Somnolence in adult craniopharyngioma patients is a common, heterogeneous condition that is potentially treatable.

Hdl Handle:
http://hdl.handle.net/10147/136375
Title:
Somnolence in adult craniopharyngioma patients is a common, heterogeneous condition that is potentially treatable.
Authors:
Crowley, R K; Woods, C; Fleming, M; Rogers, B; Behan, L A; O'Sullivan, E P; Kane, T; Agha, A; Smith, D; Costello, R W; Thompson, C J
Affiliation:
Department of Academic Endocrinology, Beaumont Hospital, Dublin 9, Ireland.
Citation:
Somnolence in adult craniopharyngioma patients is a common, heterogeneous condition that is potentially treatable. 2011, 74 (6):750-5 Clin. Endocrinol. (Oxf)
Journal:
Clinical endocrinology
Issue Date:
Jun-2011
URI:
http://hdl.handle.net/10147/136375
DOI:
10.1111/j.1365-2265.2011.03993.x
PubMed ID:
21521265
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/21521265
Abstract:
Somnolence and obesity are prevalent in craniopharyngioma patients. We hypothesized that somnolence was because of obstructive sleep apnoea in craniopharyngioma patients.; We assessed prevalence of somnolence and sleep apnoea in 28 craniopharyngioma and 23 obese controls attending a tertiary referral centre, by means of the Epworth Sleepiness Score (ESS) and polysomnography. All subjects with sleep apnoea were offered continuous positive airway pressure therapy (CPAP) or modafinil. All craniopharyngioma patients, with unexplained somnolence, were offered modafinil.; Somnolence was reported by 20/28 (71·5%) craniopharyngioma patients and 4/23 (17%) obese subjects (P < 0·001). Median ESS was 7·5 (IQR 6, 10·7) in craniopharyngioma patients and 4·0 (4,8) in controls, P < 0·01. Eleven somnolent craniopharyngioma patients had obstructive sleep apnoea, in whom treatment led to a reduction in ESS by 6·4 ± 1·4, P = 0·01. Among the remaining nine patients, five were offered modafinil therapy, of whom four had benefit, three were not compliant with hormone replacement, and one died before intervention. There was no difference in the prevalence of obstructive sleep apnoea between craniopharyngioma (n = 13, 46%) and obese subjects (n = 14, 61%, P = 0·4). Body mass index (BMI) does not correlate with apnoea hypopnoea index [apnoea - hypopnoea index (AHI), r = 0·25, P = 0·08], which suggests that obesity alone does not explain the prevalence of sleep apnoea in craniopharyngioma patients.; Somnolence is common in craniopharyngioma patients and in the majority is because of obstructive sleep apnoea. An additional group of somnolent craniopharyngioma patients benefits from modafinil.
Item Type:
Article
Language:
en
ISSN:
1365-2265

Full metadata record

DC FieldValue Language
dc.contributor.authorCrowley, R Ken
dc.contributor.authorWoods, Cen
dc.contributor.authorFleming, Men
dc.contributor.authorRogers, Ben
dc.contributor.authorBehan, L Aen
dc.contributor.authorO'Sullivan, E Pen
dc.contributor.authorKane, Ten
dc.contributor.authorAgha, Aen
dc.contributor.authorSmith, Den
dc.contributor.authorCostello, R Wen
dc.contributor.authorThompson, C Jen
dc.date.accessioned2011-07-20T10:07:23Z-
dc.date.available2011-07-20T10:07:23Z-
dc.date.issued2011-06-
dc.identifier.citationSomnolence in adult craniopharyngioma patients is a common, heterogeneous condition that is potentially treatable. 2011, 74 (6):750-5 Clin. Endocrinol. (Oxf)en
dc.identifier.issn1365-2265-
dc.identifier.pmid21521265-
dc.identifier.doi10.1111/j.1365-2265.2011.03993.x-
dc.identifier.urihttp://hdl.handle.net/10147/136375-
dc.description.abstractSomnolence and obesity are prevalent in craniopharyngioma patients. We hypothesized that somnolence was because of obstructive sleep apnoea in craniopharyngioma patients.-
dc.description.abstractWe assessed prevalence of somnolence and sleep apnoea in 28 craniopharyngioma and 23 obese controls attending a tertiary referral centre, by means of the Epworth Sleepiness Score (ESS) and polysomnography. All subjects with sleep apnoea were offered continuous positive airway pressure therapy (CPAP) or modafinil. All craniopharyngioma patients, with unexplained somnolence, were offered modafinil.-
dc.description.abstractSomnolence was reported by 20/28 (71·5%) craniopharyngioma patients and 4/23 (17%) obese subjects (P < 0·001). Median ESS was 7·5 (IQR 6, 10·7) in craniopharyngioma patients and 4·0 (4,8) in controls, P < 0·01. Eleven somnolent craniopharyngioma patients had obstructive sleep apnoea, in whom treatment led to a reduction in ESS by 6·4 ± 1·4, P = 0·01. Among the remaining nine patients, five were offered modafinil therapy, of whom four had benefit, three were not compliant with hormone replacement, and one died before intervention. There was no difference in the prevalence of obstructive sleep apnoea between craniopharyngioma (n = 13, 46%) and obese subjects (n = 14, 61%, P = 0·4). Body mass index (BMI) does not correlate with apnoea hypopnoea index [apnoea - hypopnoea index (AHI), r = 0·25, P = 0·08], which suggests that obesity alone does not explain the prevalence of sleep apnoea in craniopharyngioma patients.-
dc.description.abstractSomnolence is common in craniopharyngioma patients and in the majority is because of obstructive sleep apnoea. An additional group of somnolent craniopharyngioma patients benefits from modafinil.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21521265en
dc.titleSomnolence in adult craniopharyngioma patients is a common, heterogeneous condition that is potentially treatable.en
dc.typeArticleen
dc.contributor.departmentDepartment of Academic Endocrinology, Beaumont Hospital, Dublin 9, Ireland.en
dc.identifier.journalClinical endocrinologyen
dc.description.provinceLeinster-

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