardiac output, arrhythmias, reoperation, prolonged ventilation, readmission to intensive care, blood transfusion and prolonged hospital stay. Mortality rate was highest in dialysis patients compared to renal dysfunction and normal kidney patients (11% vs. 7% vs. 3%, respectively p-value <0.001). Multivariate analysis showed that renal dysfunction with or without dialysis is an independent predictor of postoperative low cardiac output, blood transfusion, prolonged ventilation, and mortality. The odd ratios were higher for dialysis than non-dialysis dependent patients. This effect persisted after adjusting for potential confounders such as age and gender.-
dc.description.abstractThe presence of renal dysfunction preoperatively increases the rate of postoperative complications and mortality following cardiac surgery. Prior knowledge of these complications can help in developing preventative strategies to reduce the associated risk.-
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshCardiopulmonary Bypass-
dc.subject.meshCohort Studies-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshPostoperative Complications-
dc.subject.meshPreoperative Period-
dc.subject.meshRenal Dialysis-
dc.subject.meshRenal Insufficiency-
dc.subject.meshRetrospective Studies-
dc.subject.meshRisk Factors-
dc.titleThe effect of preoperative renal dysfunction with or without dialysis on early postoperative outcome following cardiac surgery.en
dc.typeArticleen
dc.contributor.departmentDepartment of Cardiothoracic Surgery, St. James's Hospital, Dublin 8, Ireland. trinityq8@hotmail.comen
dc.identifier.journalInternational journal of surgery (London, England)en
dc.description.provinceLeinster-

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